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1.

Вид документа : Статья из журнала
Шифр издания : 61/П 20
Автор(ы) : Черешнев В. А., Гаврилова Т. В., Файзрахманов Р. Р., Крохина Н. Б., Медведева С. Ю., Черешнева М. В., Шилов Ю. И., Родионов С. Ю.
Заглавие : Патоморфологическая характеристика травматического воспаления и репаративных процессов в роговице при экспериментальном проникающем ранении глаза в условиях иммуномодулирующей терапии
Место публикации : Пермский медицинский журнал. - 2008. - Т. 25, № 3. - С. 54-58
Примечания : Библиогр.: с. 58 (10 назв.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): травматическое воспаление --роговица--иммуномодулирующая терапия
Аннотация: The study of the effect of novel native immune modulator profetal (alphafetoprotein) as an active substance on the course of traumatic inflammation and reparative processes has been performed with experimental-biological model of penetrating wound of the eye in 36 Wistar rats. Histological and morphometric methods were used in this work. Profetal was applied alone and in combination with conventional therapy including glucocorticoids, antibiotics and non-steroid anti-inflammatory preparations. It was determined that the use of profetal both as monotherapeutic variant and in combined treatment suppressed the development of wound scarring and induced the processes of tissue defect recovery via reparative regeneration.
\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Пермский медицинский журнал\\2008. Т. 25, №3. С. 54-58.pdf
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2.

Вид документа : Статья из журнала
Шифр издания : 61/В 58
Автор(ы) : Черешнев В. А., Шилов Ю. И., Черешнева М. В., Гаврилова Т. В., Файзрахманов Р. Р., Крохина Н. Б., Медведева С. Ю., Родионов С. Ю.
Заглавие : Влияние "профеталя" ® на морфологические проявления травматического воспаления при экспериментальном проникающем ранении глаза
Место публикации : Морфологические ведомости. - 2008. - Т. 1, № 3-4. - С. 83-86
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): профеталь--проникающее ранение глаза--воспаление (исследования)
Аннотация: The study of the effect of novel native immune modulator profetal (alpha fetoprotein as an active substance) on the course of traumatic inflammation and reparative processes has been made with experimental biological model of eye penetrating wound in 91 Wistar male rats. Histological and morphometric methods were used in this work. Profetal was applied both single and in combination with conventional therapy, including glucocorticoids, antibiotics, and non steroid anti inflammatory preparations. It was determined that the use of profetal both as monotherapeutic variant and in combined treatment suppressed the development of wound scarring and induced the processes of tissue defect recovery via reparative regeneration.
\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Морфологические ведомости\\2008. Т.1, №3-4. С. 83-86.pdf
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3.

Вид документа : Статья из журнала
Шифр издания : 61/Z 86
Автор(ы) : Zotova N. V., Chereshnev V. A., Gusev E. Yu.
Заглавие : Systemic inflammation: methodological approaches to identification of the common pathological process
Место публикации : PLOS One. - 2016. - Vol. 11, № 5. - С. P. e0155138
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): multi-syndrome--pathological process
Аннотация: We defined Systemic inflammation (SI) as a “typical, multi-syndrome, phase-specific pathological process, developing from systemic damage and characterized by the total inflammatory reactivity of endotheliocytes, plasma and blood cell factors, connective tissue and, at the final stage, by microcirculatory disorders in vital organs and tissues.” The goal of the work: to determine methodological approaches and particular methodical solutions for the problem of identification of SI as a common pathological process. SI can be defined by the presence in plasma of systemic proinflammatory cell stress products—cytokines and other inflammatory mediators, and also by the complexity of other processes signs. We have developed 2 scales: 1) The Reactivity Level scale (RL)–from 0 to 5 points: 0-normal level; RL-5 confirms systemic nature of inflammatory mediator release, and RL- 2–4 defines different degrees of event probability. 2) The SI scale, considering additional criteria along with RL, addresses more integral criteria of SI: the presence of ≥ 5 points according to the SI scale proves the high probability of SI developing. To calculate the RL scale, concentrations of 4 cytokines (IL-6, IL-8, IL-10, TNF-α) and C-reactive protein in plasma were examined. Additional criteria of the SI scale were the following: D-dimers500ng/ml, cortisol1380 or 100nmol/l, troponin I≥0.2ng/ml and/or myoglobin≥800ng/ml. 422 patients were included in the study with different septic (n-207) and aseptic (n-215) pathologies. In 190 cases (of 422) there were signs of SI (lethality 38.4%, n-73). In only 5 of 78 cases, lethality was not confirmed by the presence of SI. SI was registered in 100% of cases with septic shock (n-31). There were not significant differences between AU-ROC of CR, SI scale and SOFA to predict death in patients with sepsis and trauma.
\\\\expert2\\NBO\\PLoS ONE\\2016, v.11, p. e0155138pdf.pdf
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4.

