Центральная Научная Библиотека УрО РАН

Вид документа : Статья из журнала
Шифр издания : 57/I-57
Автор(ы) : Kuyukina M. S., Ivshina I. B., Gein S. V., Chereshnev V. A.
Заглавие : In vitro immunomodulating activity of biosurfactant glycolipid complex from Rhodococcus ruber
Место публикации : Herald of the Russian Academy of Sciences. - 2007. - Vol. 77, № 5. - С. 326-330
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): actinobacteria--rhodococcus ruber--biosurfactant
Аннотация: The biosurfactant glycolipid complex synthesized by Rhodococcus ruber actinobacteria is not toxic and exhibits no appreciable effect on proliferative activity of peripheral blood leukocytes. In the monocyte fraction, the biosurfactant activates the production of IL-1 beta and TNF-alpha cytokines without modifying the production of IL-6. In the mononuclear fraction, the glycolipid biosurfactant exhibited no effects on the production of IL-1 beta, TNF-alpha, and IL-6. These results indicate good prospects for further studies of immunomodulating and antitumor activities of biosurfactant drug
\\\\Expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2007, v.144, N 3, p. 326.pdf
Найти похожие

Вид документа : Статья из журнала
Шифр издания : 61/I-57
Автор(ы) : Gein S. V., Kuyukina M. S., Ivshina I. B., Chereshnev V. A.
Заглавие : In vitro cytokine stimulation assay for glycolipid biosurfactant from Rhodococcus ruber: Role of monocyte adhesion
Место публикации : Cytotechnology. - 2011. - Vol. 63, № 6. - С. 559-566
Примечания : Bibliogr. : p. 565-566 (23 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): cytokine-stimulating activity--glycolipid biosurfactant--monocyte adhesion
Аннотация: Glycolipid biosurfactant (GLB) from Rhodococcus ruber IEGM 231 was found to stimulate tumor necrosis factor-α (TNF-α), interleukin (IL) -1β and IL-6 production when applied as an ultrasonic emulsion to the adherent human peripheral blood monocyte culture. However, a lack of cytokine-stimulating activity was registered with the GLB applied as a hydrophobic film coating in 24-well culture plates, indicating that it may have been due to its inhibitory effect on monocyte adhesion. The mode of GLB application may therefore play an important role in in vitro assay of immunostimulatory activity of this compound as well as other bacterial glycolipids. Additionally, GLB from R. ruber displayed no cytotoxicity against human lymphocytes and therefore could be proposed as a potential immunomodulating and antitumor ag
\\\\expert2\\NBO\\Cytotechnology\\2011. V. 63, N 6. P. 559-566.pdf
Найти похожие

Вид документа : Статья из журнала
Шифр издания : 57/T 44
Автор(ы) : Gein S. V., Baeva T. A., Gein O. N., Chereshnev V. A.
Заглавие : The role of monocytes in the effects of β-endorphin and selective agonists of μ-and δ-opiate receptors on the proliferative activity of peripheral blood lymphocytes
Место публикации : Human Physiology. - 2006. - Vol. 32, № 3. - С. 346-350
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): monocytes--beta endorphin--blood lymphocytes
Аннотация: The effects of β-endorphin under the conditions of naloxone hydrochloride blockade of opiate receptors, as well as the effects of the selective agonists of μ-and δ-receptors DAGO and DADLE and the effects of melanocyte-potentiating factor (MPF), on the in vitro proliferative response of lymphocytes were studied. The dose-effect dependence indicated stimulating effects of β-endorphin, DAGO, and DADLE on the proliferative response in the presence of phytohemagglutinin (PHA). The tetrapeptide MPF, which is the C-terminal sequence of β-endorphin, had almost no effect on the proliferative activity of lymphocytes. β-Endorphin, naloxone, and the μ-and δ-receptor selective agonists enhanced the proliferative response of lymphocytes in an unfractionated cell culture, whereas β-endorphin, naloxone, and DAGO suppressed the proliferative activity of lymphocytes in the mononuclear fraction purified of monocytes. In both cases, the naloxone blockade of opiate receptors enhanced rather than eliminated the β-endorphin e
\\\\expert2\\nbo\\Human Physiology\\2006. V. 32, N 3. P. 346-350.pdf
Найти похожие

