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Публикации Черешнева В.А.
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Общее количество найденных документов : 37
Показаны документы с 1 по 20
 1-20    21-37 
1.
Инвентарный номер: нет.
   
   E 27

   
    Effect of polyoxidonium on phagocytic cell functions. Experimental and Clinical estimation of potential inclusion of polyoxidonium in complex therapy in penetrating eye injury / V. A. Chereshnev, Y. I. Shilov , M. V. Chereshneva, L. A. Platova, O. N. Badanina, S. V. Osotov, T. B. Ponomareva // Russian Journal of Immunology. - 2000. - Vol. 5, № 1. - P. 39-52 : fig. - Bibliogr. : p. 51-52 (23 ref)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
POLYOXIDONIUM -- PENETRATING EYE INJURY

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2.
Инвентарный номер: нет.
   
   S 54

    Shilov, Y. I.
    Influence of Blockade of β-Adrenoreceptors and Acute Stress on Antibody Formation, Delayed Type of Hypersensitivity, Phagocytic Cell Activity in Local Immune Response / Y. I. Shilov , S. V. Gein , V. A. Chereshnev // Russian Journal of Immunology. - 2001. - Vol. 6, № 3. - P. 301-308 : fig., tabl. - Bibliogr. : p. 308 (17 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
β-ADRENORECEPTORS -- ANTIBODY FORMATION -- HYPERSENSITIVITY -- PHAGOCYTIC CELL ACTIVITY

\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Российский иммунологический журнал\\2001. - Vol. 6, № 3. - P. 301-308.PDF
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3.
Инвентарный номер: нет.
   
   I-60

   
    Influence of myelopid, myelopeptides MP-5 and MP-6 on lymphocyte proliferative activity / T. V. Gavrilova, S. V. Gein, T. A. Pogudina, V. A. Chereshnev // Doklady Akademii Nauk . - 2004. - Vol.398, №4. - P560-562
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
CELL CULTURE -- COMPOSITION EFFECTS -- LYMPHOCYTES
Аннотация: The effect on activity of peripheral blood lymphocytes upon blast-transformation reaction induced by phytohemagglutinin (PGA) in different concentrations was investigated. For the first time the different-directed activity of MP-6 tetrapeptide in respect to stimulated PGA and non-stimulated peripheral blood lymphocytes is shown. Dependence of MP-6 effects on its own concentration as well as on the mitogen concentration in the cell culture is demonstrated. Myelopid and MP-5 didn't affect the lymphocyte functional activity

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4.
Инвентарный номер: нет.
   
   M 45

   
    Mechanism underlying the effect of myelopeptides on lymphocyte proliferation in vitro [Electronic resource] / T. V. Gavrilova, S. V. Gein, T. A. Pogudina, V. A. Chereshnev // Bulletin of experimental biology and medicine. - 2005. - Vol. 140, № 1. - P74-76. - Bibliogr. : p. 76 (7 ref.)
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
LYMPHOCYTE BLAST TRANSFORMATION -- MONOCYTES -- MYELOPEPTIDES
Аннотация: We studied the role of monocytes in the effect of myelopid and myelopeptides MP-1, MP-3, MP-5, and MP-6 on functional activity of peripheral blood lymphocytes in the reaction of blast transformation. Myelopeptides MP-1, MP-3, and MP-6 suppressed blast transformation of lymphocytes. The effect depended on the presence of monocytes in a cell culture

\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2005, v.140, N 1, p. 74.pdf
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5.
Инвентарный номер: нет.
   
   R 74

   
    Role of functional activity of phagocytic mononuclear system in the formation of autoprostheses for angioplasty [Electronic resource] / V. A. Chereshnev, N. V. Tyumentseva, B. G. Yushkov, I. G. Danilova, V. V, Khodakov, D. I. Krokhin, S. Yu. Medvedeva // Bulletin of experimental biology and medicine. - 2005. - Vol. 140, № 2. - P217-218. - Bibliogr. : p. 218 (9 ref.)
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
CARRAGEENAN -- PHAGOCYTIC MONONUCLEAR SYSTEM -- TAMERITE
Аннотация: The possibility of formation of connective-tissue vascular prostheses on subcutaneously implanted polychlorovynil base was demonstrated in experiments on rats. Suppression of the function of phagocytic cell with carrageenan decelerates, while its stimulation with tamerit accelerates the formation of connective-tissue autoprostheses.

