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Каталог книг и продолжающихся изданий
Сводный каталог иностранных периодических изданий, имеющихся в библиотеках УрО РАН
Сводный каталог отечественных периодических изданий, имеющихся в библиотеках УрО РАН
Каталог диссертаций и авторефератов диссертаций УрО РАН
Каталог препринтов УрО РАН (1975 г. - )
Имидж-каталог отечественных книг (до 2010 г.)
Имидж-каталог иностранных книг (до 2010 г.)
Алфавитно-предметный указатель (АПУ) ЦНБ УрО РАН
Публикации об УрО РАН
Изобретения уральских ученых
Интеллектуальная собственность (статьи из периодики)
Нанотехнологии
Демидовские премии
Гибель династии Романовых
История Урала
Личная библиотека С. В. Вонсовского
Книжная коллекция Шубиных
Труды Института высокотемпературной электрохимии УрО РАН
Труды Института истории и археологии УрО РАН
Труды сотрудников Института горного дела УрО РАН
Труды сотрудников Института органического синтеза УрО РАН
Труды сотрудников Института теплофизики УрО РАН
Труды сотрудников Института химии твердого тела УрО РАН
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Труды сотрудников ЦНБ УрО РАН
Публикации Черешнева В.А.
Публикации Чарушина В.Н.
Каталог библиотеки ИГД УрО РАН
Каталог библиотеки ИЭРиЖ УрО РАН
Электронная энциклопедия «Дискурсология»
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1.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kanwugu O. N., Glukhareva T. V., Kovaleva E. G., Danilova I. G.
Заглавие : Natural antioxidants in diabetes treatment and management: prospects of astaxanthin
Место публикации : Critical reviews in food science and nutrition. - 2021. - Vol. 62, № 18. - С. 5005-5028
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): antioxidant--carotenoid--diabetic complication
Аннотация: Diabetes remains a major health emergency in our entire world, affecting hundreds of millions of people worldwide. In conjunction with its much-dreaded complications (e.g., nephropathy, neuropathy, retinopathy, cardiovascular diseases, etc.) it substantially reduces the quality of life, increases mortality as well as economic burden among patients. Over the years, oxidative stress and inflammation have been highlighted as key players in the development and progression of diabetes and its associated complications. Much research has been devoted, as such, to the role of antioxidants in diabetes. Astaxanthin is a powerful antioxidant found mostly in marine organisms. Over the past years, several studies have demonstrated that astaxanthin could be useful in the treatment and management of diabetes. It has been shown to protect β-cells, neurons as well as several organs including the eyes, kidney, liver, etc. against oxidative injuries experienced during diabetes. Furthermore, it improves glucose and lipid metabolism along with cardiovascular health. Its beneficial effects are exerted through multiple actions on cellular functions. Considering these and the fact that foods and natural products with biological and pharmacological activities are of much interest in the 21st-century food and drug industry, astaxanthin has a bright prospect in the management of diabetes and its complications.
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2.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Reddivari C. K. R., Devineni S. R., Yellalavenkata R. R., Chamarthi N. R., Shaik N., Nemallapudi B. R., Sravya G., Zyryanov G. V., Avula B., Badavath V. N.
