Центральная Научная Библиотека УрО РАН

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   A 53


    An extremal shift method for control of HIV infection dynamics / G. Bocharov, A. V. Kim, A. V. Krasovskii [et al.] // Russian Journal of Numerical Analysis and Mathematical Modelling . - 2015. - Vol. 30, № 1. - P11-25

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
HIV INFECTION -- OPTIMAL OPEN-LOOP CONTROL -- EXTREMAL SHIFT METHOD
Аннотация: Optimal control problems for mathematical models describing HIV infection dynamics in a human body are considered in the paper. An overview of current approaches to solution of control problems for models of HIV dynamics is presented for techniques related to construction of optimal programme (open loop) or positional (feedback) controls for various criteria of control process quality and is based on the Pontryagin's maximum principle and the Bellman's theory of dynamic programming, respectively. In the framework of the theory of positional differential games of Krasovskii, there are constructive and efficient methods of synthesis of controls for different classes of dynamical systems. In this paper we present a formalization of a control problem for HIV infection considered as a corresponding positional differential game. The control algorithm based on the method of extremal shift is applied to the ODEs model of HIV infection. The numerical implementation of the extremal shift method is developed to construct the control taking the system to a neighbourhood of a given trajectory using the information on the dynamics of the guides or leaders.

\\\\expert2\\nbo\\Russian Journal of Numerical Anal. and Math. Modelling\\2015. V.30, N. 1. P. 11-30.pdf
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   M 39


    Mathematical model of the Tat-Rev regulation of HIV-1 replication in an activated cell predicts the existence of oscillatory dynamics in the synthesis of viral components / V. Likhoshvai, T. Khlebodarova, S. Bazhan [et al.] // BMC Genomics. - 2014. - Vol. 15, Suppl. 12. - P1-18

ББК 57 + 61
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ --КЛИНИЧЕСКАЯ МЕДИЦИНА
Кл.слова (ненормированные):
HIV-1 REPLICATION -- OSCILLATORY DYNAMICS -- VIRAL COMPONENTS

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   N 52


    New capacities of the phagocytic test used in pediatric phthisiology / L. P. Sanakoeva, A. D. Koriukina, V. A. Chereshnev, V. A. Aksenova // Probl Tuberk Bolezn Legk . - 2004. - №6. - P42-48

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
BCG VACCINE -- LUNG TUBERCULOSIS -- PHAGOCYTOSIS
Аннотация: The paper presents the results of a study of the phagocytic activity of leukocytes (PAL) in 98 healthy children, vaccinated with BCG, in different periods after immunization and in 68 children with tuberculous infection (39 children with tuberculosis and 29 Mycobacterium tuberculosis-infected children). An improved procedure for studying PAL was used, in which sheep erythrocytes of two types ("antigenic" and those with a complex of antigen + antibody + antigen), which may differentiate the phase of bacteremia and immune synthesis, were used as an object for phagocytes. In the limited number of vaccinated children, bacteremia were detectable up to 9 months; the phase of immune synthesis continued in most children up to 3 years. The study has demonstrated that a complex of phagocytic tests may be used for the early diagnosis of tuberculous infection, for the evaluation of a tuberculous process and antituberculous immunity

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   S 98


    Synthesis of new 1,3,4-thiadiazines capable of inhibiting nonenzymatic glycosylation of proteins / L. P. Sidorova, T. A. Tseitler, N. M. Perova [et al.] // Pharmaceutical Chemistry Journal. - 2015. - Vol. 49, № 8. - P501-505. - Bibliogr. : p. 505 (12 ref.)

ББК 61 + 54
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
1,3,4-THIADIAZINE -- CYCLOCONDENSATION -- NONENZYMATIC GLYCOSYLATION OF PROTEINS -- THIOSEMICARBAZIDES
Аннотация: A series of new 1,3,4-thiadiazines with cycloalkylamino (cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino) groups were synthesized via cyclocondensation of α-haloacetophenones with thiosemicarbazides containing 4-cycloalkyl groups. Five of the synthesized compounds showed the capability to inhibit nonenzymatic glycosylation of proteins in vitro in a model system. The obtained test results allowed compounds containing cyclopropylamino residues (LT-1a and LT-1d) to be recommended for further in vivo testing

\\\\expert2\\nbo\\Pharmaceutical Chemistry Journal\\2015, 49 (8), 501-505.pdf
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   В 58


    Влияние биосурфактантного гликолипидного комплекса R. RUBER ИЕГМ 231 на секреторную активность эффекторов врожденного иммунитета / С. В. Гейн, Т. А. Баева, М. Куюкина, И. Б. Ившина, В. А. Черешнев // Вестник Уральской медицинской академической науки. - 2008. - № 4. - С. 48-51. - Библиогр.: с. 50 (12 назв.)

ББК Ч2
Рубрики: НАУКА. НАУКОВЕДЕНИЕ
Кл.слова (ненормированные):
R. RUBER -- ИЕГМ 231 -- ВРОЖДЕННЫЙ ИММУНИТЕТ
Аннотация: It is shown that in monocyte fraction the biosurfactant glycolipid complex of R. ruber IEGM 231 promotes the pro duction of IL-1β and TNF-α cytokines while unaffecting the IL-6 synthesis. The glycolipid biosurfactant effect on IL-1β, TNF-α, and IL-6 synthesis was not registered in mononuclear fraction. In neutrophil fraction the preparation was found to enhance the IL-8 production and did not change the IL-lβ and TNF-α secretion. The results obtained indicate the availability of further research of immune modulating and antitumor activity of biosurfactant preparation.

\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Вестник Уральской медицинской академической науки\\2008. № 4. С. 48-51.pdf
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