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1.
Инвентарный номер: нет.
   


   
    Применение защитных белков теплового шока-70 для борьбы с COVID-19 / В. А. Черешнев, С. Б. Оникиенко, А. В. Земляной, С. В. Абкин // Журнал инфектологии. - 2022. - Т. 14, № 2, Приложение 1 : Материалы VIII Конгресса Евро-Азиатского общества по инфекционным болезням, Санкт-Петербург, 17-19 мая 2022. - С. 134-135
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
COVID 19 -- КОРОНАВИРУС -- ШОК ТЕПЛОВОЙ -- БЕЛКИ ЗАЩИТНЫЕ
Аннотация: We investigated the impact of bacterial regulators homoserine lactones (HSLs) and alkylhydroxybenzenes (AHBs) (which are present in human fluids at pico- and nanomolar concentrations) on neutrophile oxidative metabolism. The HSL and AHB effects were determined using a test based on induced luminol-dependent chemoluminescence of neutrophiles in human peripheral blood. In this test, neutrophiles were preincubated with chemical analogs of bacterial autoregulators with different lengths of the hydrocarbon radical, such as HSL · HCl, C6- and C12-HSL, and C1-, C6-, and C12-AHB. We revealed that they suppressed the chemoluminescence and, accordingly, the oxidative metabolism of neutrophiles. This effect was more significant with HSLs than with AHBs. Within each of the two groups, the effect increased with an increase in the length of the hydrocarbon chain of the homologues. High concentrations of long-chain autoregulators of both types produce a cytotoxic effect that is associated with apoptosis in the case of C12-HSL and with cell membrane damage in the case of C12-AHB. The effects of low HSL and AHB concentrations involve their protein-modifying properties and result in changes in the activities of neutrophile oxidative enzymes. To a lesser extent, these effects are due to the pro- and antioxidant activities of HSLs and AHBs, respectively. In light of the results obtained, the HSL and AHB effects are to be considered as a novel mechanism of regulating the activities of cell effectors of natural innate immunity. In symbiotic and parasitic systems, the mechanism involves the bimodal pattern of the effects of HSLs and AHBs that vary depending on their structure and concentrations

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2.
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   Ч-46


    Черешнев, Валерий Александрович.
    Оценка влияния бюджетных расходов на человеческое развитие регионов России / В. А. Черешнев, А. В. Васильева, А. Н. Тырсин // Экономика и предпринимательство. - 2016. - № 8. - С. 930-937
ББК 65
Рубрики: ЭКОНОМИКА. ЭКОНОМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ИНДЕКС ЧЕЛОВЕЧЕСКОГО РАЗВИТИЯ -- HUMAN DEVELOPMENT INDEX -- БЮДЖЕТНЫЕ РАСХОДЫ -- BUDGET EXPENSES -- РЕГИОН -- REGION -- РЕГРЕССИОННЫЙ АНАЛИЗ -- REGRESSION ANALYSIS
Аннотация: В статье анализируются особенности социально-экономического развития регионов России и отмечается их сильная дифференциация по уровню человеческого развития. Предложен и реализован подход к оценке количественной зависимости значения индекса человеческого развития от удельных (парциальных) бюджетных расходов субъектов РФ на основе корреляционно-регрессионного анализа. Сделан вывод о неэффективном расходовании бюджетных средств с позиции повышения региональных значений индекса человеческого развития.

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3.
Инвентарный номер: нет.
   
   C 51


    Chereshnev, V. A.
    Variable polyrhythmicity of processes in nature and society / V. A. Chereshnev, S. I. Stepanova, A. G. Gamburtsev // Herald of the Russian Academy of Sciences. - 2017. - Vol. 87, № 2. - P172-180. - Bibliogr. : p. 180 (15 ref.)
ББК 50 + 61
Рубрики: ЕСТЕСТВЕННЫЕ НАУКИ--НАУКА ОБ ОКРУЖАЮЩЕЙ СРЕДЕ--ЭКОЛОГИЯ В ЦЕЛОМ--КОНФЕРЕНЦИИ
   ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ

Кл.слова (ненормированные):
VARIABLE POLYRHYTHMICITY -- RHYTHMS IN NATURE AND SOCIETY -- TIME-SPECTRAL ANALYSIS
Аннотация: The authors discuss possible causes of the variable polyrhythmicity of processes in nature and society, particularly in geophysics. It may be caused by desynchronization or resynchronization of processes that manifest themselves as a result of a shock impact on the geological environment, for example, in the form of an earthquake. Medical parameters are considered for which de- and resynchronization of rhythmic processes in the human organism are known, as well as geophysical processes, including underground noise of tidal origin and the seismicity of the Moon.