Заглавие : Design, synthesis, biological evaluation and molecular docking studies of 1,4-disubstituted 1,2,3-triazoles: peg-400:h2o mediated click reaction of fluorescent organic probes under ultrasonic irradiation
Место публикации : Polycyclic aromatic compounds. - 2021. - Vol. 42, № 7. - С. 3953-3974
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): ultrasonication--123-triazole--antioxidant activity
Аннотация: The perpetual demand of medicinally significant scaffolds has prompted the synthetic chemists to identify simple and efficient routes for flawless synthesis. A PEG-400:H2O mediated highly versatile, efficacious and selective “Click reaction” of fluorescent organic Probes under ultrasonic irradiation is reported. 1,2,3-Triazole ring has also been revealed to play a crucial role in bioorthogonal methodologies, fragment-based drug design, and biomolecular mimetics. This methodology provides a rapid and efficient approach for the synthesis of 1,4-Disubstituted 1,2,3-triazoles under Copper (I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition (CuAAC) conditions in good to excellent yields in less time. This synthetic protocol has been proven to endorse easy work-up under benign reaction conditions. The green solvent system employed has been efficaciously reused several times without any loss of its activity in an aqueous medium. All the title compounds were characterized by using elemental analysis, 1HNMR, 13CNMR, FTIR, and mass spectral data. The newly synthesized compounds were biologically evaluated for their antioxidant activity. The antioxidant activity results demonstrate that all compounds showed good to excellent antioxidant activity, particularly the compounds 5d, 8 b, 8c and 8d exhibited promising radical scavenging activity. Further, photophysical properties of the compounds were accomplished using spectrofluorimeter. By this method, compounds 5c, 5e, 5f, 8a, 8 b, 8c and 8d exhibited fluorescence in the visible region. Molecular docking studies suggested the antioxidant activity of synthesized compounds due to the inhibition of neuronal nitric oxide synthase (HnNOS).
https://doi.org/10.1080/10406638.2021.1878246
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3.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Sankar P. S., Babu K. N., Padmavathi V., Sravya G., Zyryanov G. V., Sudheer K.
Заглавие : Bis(azolyl)sulfonamidoacetamides: Synthesis and bioassay
Место публикации : AIP conference proceedings. - 2022. - Vol. 2390. - Ст.020021
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): antimicrobials--bioassays--antifungal
Аннотация: Azole derivatives are valuable precursors in pharmacological arena. In fact, oxazole, thiazole and imidazole containing scaffolds display a variety of biological activities such as antitumor,1 antibacterial,2 antiviral,3 antioxidant,4,5 anti-inflammatory6 and antifungal7 activities. Azoles are also prominant molecules in various biochemical and synthetic transformations. Based on the importance of these heteroaromatics and also our interest to link the heterocycle molecules with a variety of functional groups we have synthesized a new class of bis(azolyl)sulfonamide acetamides from azolylsulfonylamines and azolylchloroacetamides in the presence of DMAP under ultrasonication and studied their antimicrobial activity. The compounds chloro substituted bis(thiazoles) (6c) and chloro substituted imidazolyl thiazoles (7c) displayed excellent antibacterial activity against B. subtilis greater than the standard drug, Chloramphenicol. Whereas 7c also showed excellent antifungal activity on A. niger higher than the standard drug, Ketoconazole.
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4.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Volobueva A. S., Zarubaev V. V., Fedorchenko T. G., Lipunova G. N., Tungusov V. N., Chupakhin O. N.
Заглавие : Antiviral properties of verdazyls and leucoverdazyls and their activity against group b enteroviruses
Место публикации : Russian journal of infection and immunity. - 2023. - Vol. 13, № 1. - С. 107-118
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): enteroviruses--enteroviral infection--coxsackievirus
Аннотация: Enteroviruses are non-enveloped viruses of Enterovirus genus, Picornaviridae family, causing a variety of human diseases: from acute respiratory and intestinal infections to more severe pathologies including poliomyelitis, encephalitis, myocarditis, pancreatitis. Currently, no approved direct-acting antiviral drugs for treatment of enterovirus infections exists, whereas vaccination is available only for prevention of poliomyelitis and enterovirus 71 infection. Therefore, it is promising to conduct a search for inhibitors of enteroviruses life cycle in drug development to treat enterovirus infections. Here, antiviral properties of stable free radicals, verdazyls, and their precursors, leucoverdazyls, were investigated. It has been shown that leucoverdazyls vs verdazyls increased the survival of permissive cell culture infected with coxsackievirus. The activity range of the lead leucoverdazyl against RNA-containing and DNA-containing human viruses (in the viral yield reduction assay) and its proposed mechanism of action (time of addition assay) was studied. The lead compound suppressed reproduction of group B enteroviruses in vitro, with modest activity against influenza A virus and no activity against herpes virus type 1 and adenovirus type 5. The maximum decrease in viral titers was observed upon its addition to infected cells during early and middle stages of the virus life cycle. Thus, we concluded that the studied compound has a pronounced inhibitory activity against group B enteroviruses not belonging to the class of capsid binder inhibitors, without virucidal properties. Previously, we described antioxidant properties of leucoverdazyls. It is known that many viral infections are accompanied by production of reactive oxygen species and oxidative stress, and some compounds with antioxidant properties exhibit antiviral potential. Targeted chemical modifications of leucoverdazyls and further studies of leucoverdazyl mechanism of action as well as in vivo animal studies are needed. However, the results obtained may be useful for future development of new antiviral drugs to treat enteroviral infections.