\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2005, v.140, N 2, p. 217.pdf
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6.
Инвентарный номер: нет.
   
   A 41

   
    Alpha-fetoprotein immunotherapy as a stage of combined treatment of cancer patients / V. A. Chereshnev, S. Yu. Rodionov, N. V. Vasilyev, O. A. Orlov, V. A. Cherkassov // Voprosy Onkologii . - 2005. - Vol.51, №1. - P86-92
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ALPHA FETOPROTEIN -- ANTIBODY -- APOPTOSIS
Аннотация: The paper discusses the preliminary findings on alpha-feto-protein (AFP) treatment of 58 patients with stage III-IV malignancies of different localizations.influence on neoplastic processes was registered in poorly differentiated cell tumors, nor were any immunological mechanisms of antitumor action triggered on. However, in moderately- and well-differentiated cell tumors, several foci of acute immune inflammation were induced. It is suggested that AFP is responsible for tumor cell apoptosis by freeing antigenic determinants from shielding antibodies via elimination of «immunological enhancement» of tumor growth.

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7.
Инвентарный номер: нет.
   
   T 44

   
    The role of monocytes in the effects of β-endorphin and selective agonists of μ-and δ-opiate receptors on the proliferative activity of peripheral blood lymphocytes / S. V. Gein, T. A. Baeva, O. N. Gein, V. A. Chereshnev // Human Physiology. - 2006. - Vol. 32, № 3. - P346-350
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
MONOCYTES -- BETA ENDORPHIN -- BLOOD LYMPHOCYTES
Аннотация: The effects of β-endorphin under the conditions of naloxone hydrochloride blockade of opiate receptors, as well as the effects of the selective agonists of μ-and δ-receptors DAGO and DADLE and the effects of melanocyte-potentiating factor (MPF), on the in vitro proliferative response of lymphocytes were studied. The dose-effect dependence indicated stimulating effects of β-endorphin, DAGO, and DADLE on the proliferative response in the presence of phytohemagglutinin (PHA). The tetrapeptide MPF, which is the C-terminal sequence of β-endorphin, had almost no effect on the proliferative activity of lymphocytes. β-Endorphin, naloxone, and the μ-and δ-receptor selective agonists enhanced the proliferative response of lymphocytes in an unfractionated cell culture, whereas β-endorphin, naloxone, and DAGO suppressed the proliferative activity of lymphocytes in the mononuclear fraction purified of monocytes. In both cases, the naloxone blockade of opiate receptors enhanced rather than eliminated the β-endorphin e

\\\\expert2\\nbo\\Human Physiology\\2006. V. 32, N 3. P. 346-350.pdf
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8.
Инвентарный номер: нет.
   
   T 44

   
    The use of profetal for correction of the stress-and trauma-induced changes in the immune response against a xenogeneic antigen in rats with a penetrating wound of the eye / V. A. Chereshnev, M. V. Chereshneva, R. R. Faizrakhmanov, T. V. Gavrilova // Doklady Biological Sciences. - 2007. - Vol. 417, № 1. - С. 420-422
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ALPHA FETOPROTEIN -- PRODUCING CELL -- ERYTHROCYTE

\\\\expert2\\NBO\\Doklady Biological Sciences\\2007. V. 417, N 1.P. 420.pdf
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9.
Инвентарный номер: нет.
   
   I-57

   
    In vitro immunomodulating properties of biosurfactant glicolipid complex in the rhodococcus rubber. The role of monocyte and cell adhesion / S. V. Gein, M. S. Kuyukina, I. B. Ivshina [et al.] // Environmental pollution, adaptation, immunity : abstracts VII International Conference. - Perm, 2008. - P147
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
IMMUNOMODULATING PROPERTIES -- GLICOLIPID COMPLEX -- MONOCYTES

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10.
Инвентарный номер: нет.
   
