M 99 Myelopeptides regulate the microbicidic and secretory activities of Innate immunity effectors / V. A. Chereshnev, S. V. Gein, L. S. Mazunina [et al.] // Doklady biochemistry and biophysics. - 2011. - Vol. 436, № 1. - P53-55. - Bibliogr. : p. 55 (9 ref.) Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): MYELOPEPTIDES -- MICROBICIDIC -- INNATE iMMUNITY \\\\expert2\\NBO\\Doklady Biological Sciences\\2011. V. 436, N 1.P. 53-55.pdf |
Modulation of Cytokine secretion and oxidative metabolism of innate immune effectors by Rhodococcus Biosurfactant / V. A. Chereshnev, S. V. Gein, T. A. Baeva [et al.] // Bulletin of experimental biology and medicine. - 2010. - Vol. 149, № 6. - P734-738 Кл.слова (ненормированные): RHODOCOCCUS RUBBEr -- GLYCOLIPID BIOSURFACTANT -- INTERLEUKIN-10 Аннотация: The glycolipid biosurfactant complex from Rhodococcus ruber IEGM 231 had a stimulatory effect on the production of IL-12, IL-18, and reactive oxygen species by cells of the innate immunity. This effect depended on the composition of cell cultures and presence of LPS. It was primarily observed in non-stimulated cultures. The glycolipid biosurfactant complex had little effect on IL-10 secretion by monocytes and mononuclear cells \\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2010, v.149, N 6, p. 734-738.pdf |
I-57 In vitro immunomodulating activity of biosurfactant glycolipid complex from Rhodococcus ruber / M. S. Kuyukina, I. B. Ivshina, S. V. Gein, V. A. Chereshnev // Herald of the Russian Academy of Sciences. - 2007. - Vol. 77, № 5. - P326-330 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ACTINOBACTERIA -- RHODOCOCCUS RUBER -- BIOSURFACTANT Аннотация: The biosurfactant glycolipid complex synthesized by Rhodococcus ruber actinobacteria is not toxic and exhibits no appreciable effect on proliferative activity of peripheral blood leukocytes. In the monocyte fraction, the biosurfactant activates the production of IL-1 beta and TNF-alpha cytokines without modifying the production of IL-6. In the mononuclear fraction, the glycolipid biosurfactant exhibited no effects on the production of IL-1 beta, TNF-alpha, and IL-6. These results indicate good prospects for further studies of immunomodulating and antitumor activities of biosurfactant drug \\\\Expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2007, v.144, N 3, p. 326.pdf |
E 27 Effect of myelopeptides on reactive oxygen species generation and IL-1beta and TNF-alpha production by peripheral blood cells / // Patologicheskaia fiziologiia i èksperimental'naia terapiia. - 2012. - № 1. - P19-22 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): IL1B PROTEIN -- HUMAN -- IMMUNOLOGICAL ADJUVANT Аннотация: Myelopeptides MP-3, MP-5, and MP-6 were found to suppress zymosan-induced production of reactive oxygen species by leukocytes both under one-way introduction and under pretreatment. All of myelopeptides under examination in case of one-way introduction in cultures with zymosan demonstrated a decrease in zymosan-stimulated (1500 mkg/ml) production of IL-1beta, and activation of spontaneous production of this cytokine by whole blood cells. TNF-alpha production under myelopeptide effect was lowered in cultures with 150 mkg/ml zymosan. Under pretreatment myelopeptides did not render effect on IL-1beta and TNF-alpha production, with the exception of single stimulating effect of MP-5 on IL-1beta level in spontaneous cultures. Using comparative analysis the difference in direction and expressivity of effects of various myelopeptides was not revealed that suggests the existence of common mechanism of action in this group of peptide bioregulators. |
