Центральная Научная Библиотека УрО РАН

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   A 10


    A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections. / G. Bocharov, R. Züst, L. Cervantes-Barragan [et al.] // PLOS pathogens. - 2010. - Vol. 6, № 7. - P1-15 : рис., a-табл. - Bibliogr. : p. 14-15 (52 ref.)

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRUS AGENT -- DENDRITIC CELL -- ALLERGY AND IMMUNOLOGY
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs

\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
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    Влияние "профеталя"® на морфологические изменения в селезенке при экспериментальном проникающем ранении глаза / В. А. Черешнев, Ю. И. Шилов, М. В. Черешнева, Т. В. Гаврилова // Морфологические ведомости. - 2009. - Т. 1, № 1/2. - С. 68-70
Кл.слова (ненормированные):
ПРОФЕТАЛЬ -- МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ -- СЕЛЕЗЕНКА
Аннотация: The study of the effect of immune modulator profetal (alpha% fetoprotein as an active substance) on morphological changes in spleen under the experimental eye penetrating injury has been made in 46 Wistar male rats. Histological and morphometric methods were used in this work. It was determined that the use of profetal led to an increase in size of spleen B cell%depended areas and number of macrophages

\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Морфологические ведомости\\2009. Т.1, №12. С. 68-70.pdf
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   S 98


    System of hemopoiesis and morphogenesis [Electronic resource] / B. G. Yushkov, V. A. Chereshnev, N. V. Tyumentseva, O. S. Artashyan, A. I. Kuz'min // Bulletin of experimental biology and medicine. - 2005. - Vol.140, №5. - P627-630. - Bibliogr. : p. 630 (6 ref.)

ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
AUTOPROSTHESES -- HEMOPOIESIS -- MORPHOGENETIC FUNCTION
Аннотация: Method of transplantation of hemopoietic cells is proposed for acceleration of recovery of damaged tissue structures. The morphogenetic effect of transplantation depended on the state of damaged tissue and was determined by not only hemopoietic stem cells, but also lymphocytes, macrophages, and mast cells

\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2005, v.140, N 5, p. 627.pdf
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   T 44


    The blood system and the organism adaptation to extreme factor / V. A. Chereshnev, B. G. Lushkov, M. N. Sumin, N. V. Tyumentseva, I. S. Khramtsova, I. G. Danilova // Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk . - 2004. - Vol.90, №10. - P1193-1202

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
HEMOGLOBIN -- HEMATOPOIESIS -- LEUKOCYTE
Аннотация: The formation of blood system adoptive reaction in many cases is defined by the type of action and the condition of hemopoietic inductive microenvironment: hemodynamics of hemopoietic tissue, functional conditions of bone marrow macrophages, mast cells and glycosaminoglycans content. The shift in hemodlobin fraction occurs in extreme conditions requiring an increased gas transport by the blood. In case of tissue lesion, lymphocytes stimulate their regeneration. Morphogenetic function of lymphoid cells may be alerted by immunomodulators. Blood cells participate in angiogenesis, and this property may be used for vessel grafts production

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   В 58


    Влияние «Профеталя» на морфологические изменения в селезенке при экспериментальном проникающем ранении глаза / В. А. Черешнев, Ю. И. Шилов, М. В. Черешнева [и др.] // Морфологические ведомости. - 2009. - Т. 1, № 1-2. - С. 68-70. - Библиогр.: с. 70 (15 назв.)

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ПРОФЕТАЛЬ -- ПРОНИКАЮЩЕЕ РАНЕНИЕ ГЛАЗА -- СЕЛЕЗЕНКА
Аннотация: The study of the effect of immune modulator profetal (alpha% fetoprotein as an active substance) on morphological changes in spleen under the experimental eye penetrating injury has been made in 46 Wistar male rats. Histological and morphometric methods were used in this work. It was determined that the use of profetal led to an increase in size of spleen B cell%depended areas and number of macrophages

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   S 96

    Sviridova, T. G.
    Homoserine lactones and resorcinolic lipids inhibit In vitro pro-and anti-inflammatory cytokine production / T. G. Sviridova, D. G. Deryabin, V. A. Chereshnev // Research Journal of Immunology. - 2013. - Vol. 6, № 1. - P7-16. - Библиогр.: с. 14-16 (27 ref.)