   В 58

   
    Влияние «Профеталя» на морфологические изменения в селезенке при экспериментальном проникающем ранении глаза / В. А. Черешнев, Ю. И. Шилов, М. В. Черешнева [и др.] // Морфологические ведомости. - 2009. - Т. 1, № 1-2. - С. 68-70. - Библиогр.: с. 70 (15 назв.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ПРОФЕТАЛЬ -- ПРОНИКАЮЩЕЕ РАНЕНИЕ ГЛАЗА -- СЕЛЕЗЕНКА
Аннотация: The study of the effect of immune modulator profetal (alpha% fetoprotein as an active substance) on morphological changes in spleen under the experimental eye penetrating injury has been made in 46 Wistar male rats. Histological and morphometric methods were used in this work. It was determined that the use of profetal led to an increase in size of spleen B cell%depended areas and number of macrophages

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11.
Инвентарный номер: нет.
   

   
    Влияние "профеталя"® на морфологические изменения в селезенке при экспериментальном проникающем ранении глаза / В. А. Черешнев, Ю. И. Шилов, М. В. Черешнева, Т. В. Гаврилова // Морфологические ведомости. - 2009. - Т. 1, № 1/2. - С. 68-70
Кл.слова (ненормированные):
ПРОФЕТАЛЬ -- МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ -- СЕЛЕЗЕНКА
Аннотация: The study of the effect of immune modulator profetal (alpha% fetoprotein as an active substance) on morphological changes in spleen under the experimental eye penetrating injury has been made in 46 Wistar male rats. Histological and morphometric methods were used in this work. It was determined that the use of profetal led to an increase in size of spleen B cell%depended areas and number of macrophages

\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Морфологические ведомости\\2009. Т.1, №12. С. 68-70.pdf
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12.
Инвентарный номер: нет.
   

   
    Modulation of Cytokine secretion and oxidative metabolism of innate immune effectors by Rhodococcus Biosurfactant / V. A. Chereshnev, S. V. Gein, T. A. Baeva [et al.] // Bulletin of experimental biology and medicine. - 2010. - Vol. 149, № 6. - P734-738
Кл.слова (ненормированные):
RHODOCOCCUS RUBBEr -- GLYCOLIPID BIOSURFACTANT -- INTERLEUKIN-10
Аннотация: The glycolipid biosurfactant complex from Rhodococcus ruber IEGM 231 had a stimulatory effect on the production of IL-12, IL-18, and reactive oxygen species by cells of the innate immunity. This effect depended on the composition of cell cultures and presence of LPS. It was primarily observed in non-stimulated cultures. The glycolipid biosurfactant complex had little effect on IL-10 secretion by monocytes and mononuclear cells

\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2010, v.149, N 6, p. 734-738.pdf
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13.
Инвентарный номер: нет.
   
   A 10

   
    A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections. / G. Bocharov, R. Züst, L. Cervantes-Barragan [et al.] // PLOS pathogens. - 2010. - Vol. 6, № 7. - P1-15 : рис., a-табл. - Bibliogr. : p. 14-15 (52 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRUS AGENT -- DENDRITIC CELL -- ALLERGY AND IMMUNOLOGY
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs

\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
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14.
Инвентарный номер: нет.
   
   D 44

   
    Dependence of the lymphocyte proliferative response on the endogenous cortisol level and sensitivity to β-adrenergic regulation in vitro in the early period of penetrating eye injury / V. A. Chereshnev, M. V. Chereshneva, Yu. I. Shilov, T. V. Gavrilova // Doklady Biological Sciences. - 2010. - Vol. 434, № 1. - P304-306. - Bibliogr. : p. 306 (10 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
CELL PROLIFERATION -- DRUG EFFECT -- EYE INJURY

\\\\expert2\\NBO\\Doklady Biological Sciences\\2010. V. 434, N 1.P. 304-306.pdf
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15.
Инвентарный номер: нет.
   