I-57 In vitro cytokine stimulation assay for glycolipid biosurfactant from Rhodococcus ruber: Role of monocyte adhesion / S. V. Gein, M. S. Kuyukina, I. B. Ivshina, V. A. Chereshnev // Cytotechnology. - 2011. - Vol. 63, № 6. - P559-566. - Bibliogr. : p. 565-566 (23 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): CYTOKINE-STIMULATING ACTIVITY -- GLYCOLIPID BIOSURFACTANT -- MONOCYTE ADHESION Аннотация: Glycolipid biosurfactant (GLB) from Rhodococcus ruber IEGM 231 was found to stimulate tumor necrosis factor-α (TNF-α), interleukin (IL) -1β and IL-6 production when applied as an ultrasonic emulsion to the adherent human peripheral blood monocyte culture. However, a lack of cytokine-stimulating activity was registered with the GLB applied as a hydrophobic film coating in 24-well culture plates, indicating that it may have been due to its inhibitory effect on monocyte adhesion. The mode of GLB application may therefore play an important role in in vitro assay of immunostimulatory activity of this compound as well as other bacterial glycolipids. Additionally, GLB from R. ruber displayed no cytotoxicity against human lymphocytes and therefore could be proposed as a potential immunomodulating and antitumor ag \\\\expert2\\NBO\\Cytotechnology\\2011. V. 63, N 6. P. 559-566.pdf |
C 51 Chereshnev, V. A. Beta-endorphin as the endogenous regulator of immune processes / V. A. Chereshnev, S. V. Gein // Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova. - 2009. - Vol. 95, № 12. - P1279-1290 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): BETA ENDORPHIN -- OPIATE RECEPTOR -- ADAPTIVE IMMUNITY Аннотация: Endogenous opioid peptides represent the group of bioregulatory factors possessing a wide range of biologically active effects. One of most essential functions of endogenous opioids appears to be the realization of cellular interaction between nervous and immune systems. Beta-endorphin is a peptide hormone that is the most active and multi-functional representative of the opioid peptide family. This review summarizes current observations on the nature ofbeta-endorphin, its production by the immune system cells, opiate receptor structure and expression, as well as the peptide effect on the processes of cellular activation, proliferation, and differentiation in innate and adaptive immunity |
G 33 Gein, S. V. Effect of myelopeptides on IFN-γ and IL-4 production by peripheral blood lymphocytes [Electronic resource] / S. V. Gein, T. V. Gavrilova, V. A. Chereshnev // Doklady Biological Sciences. - 2007. - Vol. 413, № 1. - P161-163 : рис., a-табл. Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): MYELOPEPTIDES -- IL-4 PRODUCTION -- LYMPHOCYTES \\\\expert2\\NBO\\Doklady Biological Sciences\\2007. V. 413, N 1.P. 161.pdf |
T 44 The role of monocytes in the effects of β-endorphin and selective agonists of μ-and δ-opiate receptors on the proliferative activity of peripheral blood lymphocytes / S. V. Gein, T. A. Baeva, O. N. Gein, V. A. Chereshnev // Human Physiology. - 2006. - Vol. 32, № 3. - P346-350 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): MONOCYTES -- BETA ENDORPHIN -- BLOOD LYMPHOCYTES Аннотация: The effects of β-endorphin under the conditions of naloxone hydrochloride blockade of opiate receptors, as well as the effects of the selective agonists of μ-and δ-receptors DAGO and DADLE and the effects of melanocyte-potentiating factor (MPF), on the in vitro proliferative response of lymphocytes were studied. The dose-effect dependence indicated stimulating effects of β-endorphin, DAGO, and DADLE on the proliferative response in the presence of phytohemagglutinin (PHA). The tetrapeptide MPF, which is the C-terminal sequence of β-endorphin, had almost no effect on the proliferative activity of lymphocytes. β-Endorphin, naloxone, and the μ-and δ-receptor selective agonists enhanced the proliferative response of lymphocytes in an unfractionated cell culture, whereas β-endorphin, naloxone, and DAGO suppressed the proliferative activity of lymphocytes in the mononuclear fraction purified of monocytes. In both cases, the naloxone blockade of opiate receptors enhanced rather than eliminated the β-endorphin e \\\\expert2\\nbo\\Human Physiology\\2006. V. 32, N 3. P. 346-350.pdf |