Вид документа : Статья из журнала
Шифр издания : 57/A 88
Автор(ы) : Shirshev S. V., Bakhmet'ev B. A., Chereshnev V. A., Lopatina V. A., Zamorina S. A.
Заглавие : Assessment of the immune status of women working in the potassium salt industry and their children
Место публикации : Russian Journal of Ecology. - 2003. - Vol. 34, № 6. - С. 432-437
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): immune system--potassium salt industry--oao sil'vinit
Аннотация: The state of the immune system was studied in the women working at the OAO Uralkalii (Berezniki) and OAO Sil'vinit (Solikamsk), where they were permanently exposed to salts and halite waste, and their children born after at least three years of such exposure. The control group consisted of women who had no occupational contact with salts and halite wastes and of their children. No significant differences between the differential leukocyte counts and immunograms of the women working at the OAO Uralkalii and OAO Sil'vinit and their children were found. The main parameters of the immune system of women and their children both in the first and second groups were within the norm
\\\\expert2\\nbo\\Russian Journal of Ecology\\2003. V. 34, N 6. P. 432-437.pdf
Найти похожие

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shinwari K., Wu Y., Rehman H., Xiao N., Bolkov M., Tuzankina I., Chereshnev V.
Заглавие : In-silico assessment of high-risk non-synonymous SNPs in ADAMTS3 gene associated with Hennekam syndrome and their impact on protein stability and function
Место публикации : BMC Bioinformatics. - 2023. - Vol. 24. - Ст.251
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Hennekam Lymphangiectasia–Lymphedema Syndrome 3 (HKLLS3) is a rare genetical disorder caused by mutations in a few genes including ADAMTS3. It is characterized by lymphatic dysplasia, intestinal lymphangiectasia, severe lymphedema and distinctive facial appearance. Up till now, no extensive studies have been conducted to elucidate the mechanism of the disease caused by various mutations. As a preliminary investigation of HKLLS3, we sorted out the most deleterious nonsynonymous single nucleotide polymorphisms (nsSNPs) that might affect the structure and function of ADAMTS3 protein by using a variety of in silico tools. A total of 919 nsSNPs in the ADAMTS3 gene were identified. 50 nsSNPs were predicted to be deleterious by multiple computational tools. 5 nsSNPs (G298R, C567Y, A370T, C567R and G374S) were found to be the most dangerous and can be associated with the disease as predicted by different bioinformatics tools. Modelling of the protein shows it can be divided into segments 1, 2 and 3, which are connected by short loops. Segment 3 mainly consists of loops without substantial secondary structures. With prediction tools and molecular dynamics simulation, some SNPs were found to significantly destabilize the protein structure and disrupt the secondary structures, especially in segment 2. The deleterious effects of mutations in segment 1 are possibly not from destabilization but from other factors such as the change in phosphorylation as suggested by post-translational modification (PTM) studies. This is the first-ever study of ADAMTS3 gene polymorphism, and the predicted nsSNPs in ADAMST3, some of which have not been reported yet in patients, will serve for diagnostic purposes and further therapeutic implications in Hennekam syndrome, contributing to better diagnosis and treatment.
https://link.springer.com/article/10.1186/s12859-023-05361-6
Найти похожие

Вид документа : Статья из журнала
Шифр издания : 61/E 27
Автор(ы) : Korolevskaya L. B., Shmagel K. V., Saidakova E. V., Shmagel N. G., Slobodchikova S. V., Chereshnev V. A.
Заглавие : Effect of hepatitis C vIrus coinfection on the content of CD4+ and CD8+ T cell subpopulations in HIV-infected patients receiving antiretroviral therapy
Место публикации : Bulletin of experimental biology and medicine. - 2016. - Vol. 161, № 2. - С. 281-283
Примечания : Bibliogr. : p. 283 (12 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ-- КЛИНИЧЕСКАЯ МЕДИЦИНА
Ключевые слова (''Своб.индексиров.''): hiv infection --hcv coinfection --antiretroviral therapy--t cell subpopulations
Аннотация: We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4+ T cells and an increase in the count of central CD8+ memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4+ memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.
\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2016, v.161, N 2, p. 281-283.pdf
Найти похожие