   F 33

   
    Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number / G. Bocharov, J. B. Quiel, T. B. Luzyanina [и др.] // Proceedings of the National Academy of Sciences of the United States of America. - 2011. - Vol. 108, № 8. - С. 3318-3323
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PARAMETER ESTIMATION -- TIME DELAY -- BROXURIDINE
Аннотация: The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain to be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) and factor of expansion (FE), with a slope of ∼-0.5 over a range of 3-30,000 precursors per mouse. The results suggested inhibition of precursor expansion either by competition for specific antigen-presenting cells or by the action of other antigen-specific cells in the same microenvironment as the most likely explanation. Several molecular mechanisms potentially accounting for such inhibition were examined and rejected. Here we adopt a previously proposed concept, "feedback-regulated balance of growth and differentiation," and show that it can explain the observed findings. We assume that the most differentiated effectors (or memory cells) limit the growth of less differentiated effectors, locally, by increasing the rate of differentiation of the latter cells in a dose-dependent manner. Consequently, expansion is blocked and reversed after a delay that depends on initial PN, accounting for the dependence of the peak of the response on that number. We present a parsimonious mathematical model capable of reproducing immunization response kinetics. Model definition is achieved in part by requiring consistency with available BrdU-labeling and carboxyfluorescein diacetate succinimidyl ester (CFSE)-dilution data. The calibrated model correctly predicts FE as a function of PN. We conclude that feedback-regulated balance of growth and differentiation, although awaiting definite experimental characterization of the hypothetical cells and molecules involved in regulation, can explain the kinetics of CD4 T-cell responses to antigenic stimulation

\\\\expert2\\nbo\\PNAS\\2011. - Vol.108, №8. - С. 3318-3323.pdf
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16.
Инвентарный номер: нет.
   Р
   Ф 24

   
    Фармакологическое регулирование программированной гибели клеток [] : монография / В. А. Черешнев, В. Н. Цыган, М. М. Одинак, А. М. Иванов ; редактор В. А. Черешнев ; Военно-медицинская академия. - Санкт-Петербург : Наука , 2011. - 253, [1] с. - Загл. на доп.тит.листе : Phrmacological regulation of programmed cell death. - Предм. указ.: с. 177-178. - Библиогр.: с. 179-248. - ISBN 978-5-02-037117-0 : Б. ц.
ГРНТИ
34.45
34.19
ББК Р281 + 570.5
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ--ФАРМАКОЛОГИЯ--ФАРМАЦИЯ--ТОКСИКОЛОГИЯ
   БИОЛОГИЧЕСКИЕ НАУКИ--ОБЩАЯ БИОЛОГИЯ

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17.
Инвентарный номер: нет.
   
   O-65

   
    Opportunmes of ripe dendritic cells with preparat containing humana-fetoprotein / O. V. Lebedinskaya, E. Lebedinskaya, T. V. Gavrilova [et al.] // The 12th International Symposium on Dendritic Cells, Daegu, Korea, 7-11 october 2012 : abstract. - Daegu, 2012. - P109
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
DENDRITIC CELL -- LEUKOCYTES -- FETOPROTEIN

\\\\expert2\\nbo\\12th Int. Symposium on Dendritic Cells\\2012. P01-40P. 109.pdf
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18.
Инвентарный номер: нет.
   
   T 10

   
    T cell apoptosis in HIV-infected patients with incomplete immune recovery after antiretroviral therapy [Electronic resource] / E. V. Saidakova, L. B. Korolevskaya, K. V. Shmagel, N. G. Shmagel, V. A. Chereshnev // Doklady Biological Sciences. - 2013. - Vol. 450, № 1. - P189-191. - Библиогр.: с. 191 (5 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIRETROVIRAL THERAPY -- HIV-INFECTED -- T CELL

\\\\expert2\\nbo\\Doklady Biological Sciences\\2013. V. 450, N 1. P. 189-191.pdf
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19.
Инвентарный номер: нет.
   