I-55 Immunomodulation of injury and stress-induced immunological disorders in penetrating wound of the eye / M. V. Chereshneva, Yu. I. Shilov , T. V. Gavrilova, S. V. Gein, V. A. Chereshnev // Vestnik oftalmologii. - 2006. - Vol. 122, № 2. - P42-46 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): IMMUNOSUPPRESSIVE AGENT -- ANIMAL -- CELLULAR IMMUNITY |
M 45 Mechanism underlying the effect of myelopeptides on lymphocyte proliferation in vitro [Electronic resource] / T. V. Gavrilova, S. V. Gein, T. A. Pogudina, V. A. Chereshnev // Bulletin of experimental biology and medicine. - 2005. - Vol. 140, № 1. - P74-76. - Bibliogr. : p. 76 (7 ref.) Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): LYMPHOCYTE BLAST TRANSFORMATION -- MONOCYTES -- MYELOPEPTIDES Аннотация: We studied the role of monocytes in the effect of myelopid and myelopeptides MP-1, MP-3, MP-5, and MP-6 on functional activity of peripheral blood lymphocytes in the reaction of blast transformation. Myelopeptides MP-1, MP-3, and MP-6 suppressed blast transformation of lymphocytes. The effect depended on the presence of monocytes in a cell culture \\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2005, v.140, N 1, p. 74.pdf |
I-60 Influence of myelopid, myelopeptides MP-5 and MP-6 on lymphocyte proliferative activity / T. V. Gavrilova, S. V. Gein, T. A. Pogudina, V. A. Chereshnev // Doklady Akademii Nauk . - 2004. - Vol.398, №4. - P560-562 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): CELL CULTURE -- COMPOSITION EFFECTS -- LYMPHOCYTES Аннотация: The effect on activity of peripheral blood lymphocytes upon blast-transformation reaction induced by phytohemagglutinin (PGA) in different concentrations was investigated. For the first time the different-directed activity of MP-6 tetrapeptide in respect to stimulated PGA and non-stimulated peripheral blood lymphocytes is shown. Dependence of MP-6 effects on its own concentration as well as on the mitogen concentration in the cell culture is demonstrated. Myelopid and MP-5 didn't affect the lymphocyte functional activity |
E 27 Effects of myelopidum and myelopeptides MP-5 and MP-6 on lymphocyte proliferative response / T. V. Gavrilova, S. V. Gein, T. A. Pogudina, V. A. Chereshnev // Doklady Biological Sciences. - 2004. - Vol. 398. - P360-362 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): MYELOPEPTIDES -- MYELOPIDUM -- OLIGOPEPTIDE \\\\expert2\\NBO\\Doklady Biological Sciences\\2004. V. 398, P. 360-362.pdf |
I-57 In vitro immunomodulating properties of biosurfactant glicolipid complex in the rhodococcus rubber. The role of monocyte and cell adhesion / S. V. Gein, M. S. Kuyukina, I. B. Ivshina [et al.] // Environmental pollution, adaptation, immunity : abstracts VII International Conference. - Perm, 2008. - P147 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): IMMUNOMODULATING PROPERTIES -- GLICOLIPID COMPLEX -- MONOCYTES |
G 33 Gein, S. V. Effect of beta-endorphin and DAGO, a selective agonist of mu-opioid receptors, on the proliferative activity of lymphocytes / S. V. Gein, T. A. Simonenko, V. A. Chereshnev // Doklady Biological Sciences. - 2003. - Т. 391, № 1-6. - С. 289-291. - Bibliogr. : p. 291 (14 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): DAGO -- LYMPHOCYTES -- BETA-Endorphin \\\\expert2\\nbo\\Doklady Biological Sciences\\2003. V. 391, P. 289-291.pdf |