Вид документа : Статья из журнала
Шифр издания : 61/T 44
Автор(ы) : Saidakova E. V., Korolevskaya L. B., Shmagel K. V., Shmagel N. G., Chereshnev V. A., Lederman M. M.
Заглавие : The role of systemic inflammation in the formation of CD4+T cell deficiency in HIV/HCV coinfection
Место публикации : International Journal of Rheumatic Diseasis. - 2014. - Vol. 17, Suppl. 2. - С. 17-18
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): inflammation--coinfection--cd4+t
\\\\expert2\\nbo\\International Journal of Rheumatic Diseases\\2014. V. 17, Suppl. 2. P. 17-18.pdf
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5.

Вид документа : Статья из журнала
Шифр издания : 61/T 44
Автор(ы) : Chereshnev V. A., Chereshneva M. V., Shilov Yu. I., Medvedeva, S.Y., Khonina N. B., Shilov S. Yu., Gavrilova T. V.
Заглавие : The effect of polyoxidonium on immune response and morphological parameters of inflammation after experimental penetrating eye injury
Место публикации : Doklady Biological Sciences. - 2012. - Vol. 443, № 1. - С. 75-77
Примечания : Bibliogr. : p. 77 (10 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): azoximer bromide--dexamethasone--heterophile antigen
\\\\expert2\\NBO\\Doklady Biological Sciences\\2012. V. 443, N 1. P. 75-77.pdf
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6.

