H 91 Human immunodeficiency virus infection: From biological observations to mechanistic mathematical modelling / G. Bocharov, V. A. Chereshnev, I. C. Gainova [et al.] // Mathematical modelling of natural phenomena. - 2012. - Vol. 7, № 5. - P78-104. - Bibliogr. : p. 93-104 (275 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): HOST-PATHOGEN INTERACTION -- IMMUNE SYSTEM -- HUMAN IMMUNODEFICIENCY Аннотация: HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic mechanisms are manifold and mediated through a range of positive and negative feedback regulations of immune and physiological processes engaged in virus-host interactions. The fundamental questions towards understanding the pathogenesis of HIV infection are now shifting to 'dynamic' categories: (i) why is the HIV-immune response equilibrium finally disrupted? (ii) can one modify the dynamic equilibrium for host benefit? (iii) can one predict the outcome of a system perturbation via antiviral drugs or drugs modulating the host immune response dynamics? Answering these questions requires a major interdisciplinary effort, and in particular, the development of novel mathematical approaches for a coherent quantitative description and prediction of intra-patient HIV evolution, the immunological responses to HIV infection, and the systems level homeostatic regulation of specific effector and regulatory lymphocyte populations in correlation with disease status. Here we summarized fundamental biological features of HIV infection and current mathematical modelling attempts to understand HIV pathogenesis \\\\expert2\\NBO\\Mathematical Modelling and Natural Phenomena\\2012. V. 7, N 5. P. 78-104.pdf |
S 43 Secondary immunodeficiency induced by unfavourable environmental conditions / V. A. Chereshnev, N. N. Kevorkov, B. A. Bachmetyev, M. B. Rayev, Ju. I. Shilov, S. V. Shirshev // XVth International Congress of Allergology and Clinical Immunology & Annual Meeting of the European Academy of Allergology and Clinical Immunology : аbstracts. - Stockholm : Hogrefe & Huber Publishers, 1994. - № 2. - P. 195 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): IMMUNODEFICIENCY |
Novel high-risk missense mutations identification in FAT4 gene causing Hennekam syndrome and Van Maldergem syndrome 2 through molecular dynamics simulation / K. Shinwari, H. Rehman, N. Xiao [et al.] // Informatics in Medicine Unlocked. - 2023. - Vol. 37. - Ст. 101160 (14 pp.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): HENNEKAM SYNDROME -- PRIMARY IMMUNODEFICIENCY -- FAT4 MISSENSE SNP |
M 39 Mathematical modelling of the within-host HIV quasispecies dynamics in response to antiviral treatment [Text] / G. A. Bocharov, I. S. Telatnikov, V. A. Chereshnev [et al.] // Russian Journal of Numerical Analysis and Mathematical Modelling. - 2015. - Vol. 30, № 3. - P157-170 : il. - Bibliogr. : p. 169-170 (29 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): MATHEMATICAL MODEL -- HUMAN IMMUNODEFICIENCY VIRUS -- GENETIC ALGORITHM -- QUASISPECIES -- VIRUS INFECTION Аннотация: The aim of this work is the construction, calibration, and comparative analysis of mathematical models of the evolution of the human immunodeficiency virus (HIV) in the course of infection when the models are based on deterministic principles of the quasispecies theory (Eigen-Schuster) and on stochastic approaches of genetic algorithms (Holland). The models take into account the replication of viral genomes and selection of descendants according to their fitness, point mutations, multi-infection of target cells and recombination of genomes at the stage of formation of proviral DNA. The processes of diversification of the virus population under the action of the antiviral drug azidothymidine (AZT) that blocks reverse transcription of the virus are simulated. A four-letter alphabet is used in the stochasticmodel for description of nucleotide sequences. The parameters of the model are estimated using original data on the degree of adaptation of the HIV mutants that are partly or completely resistant to this drug. The influence of parameters of infection on the characteristics of viral mutants population diversity is studied \\\\expert2\\nbo\\Russian Journal of Numerical Anal. and Math. Modelling\\2015. V.30, N. 3. P. 157-170.pdf |
S 54 Shilov, S. Yu. Interdependence of immunomodulatory effects of hydrocortisone and of the immune response / S. Yu. Shilov, Y. I. Shilov, V. A. Chereshnev // Environmental Polution : VI International Conference, Perm-Kazan-Perm, September 20-25, 2005 : abstracts. - Perm, 2005. - P204 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): IMMUNODEFICIENCY |
Newborn Screening through TREC, TREC/KREC system for Primary Immunodeficiency with limitation of TREC/KREC. Comprehensive review / K. Shinwari, M. A. Bolkov, I. A. Tuzankina, V. A. Chereshnev // Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry. - 2021. - Vol. 20. - P132-149 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): PRIMARY iMMUNODEFICIENCY -- T-CELL LYMPHOPENIA Аннотация: Newborn screening (NBS) by quantifying T cell receptor excision circles (TRECs) and Kappa receptor excision circles in neonatal dried blood spots (DBS) enables early diagnosis of different types of primary immune deficiencies. Global newborn screening for PID, using an assay to detect T-cell receptor excision circles (TREC) in dried blood spots (DBS), is now being performed in all states in the United States. In this review, we discuss the development and outcomes of TREC, TREC/KREC combines screening, and continued challenges to implementation. \\\\nas3\\Nbo\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry. - 2021. - Vol. 20. - P. 132-149 |