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
HOMOSERINE LACTONES -- RESORCINOLIC LIPIDS -- IMMUNE SYSTEM
Аннотация: Homoserine Lactones (HSLs) and Resorcinolic Lipids (RLs) originating from microbes and plants influence immune system, however, it is currently unclear whether HSLs and RLs are activators or suppressors of the cytokine network, especially in humans. A study has been carried out to investigate the effects of pure, synthetic HSLs and RLs with different chain lengths on pro-and anti-inflammatory cytokines produced by human blood monocyte cultures. Human monocytes (macrophages and lymphocytes) were collected from leukocyte-rich plasma, separated on a double density gradient, pre-treated with HSLs or Rls and then were inducted with standard either lipopolysaccharide or phytohemagglutinin stimulus. Quantitative assays for pro-and anti-inflammatory cytokines in the monocyte culture supernatants were performed using enzyme immunoassay kits for the quantitative determination of IL-1β, IL-2, IL-4, IL-10, TNF-α and IF-γ. We observed differences in cytokine production according to HSL and RL pre-treatment, increasing in the following order: IL-1β→IL-2≈IL-10≈TNF-α→IL-4→IF-γ. HSLs have been shown more pronounced inhibitory effects than Rls and long-chained homologs were more active than short-chained ones. Our study suggests that some small molecules originating from microbes and plants play an important role in cytokine network regulation and the immunomodulatory effect of HSLs and RLs may obstruct host defenses and affect inflammatory processes

\\\\expert2\\NBO\\Research Journal of Immunology\\2013. V. 6, N 1. P. 7-16.pdf
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   В 58


    Влияние МП-3 на продукцию активных форм кислорода, IL-1β И TNF-α перитонеальными макрофагами мышей при проникающем ранении глаза / Т. В. Гаврилова, Л. С. Журавлева, М. В. Черешнева [и др.] // Российский иммунологический журнал. - 2017. - Т. 11, № 2. - С. 271-273

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ПРОНИКАЮЩЕЕ РАНЕНИЕ ГЛАЗА -- МАКРОФАГИ -- МИЕЛОПЕПТИДЫ -- АКТИВНЫЕ ФОРМЫ КИСЛОРОДА -- ЦИТОКИНЫ -- PENETRATING EYE INJURY -- MACROPHAGES -- MYELOPEPTIDES -- REACTIVE OXYGEN SPECIES -- CYTOKINES
Аннотация: Таким образом, миелопептид МП-3 оказывает модулирующее действие на функции перитонеальных макрофагов, отменяя индуцированное проникающим ранением глаза усиление продукции IL-1β.

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Российский иммунологический журнал\\2017 Т.11 № 2 С.271-273 .pdf
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   R 35


    Regulation of the peritoneal macrophage functional activity by the MP-5 and MP-6 myelopeptides under stress / S. V. Gein, T. V. Gavrilova, O. N. Gein [et al.] // Doklady Biological Sciences. - 2017. - Vol. 475, № 1. - P154-156

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
PEPTIDES -- MACROPHAGES -- ACTIVE OXYGEN
Аннотация: In mice, two-hour immobilization stress inhibited zymosan-induced production by macrophages of the oxygen radicals and cytokine IL-1[beta]. After myelopeptides MP-5 and MP-6 were administered into mice, the stress-induced inhibition of the reactive oxygen species (ROS) and IL-1[beta] was abrogated. MP-5 peptide stimulated spontaneous ROS production by macrophages and reduced IL-10 production under stress. Thus, under in vivo conditions and under stress, the effect of MP-5 and MP-6 myelopeptides modulates the peritoneal macrophage activity.

\\\\Expert2\\NBO\\Doklady Biological Sciences\\2017. - Vol. 475, № 1. - P. 154.pdf
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    Prognostic and immunotherapeutic significance of tumorinfiltrating M2 macrophages in muscle-invasive bladder cancer / G. Liu, M. Bolkov, K. Shinwari [et al.] // AIP Conference Proceedings. - 2022. - Vol. 2390, № 1. - P030048
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ

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