Вид документа : Однотомное издание
Шифр издания :
Автор(ы) : Zhou H., Zhang Z., Dobrinina M., Dong Y., Kang Z., Chereshnev V., Hu D., Zhang Z., Zhang J., Sarapultsev A.
Заглавие : Urinalysis, but not blood biochemistry, detects the early renal impairment in patients with COVID-19
Место публикации : Diagnostics. - 2022. - Vol. 12, № 3. - Ст.602 (13 pp.)
Ключевые слова (''Своб.индексиров.''): covid 19--коронавирус--urinalysis
Аннотация: Coronavirus 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), has created a tremendous economic and medical burden. The prevalence and prognostic value of SARS-CoV-2-induced kidney impairment remain controversial. The current study aimed to provide additional evidence on the incidence of acute kidney injury (AKI) in COVID-19 patients and propose the use of urinalysis as a tool for screening kidney impairment. Methods: 178 patients with confirmed COVID-19 were enrolled in this retrospective cohort study. The laboratory examinations included routine blood tests, blood biochemical analyses (liver function, renal function, lipids, and glucose), blood coagulation index, lymphocyte subset and cytokine analysis, urine routine test, C-reactive protein, erythrocyte sedimentation, and serum ferritin. Results: No patient exhibited a rise in serum creatinine or Cystatin C and occurrence of AKI, and only 2.8% of patients were recorded with an elevated level of blood urea nitrogen among all cases. On the contrary, 54.2% of patients who underwent routine urine testing presented with an abnormal urinalysis as featured by proteinuria, hematuria, and leucocyturia. Conclusions: Kidney impairment is prevalent among COVID-19 patients, with an abnormal urinalysis as a clinical manifestation, implying that a routine urine test is a stronger indication of prospective kidney complication than a blood biochemistry test.
Найти похожие

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Sobolevskaya P. A., Gvozdeckii A. N., Kudryavtsev I. V., Chereshnev V. A., Сhurilov L. P.
Заглавие : Role of proinflammatory cytokines in hashimoto's thyroiditis associated with psychiatric disorders
Место публикации : Medical Immunology. - 2023. - Vol. 25, № 5. - С. 1247-1252
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Mental disorders often accompany autoimmune diseases, for example, since 1949 it has been known about “myxedematous madness”, a psychosis caused by hypothyroidism. The most common cause of hypothyroidism is Hashimoto's autoimmune thyroiditis. It is also known about another neuropsychiatric disorder associated with autoimmune thyroiditis, Hashimoto's encephalopathy. It is a severe dysfunction of the central nervous system, the pathogenesis of which is not associated with hormonal disorders. Cytokines are regulators and participants of inflammation, including autoimmune. Certainly, when we are talking about high concentrations cytokines, we mean systemic inflammation. The minimal or mediocre fluctuations in cytokines within the ranges that are characteristic of healthy status or normergic acute phase response in disease cannot be interpreted from the point of view of binary endocrinological logic. In the CNS, cytokines are able to influence on the neuroendocrine control of systemically regulated functions. It is also important that glial cells (astroglia, microglia) are capable of producing a number of cytokines and can affect neurons and develop behavioral changes. In addition, the ability of a number of cytokines outside the CNS itself to act on vagal afferents and through them to convey information to the CNS, affecting its state and functions, has been proven. It is reasonable to assume that minimal fluctuations in cytokine levels may also affect the state and function of the CNS. The aim of the study was to investigate the levels of cytokines in patients with thyroiditis; in patients with thyroiditis associated with mental disorders; in a group of healthy individuals; and evaluate the effect of cytokine levels on clinical manifestations. In the group of patients with thyroiditis and mental disorders, the levels of CCL20/MIP3α, IL-13, IL-2, IL-27, IL-5 were significantly higher than in other groups. At the same time, no positive correlation was found between the clinical manifestations of mental disorders and the levels of cytokines. A positive correlation was found between the levels of some cytokines and free triiodothyronine, as well as the level of antithyroid antibodies. Mental disorders associated with autoimmune thyroiditis may be associated with changes in the cytokine profile and result from neuroinflammation.
Найти похожие

Сиглы отделов ЦНБ УрО РАН

  бр.ф. - Бронированный фонд

  бф - Научно-библиографический отдел

  БХЛ - Фонд художественной литературы

  ИИиА -Фонд исторической литературы в ЦНБ УрО РАН

  ИМЕТ -Отдел ЦНБ в Институте металлургии УрО РАН

  кх - Отдел фондов (книгохранениe)

  МБА - Межбиблиотечный абонемент

  мф - Методический фонд

  ок - Отдел научной каталогизации

  оку - Отдел комплектования и учета

  орф - Обменно-резервный фонд

  пф - Читальный зал деловой и патентной информации

  рк - Фонд редкой книги

  ч/з - Главный читальный зал

  эр - Зал электронных ресурсов

Сиглы библиотек институтов и НЦ УрО РАН

© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)