\\\\expert2\\NBO\\Herald of the Russian Academy of Sciences\\2017. V. 87, N 2. P. 172-180.pdf
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4.
Инвентарный номер: нет.
   
   T67


   
    To preservation of the microbial biodiversity of a human organism / V. A. Chereshnev, A. A. Morova, M. V. Chereshneva, G. V. Ikonnikova // Microbial Diversity: current situation, conservation strategy and ecological aspects «COMID 96»: International Conference: abstracts. - Perm, 1996. - P. 156-157
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
МИКРОБИОЛОГИЯ МЕДИЦИНСКАЯ -- МИКРОБИОЛОГИЯ МЕДИЦИНСКАЯ (ВЫЖИВАНИЕ БАКТЕРИЙ)

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5.
Инвентарный номер: нет.
   
   T 44


   
    The role of monocytes in the effects of β-endorphin and selective agonists of μ-and δ-opiate receptors on the proliferative activity of peripheral blood lymphocytes / S. V. Gein, T. A. Baeva, O. N. Gein, V. A. Chereshnev // Human Physiology. - 2006. - Vol. 32, № 3. - P346-350
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
MONOCYTES -- BETA ENDORPHIN -- BLOOD LYMPHOCYTES
Аннотация: The effects of β-endorphin under the conditions of naloxone hydrochloride blockade of opiate receptors, as well as the effects of the selective agonists of μ-and δ-receptors DAGO and DADLE and the effects of melanocyte-potentiating factor (MPF), on the in vitro proliferative response of lymphocytes were studied. The dose-effect dependence indicated stimulating effects of β-endorphin, DAGO, and DADLE on the proliferative response in the presence of phytohemagglutinin (PHA). The tetrapeptide MPF, which is the C-terminal sequence of β-endorphin, had almost no effect on the proliferative activity of lymphocytes. β-Endorphin, naloxone, and the μ-and δ-receptor selective agonists enhanced the proliferative response of lymphocytes in an unfractionated cell culture, whereas β-endorphin, naloxone, and DAGO suppressed the proliferative activity of lymphocytes in the mononuclear fraction purified of monocytes. In both cases, the naloxone blockade of opiate receptors enhanced rather than eliminated the β-endorphin e

\\\\expert2\\nbo\\Human Physiology\\2006. V. 32, N 3. P. 346-350.pdf
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6.
Инвентарный номер: нет.
   
   N 89


   
    Novelties in the field of autoimmunity – 1st Saint Petersburg congress of autoimmunity, the bridge between east and west / Sh. Dahan, Y. Segal, A. Watad [et al.] // Autoimmunity Reviews. - 2017. - Vol. 16. - P1175-1184
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
AUTOIMMUNITY -- HUMAN PAPILLOMA VIRUS -- ALZHEIMER'S DISEASE -- INTRA VENOUS IMMUNOGLOBULINS -- PARANEOPLASTIC NEUROLOGICAL SYNDROME -- SYSTEMIC LUPUS ERYTHEMATOSUS -- ANTI-PHOSPHOLIPID SYNDROME

\\\\Expert2\\NBO\\Autoimmunity Reviews\\2017 V. 16 P. 1175-1184.pdf
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7.
Инвентарный номер: нет.
   


   
    Novel disease-associated missense single-nucleotide polymorphisms variants predication by algorithms tools and molecular dynamics simulation of human TCIRG1 gene causing congenital neutropenia and osteopetrosis / K. Shinwari, H. Rehman, H. Liu Guojun [et al.] // Frontiers in Molecular Biosciences. - 2022. - Vol. 9. - Ст. 879875
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: T Cell Immune Regulator 1, ATPase H + Transporting V0 Subunit A3 (TCIRG1 gene provides instructions for making one part, the a3 subunit, of a large protein complex known as a vacuolar H + -ATPase (V-ATPase). V-ATPases are a group of similar complexes that act as pumps to move positively charged hydrogen atoms (protons) across membranes. Single amino acid changes in highly conserved areas of the TCIRG1 protein have been linked to autosomal recessive osteopetrosis and severe congenital neutropenia. We used multiple computational approaches to classify disease-prone single nucleotide polymorphisms (SNPs) in TCIRG1. We used molecular dynamics analysis to identify the deleterious nsSNPs, build mutant protein structures, and assess the impact of mutation. Our results show that fifteen nsSNPs (rs199902030, rs200149541, rs372499913, rs267605221, rs374941368, rs375717418, rs80008675, rs149792489, rs116675104, rs121908250, rs121908251, rs121908251, rs149792489 and rs116675104) variants are likely to be highly deleterious mutations as by incorporating them into wild protein they destabilize the wild protein structure and function. They are also located in the V-ATPase I domain, which may destabilize the structure and impair TCIRG1 protein activation, as well as reduce its ATPase effectiveness. These mutants have not yet been identified in patients suffering from CN and osteopetrosis while (G405R, R444L, and D517N) reported in our study are already associated with osteopetrosis. Mutation V52L reported in our study was identified in a patient suspected for CN. Finally, these mutants can help to further understand the broad pool of illness susceptibilities associated with TCIRG1 catalytic kinase domain activation and aid in the development of an effective treatment for associated diseases.

