I-57 In vitro immunomodulating activity of biosurfactant glycolipid complex from Rhodococcus ruber / M. S. Kuyukina, I. B. Ivshina, S. V. Gein, V. A. Chereshnev // Herald of the Russian Academy of Sciences. - 2007. - Vol. 77, № 5. - P326-330 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ACTINOBACTERIA -- RHODOCOCCUS RUBER -- BIOSURFACTANT Аннотация: The biosurfactant glycolipid complex synthesized by Rhodococcus ruber actinobacteria is not toxic and exhibits no appreciable effect on proliferative activity of peripheral blood leukocytes. In the monocyte fraction, the biosurfactant activates the production of IL-1 beta and TNF-alpha cytokines without modifying the production of IL-6. In the mononuclear fraction, the glycolipid biosurfactant exhibited no effects on the production of IL-1 beta, TNF-alpha, and IL-6. These results indicate good prospects for further studies of immunomodulating and antitumor activities of biosurfactant drug \\\\Expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2007, v.144, N 3, p. 326.pdf |
T 84 Trehalolipid biosurfactants from nonpathogenic Rhodococcus actinobacteria with diverse immunomodulatory activities / M. S. Kuyukina, I. B. Ivshina, T. A. Baeva [et al.] // New Biotechnology. - 2015. - V. 32., № 6. - P559-568. - Bibliogr. : p. 566-568 (82 ref.) Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): IMMUNOLOGICAL ACTIVITIES -- TREHALOLIPIDS -- RHODOCOCCUS RUBBER Аннотация: Actinobacteria of the genus Rhodococcus produce trehalolipid biosurfactants with versatile biochemical properties and low toxicity. In recent years, these biosurfactants are increasingly studied as possible biomedical agents with expressed immunological activities. Applications of trehalolipids from Rhodococcus, predominantly cell-bound, in biomedicine are also attractive because their cost drawback could be less significant for high-value products. The review summarizes recent findings in immunomodulatory activities of trehalolipid biosurfactants from nonpathogenic Rhodococcus and related actinobacteria and compares their biomedical potential with well-known immunomodifying properties of trehalose dimycolates from Mycobacterium tuberculosis. Molecular mechanisms of trehalolipid interactions with immunocompetent cells are also discussed. \\\\expert2\\nbo\\New Biotechnology\\2015. V. 32. N 6. P. 559-568.pdf |