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5.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Elkina N. A., Shchegolkov E. V., Burgart Y. V., Agafonova N. A., Perminova A. N., Saloutin V. I., Gerasimova N. A., Evstigneeva N. P.
Заглавие : Synthesis and biological evaluation of polyfluoroalkyl-containing 4-arylhydrazinylidene-isoxazoles as antifungal agents with antioxidant activity
Место публикации : Journal of Fluorine Chemistry. - 2022. - Vol. 254. - Ст.109935
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
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6.

Вид документа : Статья из журнала
Шифр издания : Г/D 46
Автор(ы) : Gerasimova E. L., Gazizullina E. R., Borisova M. V., Igdisanova D. I., Nikiforov E. A., Moseev T. D., Varaksin M. V., Chupakhin O. N., Charushin V. N., Ivanova A. V.
Заглавие : Design and antioxidant properties of bifunctional 2H-imidazole-derived phenolic compounds-a new family of effective inhibitors for oxidative stress-associated destructive processes
Место публикации : Molecules. - 2021. - Vol. 26, № 21. - Ст.6534
ББК : Г
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): 2h-imidazole--polyphenols--antioxidant capacity--antiradical capacity
Аннотация: The synthesis of inhibitors for oxidative stress-associated destructive processes based on 2H-imidazole-derived phenolic compounds affording the bifunctional 2H-imidazole-derived phenolic compounds in good-to-excellent yields was reported. In particular, a series of bifunctional organic molecules of the 5-aryl-2H-imidazole family of various architectures bearing both electron-donating and electron-withdrawing substituents in the aryl fragment along with the different arrangements of the hydroxy groups in the polyphenol moiety, namely derivatives of phloroglucinol, pyrogallol, hydroxyquinol, including previously unknown water-soluble molecules, were studied. The structural and antioxidant properties of these bifunctional 5-aryl-2H-imidazoles were comprehensively studied. The redox transformations of the synthesized compounds were carried out. The integrated approach based on single and mixed mechanisms of antioxidant action, namely the AOC, ARC, Folin, and DPPH assays, were applied to estimate antioxidant activities. The relationship “structure-antioxidant properties” was established for each of the antioxidant action mechanisms. The conjugation effect was shown to result in a decrease in the mobility of the hydrogen atom, thus complicating the process of electron transfer in nearly all cases. On the contrary, the conjugation in imidazolyl substituted phloroglucinols was found to enhance their activity through the hydrogen transfer mechanism. Imidazole-derived polyphenolic compounds bearing the most electron-withdrawing functionality, namely the nitro group, were established to possess the higher values for both antioxidant and antiradical capacities. It was demonstrated that in the case of phloroglucinol derivatives, the conjugation effect resulted in a significant increase in the antiradical capacity (ARC) for a whole family of the considered 2H-imidazole-derived phenolic compounds in comparison with the corresponding unsubstituted phenols. Particularly, conjugation of the polyphenolic subunit with 2,2-dimethyl-5-(4-nitrophenyl)-2H-imidazol-4-yl fragment was shown to increase ARC from 2.26 to 5.16 (104 mol-eq/L). This means that the considered family of compounds is capable of exhibiting an antioxidant activity via transferring a hydrogen atom, exceeding the activity of known natural polyphenolic compounds.
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7.

