S 54 Shmagel, K. V. Molecular bases of immune complex pathology [Electronic resource] / K. V. Shmagel, V. A. Chereshnev // Biochemistry. - 2009. - Vol. 74, № 5. - P469-479. - Bibliogr. : p. 477-479 (126 ref.) Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): IMMUNE COMPLEXES -- COMPLEMENT -- CR1 RECEPTORS Аннотация: The binding of antigens with antibodies forms immune complexes in the body. Usually these complexes are eliminated by the system of mononuclear phagocytes without development of pathological changes. This review highlights principal mechanisms responsible for safe removal of immune complexes in primates and humans. Special attention is given to diseases known as "immune complex diseases", when antigen-antibody complexes induce inflammatory reactions. The review considers key experimental works that significantly contributed to current knowledge of etiology and pathogenesis of type III hypersensitivity. Some factors of the development of immune complex syndrome such as level of humoral immune response to antigen, isotype and affinity of forming antibodies, the amount of immune complexes, and the consequences of their interaction with the complement system and Fc-receptors are analyzed based on the molecular mechanisms involved. The review contains a retrospective analysis of the most significant scientific achievements in immune complex pathology investigation within the last 100 years \\\\expert2\\NBO\\Biochemistry\\2009, v.74, p. 469-479.pdf |
T 44 The effect of polyoxidonium on immune response and morphological parameters of inflammation after experimental penetrating eye injury / V. A. Chereshnev, M. V. Chereshneva, Yu. I. Shilov [et al.] // Doklady Biological Sciences. - 2012. - Vol. 443, № 1. - P75-77. - Bibliogr. : p. 77 (10 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): AZOXIMER BROMIDE -- DEXAMETHASONE -- HETEROPHILE ANTIGEN \\\\expert2\\NBO\\Doklady Biological Sciences\\2012. V. 443, N 1. P. 75-77.pdf |
F 33 Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number / G. Bocharov, J. B. Quiel, T. B. Luzyanina [и др.] // Proceedings of the National Academy of Sciences of the United States of America. - 2011. - Vol. 108, № 8. - С. 3318-3323 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): PARAMETER ESTIMATION -- TIME DELAY -- BROXURIDINE Аннотация: The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain to be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) and factor of expansion (FE), with a slope of ∼-0.5 over a range of 3-30,000 precursors per mouse. The results suggested inhibition of precursor expansion either by competition for specific antigen-presenting cells or by the action of other antigen-specific cells in the same microenvironment as the most likely explanation. Several molecular mechanisms potentially accounting for such inhibition were examined and rejected. Here we adopt a previously proposed concept, "feedback-regulated balance of growth and differentiation," and show that it can explain the observed findings. We assume that the most differentiated effectors (or memory cells) limit the growth of less differentiated effectors, locally, by increasing the rate of differentiation of the latter cells in a dose-dependent manner. Consequently, expansion is blocked and reversed after a delay that depends on initial PN, accounting for the dependence of the peak of the response on that number. We present a parsimonious mathematical model capable of reproducing immunization response kinetics. Model definition is achieved in part by requiring consistency with available BrdU-labeling and carboxyfluorescein diacetate succinimidyl ester (CFSE)-dilution data. The calibrated model correctly predicts FE as a function of PN. We conclude that feedback-regulated balance of growth and differentiation, although awaiting definite experimental characterization of the hypothetical cells and molecules involved in regulation, can explain the kinetics of CD4 T-cell responses to antigenic stimulation \\\\expert2\\nbo\\PNAS\\2011. - Vol.108, №8. - С. 3318-3323.pdf |
T 44 The use of profetal for correction of the stress-and trauma-induced changes in the immune response against a xenogeneic antigen in rats with a penetrating wound of the eye / V. A. Chereshnev, M. V. Chereshneva, R. R. Faizrakhmanov, T. V. Gavrilova // Doklady Biological Sciences. - 2007. - Vol. 417, № 1. - С. 420-422 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): ALPHA FETOPROTEIN -- PRODUCING CELL -- ERYTHROCYTE \\\\expert2\\NBO\\Doklady Biological Sciences\\2007. V. 417, N 1.P. 420.pdf |