S 54 Shilov, Y. I. Influence of Blockade of β-Adrenoreceptors and Acute Stress on Antibody Formation, Delayed Type of Hypersensitivity, Phagocytic Cell Activity in Local Immune Response / Y. I. Shilov , S. V. Gein , V. A. Chereshnev // Russian Journal of Immunology. - 2001. - Vol. 6, № 3. - P. 301-308 : fig., tabl. - Bibliogr. : p. 308 (17 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): β-ADRENORECEPTORS -- ANTIBODY FORMATION -- HYPERSENSITIVITY -- PHAGOCYTIC CELL ACTIVITY \\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Российский иммунологический журнал\\2001. - Vol. 6, № 3. - P. 301-308.PDF |
E 27 Effect of myelopeptides on functions of phagocytic cells under the experimental eye penetrating wound / T. V. Gavrilova, S. V. Gein , Ju. I. Shilov, A. A. Mikhailova, V. A. Chereshnev // Scandinavian Journal of Immunology. - 2001. - Vol. 54. Suppl. 1 (July/August 2001). - P115 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): MYELOPEPTIDES -- PHAGOCYTIC CELLS |
S 54 Shilov, Ju. I. Adrenergic and cAMP-dependent regulation of mitogen-induced lymphocyte proliferative responses / Ju. I. Shilov, S. V. Gein, V. A. Chereshnev // Journal of Allergy and Clinical Immunology. - 1998. - Vol. 101, № 1, Pt. 2 (January). - P. 38 (164) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): MITOGEN-INDUCED LYMPHOCYTE |
E 27 Effect of glycolipid Rhodococcus biosurfactant on secretory activity of neutrophils in vitro / T. A. Baeva, S. V. Gein, M. S. Kuyukina [et al.] // Bulletin of experimental biology and medicine. - 2014. - Vol. 157, № 2. - P238-242. - Bibliogr. : p. 242 (15 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): GLYCOLIPID -- RHODOCOCCUS RUBER -- NEUTROPHILS Аннотация: Glycolipid biosurfactant synthesized by nonpathogenic strain Rhodococcus ruber IEGM231 modulated the production of ROS and IL-8 by peripheral blood neutrophils in spontaneous and stimulated cultures. Secretion of IL-1β и TNF-α by neutrophils in the presence of biosurfactant changed insignifi cantly \\\\expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2014, v.157, N 2, p. 238-242.pdf |
T 84 Trehalolipid biosurfactants from nonpathogenic Rhodococcus actinobacteria with diverse immunomodulatory activities / M. S. Kuyukina, I. B. Ivshina, T. A. Baeva [et al.] // New Biotechnology. - 2015. - V. 32., № 6. - P559-568. - Bibliogr. : p. 566-568 (82 ref.) Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): IMMUNOLOGICAL ACTIVITIES -- TREHALOLIPIDS -- RHODOCOCCUS RUBBER Аннотация: Actinobacteria of the genus Rhodococcus produce trehalolipid biosurfactants with versatile biochemical properties and low toxicity. In recent years, these biosurfactants are increasingly studied as possible biomedical agents with expressed immunological activities. Applications of trehalolipids from Rhodococcus, predominantly cell-bound, in biomedicine are also attractive because their cost drawback could be less significant for high-value products. The review summarizes recent findings in immunomodulatory activities of trehalolipid biosurfactants from nonpathogenic Rhodococcus and related actinobacteria and compares their biomedical potential with well-known immunomodifying properties of trehalose dimycolates from Mycobacterium tuberculosis. Molecular mechanisms of trehalolipid interactions with immunocompetent cells are also discussed. \\\\expert2\\nbo\\New Biotechnology\\2015. V. 32. N 6. P. 559-568.pdf |
G 33 Gein, S. V. Ligands of opiate receptors in regulation of lymphocyte proliferative activity in vitro / S. V. Gein , T. A. Baeva, V. A. Chereshnev // Environmental Polution : VI International Conference, Perm-Kazan-Perm, September 20-25, 2005 : abstracts. - Perm, 2005. - P213 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): LIGANDS -- LYMPHOCYTE PROLIFERATIVE |