Вид документа : Статья из журнала
Шифр издания : 61/S 98
Автор(ы) : Shmagel K. V., Saidakova E. V., Shmagel N. G., Korolevskaya L. B., Chereshnev V. A., Robinson J., Grivel J-C., Douek D. C., Margolis L., Anthony D. D., Lederman M. M.
Заглавие : Systemic inflammation and liver damage in HIV/hepatitis C virus coinfection
Место публикации : HIV Medicine. - 2016. - Vol. 17, № 8. - С. 581-589
Примечания : Bibliogr. : p. 7-9 (40 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): antigens--hepatitis c--hiv infection
\\\\expert2\\NBO\\HIV Medicine\\2016. 1-9.pdf
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7.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gusev E., Sarapultsev A., Solomatina L., Chereshnev V.
Заглавие : SARS-Cov-2-specific immune response and the pathogenesis of Covid-19
Место публикации : International journal of molecular sciences. - 2022. - Vol. 23, № 3. - Ст.1716
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): коронавирус--covid 19--autoimmunity--adaptive immunity--cellular stress--sars-cov-2;
Аннотация: The review aims to consolidate research findings on the molecular mechanisms and virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and their relevance to four typical stages in the development of acute viral infection. These four stages are invasion; primary blockade of antiviral innate immunity; engagement of the virus’s protection mechanisms against the factors of adaptive immunity; and acute, long-term complications of COVID-19. The invasion stage entails the recognition of the spike protein (S) of SARS-CoV-2 target cell receptors, namely, the main receptor (angiotensin-converting enzyme 2, ACE2), its coreceptors, and potential alternative receptors. The presence of a diverse repertoire of receptors allows SARS-CoV-2 to infect various types of cells, including those not expressing ACE2. During the second stage, the majority of the polyfunctional structural, non-structural, and extra proteins SARS-CoV-2 synthesizes in infected cells are involved in the primary blockage of antiviral innate immunity. A high degree of redundancy and systemic action characterizing these pathogenic factors allows SARS-CoV-2 to overcome antiviral mechanisms at the initial stages of invasion. The third stage includes passive and active protection of the virus from factors of adaptive immunity, overcoming of the barrier function at the focus of inflammation, and generalization of SARS-CoV-2 in the body. The fourth stage is associated with the deployment of variants of acute and long-term complications of COVID-19. SARS-CoV-2’s ability to induce autoimmune and autoinflammatory pathways of tissue invasion and development of both immunosuppressive and hyperergic mechanisms of systemic inflammation is critical at this stage of infection.
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8.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Sobolevskaya P. A., Gvozdeckii A. N., Kudryavtsev I. V., Chereshnev V. A., Сhurilov L. P.
Заглавие : Role of proinflammatory cytokines in hashimoto's thyroiditis associated with psychiatric disorders
Место публикации : Medical Immunology. - 2023. - Vol. 25, № 5. - С. 1247-1252
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Mental disorders often accompany autoimmune diseases, for example, since 1949 it has been known about “myxedematous madness”, a psychosis caused by hypothyroidism. The most common cause of hypothyroidism is Hashimoto's autoimmune thyroiditis. It is also known about another neuropsychiatric disorder associated with autoimmune thyroiditis, Hashimoto's encephalopathy. It is a severe dysfunction of the central nervous system, the pathogenesis of which is not associated with hormonal disorders. Cytokines are regulators and participants of inflammation, including autoimmune. Certainly, when we are talking about high concentrations cytokines, we mean systemic inflammation. The minimal or mediocre fluctuations in cytokines within the ranges that are characteristic of healthy status or normergic acute phase response in disease cannot be interpreted from the point of view of binary endocrinological logic. In the CNS, cytokines are able to influence on the neuroendocrine control of systemically regulated functions. It is also important that glial cells (astroglia, microglia) are capable of producing a number of cytokines and can affect neurons and develop behavioral changes. In addition, the ability of a number of cytokines outside the CNS itself to act on vagal afferents and through them to convey information to the CNS, affecting its state and functions, has been proven. It is reasonable to assume that minimal fluctuations in cytokine levels may also affect the state and function of the CNS. The aim of the study was to investigate the levels of cytokines in patients with thyroiditis; in patients with thyroiditis associated with mental disorders; in a group of healthy individuals; and evaluate the effect of cytokine levels on clinical manifestations. In the group of patients with thyroiditis and mental disorders, the levels of CCL20/MIP3α, IL-13, IL-2, IL-27, IL-5 were significantly higher than in other groups. At the same time, no positive correlation was found between the clinical manifestations of mental disorders and the levels of cytokines. A positive correlation was found between the levels of some cytokines and free triiodothyronine, as well as the level of antithyroid antibodies. Mental disorders associated with autoimmune thyroiditis may be associated with changes in the cytokine profile and result from neuroinflammation.
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9.

Вид документа : Статья из сборника (однотомник)
Шифр издания : 61/L 83
Автор(ы) : Shmagel K. V., Saidakova E. V., Shmagel N. G., Korolevskaya L. B., Chereshnev V. A.
Заглавие : Liver damage and inflammation in HIV/hepatitis C virus coinfection
Место публикации : Глобальное партнерство в борьбе с ВИЧ/СПИДом. Ценна каждая жизнь : тезисы пятой конференции по ВИЧ/СПИДу в Восточной Европе и Центральной Азии. - Москва, 2016. - С. 278-279
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): hiv/hepatitis --liver damage
\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Тезисы 5 конференции по СПИДУ 2016-Abstracts P. 278-279.pdf
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10.

Вид документа : Статья из сборника (однотомник)
Шифр издания : 61/I-69
Автор(ы) : Yurchenko L. N., Gusev E. Y., Chereshnev V. A., Zotova N. V., Kopalova J. A., Sukhanov V. A.
Заглавие : Integral indexes of cytocinemia as a means to estimate critical states
Место публикации : Cytokines and Inflammation : abstracts GTCbio’s 5- th conference, Breckenridge, Colorado, January 29-30 2007. - Breckenridge, 2007. - С. 55
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): critical states --cytocinemia--cellular immunity
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