M 99 Myelopeptides in treatment for stress- and injury-induced changes in the immune response to a heterologous thymus-dependent antigen in rats with penetrating eye wounds [Electronic resource] / T. V. Gavrilova, N. L. Berkasova, Yu. I. Shilov, M. V. Chereshneva, V. A. Chereshnev // Doklady Biological Sciences. - 2007. - Vol. 412, № 1. - P8-10 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): ANTIGEN -- MYELOPEPTIDES -- OLIGOPEPTIDE \\\\expert2\\nbo\\Doklady Biological Sciences\\2007. V. 412, N 1.P. 8-10.pdf |
E 71 Erratum: ''Myelopeptides in treatment for stress-and injury-induced changes in the immune response to a heterologous thymus-dependent antigen in rats with penetrating eye wounds'' [Doklady Biological Sciences (2007) 412 (8-10)] / T. V. Gavrilova, N. L. Berkasova, Yu. I. Shilov , V. A. Chereshnev, M. V. Chereshneva // Doklady Biological Sciences. - 2007. - Vol. 414, № 1. - P251 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): MYELOPEPTIDES -- IMMUNE RESPONSE -- ANTIGEN |
N 52 New capacities of the phagocytic test used in pediatric phthisiology / L. P. Sanakoeva, A. D. Koriukina, V. A. Chereshnev, V. A. Aksenova // Probl Tuberk Bolezn Legk . - 2004. - №6. - P42-48 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): BCG VACCINE -- LUNG TUBERCULOSIS -- PHAGOCYTOSIS Аннотация: The paper presents the results of a study of the phagocytic activity of leukocytes (PAL) in 98 healthy children, vaccinated with BCG, in different periods after immunization and in 68 children with tuberculous infection (39 children with tuberculosis and 29 Mycobacterium tuberculosis-infected children). An improved procedure for studying PAL was used, in which sheep erythrocytes of two types ("antigenic" and those with a complex of antigen + antibody + antigen), which may differentiate the phase of bacteremia and immune synthesis, were used as an object for phagocytes. In the limited number of vaccinated children, bacteremia were detectable up to 9 months; the phase of immune synthesis continued in most children up to 3 years. The study has demonstrated that a complex of phagocytic tests may be used for the early diagnosis of tuberculous infection, for the evaluation of a tuberculous process and antituberculous immunity |
C 51 Chereshnev, V. A. Changes in specific reaction of erythrocytes to the antigen after administration of methylene blue and sodium azide / V. A. Chereshnev, V. P. Rochev // Gigiena i sanitariia . - 1992. - № 5-6. - P. 64-65 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): BACTERIAL ANTIGEN -- METHYLENE BLUE -- SODIUM AZIDE |
Checking gene expression profile associated with IRF7 and UNC93B deficient patient peripheral blood mononuclear cells infected with pH1N1 influenza virus / K. Shinwari, G. Liu, M. A. Bolkov [et al.] // AIP Conference Proceedings. - 2022. - Vol. 2390, № 1. - Ст. 030089 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): VIRUSES -- MICROARRAYS -- GENOMICS Аннотация: An innate immune defect is a defect in the innate immune response that reduces the response to infection, this can occurs in genes important for activation regulation and proliferation of the innate immune cells or pathways important for the function of innate immunity. The purpose of this study was to identify novel biomarkers of interferon Receptor 7 through bioinformatics analysis and elucidate the possible molecular mechanism. The GSE 66486 datasets containing microarray data from IRF7 and UNC93B patients and healthy controls were downloaded from the GEO database and analyzed by the GEO2R web tool to obtain different expressed genes (DEGs). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, protein-protein interaction (PPI), and Biological Networks Gene Oncology tool (BiNGO) were then performed to elucidate the molecular mechanism of IRF7. A total of 490 DEGs were identified, of which 14 were hub genes, and involved in ribosome biogenesis, rRNA processing, gene expression, mRNA processing, nuclear lumen, intracellular non-membrane-bounded organelle, nucleoplasm, small-subunit processome, antigen processing and presentation pathway, and ribosome biogenesis in eukaryotes. Antigen processing and presentation pathway, and ribosome biogenesis in eukaryotes possibly form the basis of IRF7 or UNC93B disorders, while our study provides a list of genes and pathways that are disrupted in IRF7/UNC93B, which has the potential to be used in the clinic for diagnosis and targeted therapy of such disorders in future. |