Вид документа : Статья из журнала
Шифр издания : 54/S 98
Автор(ы) : Khonina T. G., Chupakhin O. N., Larionov L. P., Sorokin P. V., Zabokritskii N. A., Suvorov A. L., Shadrina E. V., Ivanenko M.V.
Заглавие : Synthesis and biological activity of organosilicontitanium glycerohydrogels [Electronic resource]
Место публикации : Pharmaceutical Chemistry Journal. - 2009. - Vol. 43, № 2. - С. 95-100
Систем. требования: http://www.springerlink.com/content/l41460241p017v47/fulltext.pdf
Примечания : 1.11.2011 г.
ББК : 54
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: A series of organosilicontitanium (OST) glycerohydrogels with the general formula 2Si(C3H7O3)4 Ti(C3H7O3)4 xC3H8O3 yH2O (where 9 x 30 and 60 y 120) were synthesized and some of their pharmacological properties were studied. High percutaneous activity of the compounds was revealed by measuring the diffusion of sodium diclofenac through intact skin membranes in vitro. It was established that all of the synthesized substances are nontoxic. The wound-healing and antioxidant properties of the glycerohydrogels were studied. The experimental results show that OST glycerohydrogels can be recommended for further testing as effective percutaneous vehicles of medicines with wound-healing, burn-healing, and antioxidant action
\\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2009, 43 (2), 95.pdf
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8.

Вид документа : Статья из журнала
Шифр издания : 54/A 62
Автор(ы) : Kogan G., Skorik Yu.A., Zitnanova I., Krizkova L., Durackova Z., Gomes C. A. R., Yatluk Yu. G., Krajcovic J.
Заглавие : Antioxidant and antimutagenic activity of N-(2-carboxyethyl)chitosan
Место публикации : Toxicology and Applied Pharmacology . - 2004. - Vol. 201, № 3. - С. 303-310: ил.
Примечания : Библиогр.: с. 309-310 (49 ref.)
ББК : 54
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The antioxidant and antimutagenic activities of the novel carboxyethyl derivatives of chitosan with three different degrees of substitution have been assayed in vitro in the unicellular flagellate Euglena gracilis subjected to the action of genotoxic agents acridine orange and ofloxacin. It has been demonstrated that chitosan derivatives exhibit concentration-dependent protective antigenotoxic activity against both mutagens. It is suggested that different mechanisms may be involved in its protective action—antioxidant activity in case of ofloxacin-induced DNA damage, as well as possible interaction with the cell membrane that prevents acridine orange from reaching the genetic compartments and subsequent damaging DNA through intercalative binding. Direct adsorption of acridine orange on chitosan derivatives was ruled out as a possible mechanism of protection on the basis of spectrophotometric measurements. Dependence of the antimutagenic properties of the studied chitosan derivatives on the degree of substitution was reversed in experiments involving acridine orange and ofloxacin, which also indicated different mechanisms of protection involved in these two cases.????
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9.

Вид документа : Статья из журнала
Шифр издания : 24
Автор(ы) : Makhaeva G. F., Lushchekina S. V., Boltneva N. P., Serebryakova O. G., Rudakova E. V., Ustyugov A. A., Bachurin S. O., Shchepochkin A. V., Chupakhin O. N., Charushin V. N., Richardson R. J.
Заглавие : 9-substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for alzheimer's disease treatment
Место публикации : Bioorganic and Medicinal Chemistry. - 2017. - Vol. 25, № 21. - С. 5981-5994
ББК : 24
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
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10.

Вид документа : Статья из сборника (однотомник)
Шифр издания : Г/R 19
Автор(ы) : Rammohan A., Garcia J. R., Zyryanov G. V.
Заглавие : Microwave assisted synthesis of n-substituted maleimide derivatives as exogenous antioxidant agents
Место публикации : Современные синтетические методологии для создания лекарственных препаратов и функциональных материалов (MOSM2018): вторая международная научно-практическая конференция : материалы и доклады. - Екатеринбург, 2019. - С. 130
ББК : Г
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
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