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1.
Инвентарный номер: нет.
   
   C 51


    Chereshnev, V. A.
    [Fundamental-applied aspects of systemic inflammation in terms of physiologic and typical pathological process]. / V. A. Chereshnev, E. I. Gusev, N. V. Zotova // Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk . - 2010. - Vol.96, №7. - С. 696-707
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
PATHOLOGY -- PATHOPHYSIOLOGY -- BIOLOGICAL MODEL
Аннотация: The concept of systemic inflammatory response syndrome (SIRS) by sepsis as well as quality of SIRS criteria, classification, and PIRO system has been a subject to analytical criticism in terms of theory of physiologic and typical pathological process. It has been disclosed SIRS can be considered only as the syndrome, that solves particular clinical tasks, but not as a basic model of pathogenesis of critical states. In authors' opinion it is more correctly to discuss systemic inflammation as a typical pathologic process that appears as a complex of one or another "resuscitation" syndrome in a clinical course

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2.
Инвентарный номер: нет.
   
   I-69


   
    Integral indexes of cytocinemia as a means to estimate critical states / L. N. Yurchenko, E. Y. Gusev, V. A. Chereshnev [et al.] // Cytokines and Inflammation : abstracts GTCbio’s 5- th conference, Breckenridge, Colorado, January 29-30 2007. - Breckenridge, 2007. - P55
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
CRITICAL STATES -- CYTOCINEMIA -- CELLULAR IMMUNITY

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3.
Инвентарный номер: нет.
   
   Z 86


    Zotova, N. V.
    Systemic inflammation: methodological approaches to identification of the common pathological process / N. V. Zotova, V. A. Chereshnev, E. Yu. Gusev // PLOS One. - 2016. - Vol. 11, № 5. - P. e0155138
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
MULTI-SYNDROME -- PATHOLOGICAL PROCESS
Аннотация: We defined Systemic inflammation (SI) as a “typical, multi-syndrome, phase-specific pathological process, developing from systemic damage and characterized by the total inflammatory reactivity of endotheliocytes, plasma and blood cell factors, connective tissue and, at the final stage, by microcirculatory disorders in vital organs and tissues.” The goal of the work: to determine methodological approaches and particular methodical solutions for the problem of identification of SI as a common pathological process. SI can be defined by the presence in plasma of systemic proinflammatory cell stress products—cytokines and other inflammatory mediators, and also by the complexity of other processes signs. We have developed 2 scales: 1) The Reactivity Level scale (RL)–from 0 to 5 points: 0-normal level; RL-5 confirms systemic nature of inflammatory mediator release, and RL- 2–4 defines different degrees of event probability. 2) The SI scale, considering additional criteria along with RL, addresses more integral criteria of SI: the presence of ≥ 5 points according to the SI scale proves the high probability of SI developing. To calculate the RL scale, concentrations of 4 cytokines (IL-6, IL-8, IL-10, TNF-α) and C-reactive protein in plasma were examined. Additional criteria of the SI scale were the following: D-dimers>500ng/ml, cortisol>1380 or <100nmol/l, troponin I≥0.2ng/ml and/or myoglobin≥800ng/ml. 422 patients were included in the study with different septic (n-207) and aseptic (n-215) pathologies. In 190 cases (of 422) there were signs of SI (lethality 38.4%, n-73). In only 5 of 78 cases, lethality was not confirmed by the presence of SI. SI was registered in 100% of cases with septic shock (n-31). There were not significant differences between AU-ROC of CR, SI scale and SOFA to predict death in patients with sepsis and trauma.

\\\\expert2\\NBO\\PLoS ONE\\2016, v.11, p. e0155138pdf.pdf
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4.
Инвентарный номер: нет.
   
   I-55


   
    Immunopathophysiology of systemic inflammation / V. A. Chereshnev, E. Gusev , N. V. Zotova, M. V. Chereshneva // 13 th World Congress on Inflammation : program and abstract book. - London, 2017. - P52-53
ББК 54
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ

\\\\Expert2\\NBO\\статьи из сборников\\13 th WCI 2017 Abstract Book С.52-53.pdf
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