   I-56

   
    Impact of bacterial autoregulatory molecules (homoserine lactones and alkylhydroxybenzenes) on the oxidative metabolism of the cell effectors of natural immunity / D. G. Deryabin, T. G. Sviridova, G. I. El'-Registan, V. A. Chereshnev // Microbiology. - 2013. - Vol. 82, № 2. - P133-141
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ALKYLHYDROXYBENZENES -- CHEMOLUMINESCENCE -- HOMOSERINE LACTONES
Аннотация: We investigated the impact of bacterial regulators homoserine lactones (HSLs) and alkylhydroxybenzenes (AHBs) (which are present in human fluids at pico- and nanomolar concentrations) on neutrophile oxidative metabolism. The HSL and AHB effects were determined using a test based on induced luminol-dependent chemoluminescence of neutrophiles in human peripheral blood. In this test, neutrophiles were preincubated with chemical analogs of bacterial autoregulators with different lengths of the hydrocarbon radical, such as HSL · HCl, C6- and C12-HSL, and C1-, C6-, and C12-AHB. We revealed that they suppressed the chemoluminescence and, accordingly, the oxidative metabolism of neutrophiles. This effect was more significant with HSLs than with AHBs. Within each of the two groups, the effect increased with an increase in the length of the hydrocarbon chain of the homologues. High concentrations of long-chain autoregulators of both types produce a cytotoxic effect that is associated with apoptosis in the case of C12-HSL and with cell membrane damage in the case of C12-AHB. The effects of low HSL and AHB concentrations involve their protein-modifying properties and result in changes in the activities of neutrophile oxidative enzymes. To a lesser extent, these effects are due to the pro- and antioxidant activities of HSLs and AHBs, respectively. In light of the results obtained, the HSL and AHB effects are to be considered as a novel mechanism of regulating the activities of cell effectors of natural innate immunity. In symbiotic and parasitic systems, the mechanism involves the bimodal pattern of the effects of HSLs and AHBs that vary depending on their structure and concentrations

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20.
Инвентарный номер: нет.
   
   C 98

   
    Cytotoxicity of N-dodecanoyl-L-homoserine lactone and 5-N-dodecyl resorcinol to human granulocytes and monocytes: A comparative study [Electronic resource] / T. G. Sviridova, D. G. Deryabin, O. Cyganok, V. A. Chereshnev // Central European Journal of Immunology. - 2013. - Vol. 38, № 3. - P310-316. - Bibliogr. : p. 316 (21 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
5-N-DODECYL RESORCINOL -- CYTOTOXICITY -- APOPTOSIS
Аннотация: Small molecules originating from microbes (SMOMs) play a significant role in bacterial-bacterial communication and in interactions between bacteria and their hosts. The aim of this study is a comparative analysis of the cytotoxic activity to human granulocytes and monocytes of two structurally close SMOMs: N-dodecanoyl-L-homoserine lactone (C12-HSL) and 5-N-dodecyl resorcinol (C12-AR). Cell viability was determined by Trypan blue dye exclusion. To distinguish cell death mechanisms, both necrosis and apoptosis tests were carried out. Cells undergoing apoptosis were identified by caspase-3 activity and the level of histone-associated DNA fragments. To evaluate cell lysis, the lactate dehydrogenase release test was used. In addition, the SMOM's action on erythrocyte membrane stability was investigated. The investigated SMOMs in micromolar concentrations showed more dose-dependent cytotoxicity against granulocytes than monocytes, but they used different mechanisms to impinge on the cell death pathway. C12-HSL specifically induced apoptosis similar to the activity previously reported for 3-oxo-N-dodecanoyl-L- homoserine lactone that originated from Pseudomonas aeruginosa. In contrast, C12-AR induced fast cytolytic effects (necrosis) as shown by the release of cytoplasmic lactate dehydrogenase, and presumably were defined by cellular membrane destabilisation. Our data demonstrate that both C 12-HSL and C12-AR can eliminate key defence cells, which would otherwise participate in the destruction of pathogenic bacteria. These results reinforce the SMOMs bifunctionality concept that such bacterial molecules not only regulate bacterial-bacterial interactions but also break immune defences as a new and important mechanism of host evasion

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