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8.
Инвентарный номер: нет.
   
   M 39


   
    Mathematical modelling of the within-host HIV quasispecies dynamics in response to antiviral treatment [Text] / G. A. Bocharov, I. S. Telatnikov, V. A. Chereshnev [et al.] // Russian Journal of Numerical Analysis and Mathematical Modelling. - 2015. - Vol. 30, № 3. - P157-170 : il. - Bibliogr. : p. 169-170 (29 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
MATHEMATICAL MODEL -- HUMAN IMMUNODEFICIENCY VIRUS -- GENETIC ALGORITHM -- QUASISPECIES -- VIRUS INFECTION
Аннотация: The aim of this work is the construction, calibration, and comparative analysis of mathematical models of the evolution of the human immunodeficiency virus (HIV) in the course of infection when the models are based on deterministic principles of the quasispecies theory (Eigen-Schuster) and on stochastic approaches of genetic algorithms (Holland). The models take into account the replication of viral genomes and selection of descendants according to their fitness, point mutations, multi-infection of target cells and recombination of genomes at the stage of formation of proviral DNA. The processes of diversification of the virus population under the action of the antiviral drug azidothymidine (AZT) that blocks reverse transcription of the virus are simulated. A four-letter alphabet is used in the stochasticmodel for description of nucleotide sequences. The parameters of the model are estimated using original data on the degree of adaptation of the HIV mutants that are partly or completely resistant to this drug. The influence of parameters of infection on the characteristics of viral mutants population diversity is studied

\\\\expert2\\nbo\\Russian Journal of Numerical Anal. and Math. Modelling\\2015. V.30, N. 3. P. 157-170.pdf
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9.
Инвентарный номер: нет.
   
   I-70


   
    Investigation of immune system functioning and development of methods for immune correction therapy of workers from defence industry (Leveling of unfavorable effects from ionizing radiation and toxic chemical compounds on a human body) / B. A. Bachmetyev, V. A. Chereshnev, N. N. Kevorkov, S. V. Shirshev // Scientific-technical potential of the Western Urals for conversion of military industrial complex: proceedings. - Perm, 2001. - P168-171
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
IMMUNE SYSTEM

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Scientific-technical potential, 2001 P. 168-171.pdf
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10.
Инвентарный номер: нет.
   
   I-57


   
    In vitro cytokine stimulation assay for glycolipid biosurfactant from Rhodococcus ruber: Role of monocyte adhesion / S. V. Gein, M. S. Kuyukina, I. B. Ivshina, V. A. Chereshnev // Cytotechnology. - 2011. - Vol. 63, № 6. - P559-566. - Bibliogr. : p. 565-566 (23 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
CYTOKINE-STIMULATING ACTIVITY -- GLYCOLIPID BIOSURFACTANT -- MONOCYTE ADHESION
Аннотация: Glycolipid biosurfactant (GLB) from Rhodococcus ruber IEGM 231 was found to stimulate tumor necrosis factor-α (TNF-α), interleukin (IL) -1β and IL-6 production when applied as an ultrasonic emulsion to the adherent human peripheral blood monocyte culture. However, a lack of cytokine-stimulating activity was registered with the GLB applied as a hydrophobic film coating in 24-well culture plates, indicating that it may have been due to its inhibitory effect on monocyte adhesion. The mode of GLB application may therefore play an important role in in vitro assay of immunostimulatory activity of this compound as well as other bacterial glycolipids. Additionally, GLB from R. ruber displayed no cytotoxicity against human lymphocytes and therefore could be proposed as a potential immunomodulating and antitumor ag

\\\\expert2\\NBO\\Cytotechnology\\2011. V. 63, N 6. P. 559-566.pdf
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