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Труды сотрудников Института органического синтеза УрО РАН - результаты поиска

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Каталог книг и продолжающихся изданий
Сводный каталог иностранных периодических изданий, имеющихся в библиотеках УрО РАН
Сводный каталог отечественных периодических изданий, имеющихся в библиотеках УрО РАН
Каталог диссертаций и авторефератов диссертаций УрО РАН
Каталог препринтов УрО РАН (1975 г. - )
Имидж-каталог отечественных книг (до 2010 г.)
Имидж-каталог иностранных книг (до 2010 г.)
Алфавитно-предметный указатель (АПУ) ЦНБ УрО РАН
Публикации об УрО РАН
Изобретения уральских ученых
Интеллектуальная собственность (статьи из периодики)
Нанотехнологии
Демидовские премии
Гибель династии Романовых
История Урала
Личная библиотека С. В. Вонсовского
Книжная коллекция Шубиных
Труды Института высокотемпературной электрохимии УрО РАН
Труды Института истории и археологии УрО РАН
Труды сотрудников Института горного дела УрО РАН
Труды сотрудников Института органического синтеза УрО РАН
Труды сотрудников Института теплофизики УрО РАН
Труды сотрудников Института химии твердого тела УрО РАН
Расплавы
Труды сотрудников ЦНБ УрО РАН
Публикации Черешнева В.А.
Публикации Чарушина В.Н.
Каталог библиотеки ИЭРиЖ УрО РАН
Электронная энциклопедия «Дискурсология»
Библиометрия
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 Найдено в других БД:Каталог книг и продолжающихся изданий (12)Труды Института высокотемпературной электрохимии УрО РАН (2)Труды сотрудников Института теплофизики УрО РАН (4)Труды сотрудников Института химии твердого тела УрО РАН (6)Публикации Чарушина В.Н. (148)Каталог библиотеки ИЭРиЖ УрО РАН (2)
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1.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Fatykhov R. F., Khalymbadzha I. A., Sharapov A. D., Potapova A. P., Starnovskaya E. S., Kopchuk D. S., Chupakhin O. N.
Заглавие : Expedient synthesis of 1,2,4-triazinyl substituted benzo[c]coumarins via double oxidation strategy
Место публикации : Chimica Techno Acta. - 2023. - Vol. 10, № 2. - С. 202310205
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): coumarin--1,2,4-triazine--nucleophilic substitution of hydrogen
Аннотация: Herein, we report a convenient one-pot synthesis of 1,2,4-triazinyl derivatives of benzocoumarins. The proposed approach consists of the nucleophilic addition of tetrahydrobenzo annulated dimethoxycoumarin to 1,2,4-triazines followed by double oxidation of both dihydrotriazine and tetrahydrobenzo groups with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The nucleophilic addition of the dimethoxycoumarin to 1,2,4-triazines was carried out in the presence of three-fold excess of methanesulfonic acid in DCM at room temperature. It takes place between positions 8 and 5 of coumarin and 1,2,4-triazine, respectively. The double oxidation step was carried out with 3.6 equivalent of DDQ. Selective oxidation of dihydrotriazine moiety, without affecting the tetrahydrobenzo fragment, was achieved using 1.2 equivalent of tetrachlorobenzoquinone (TCQ). The differences in the oxidation with TCQ and DDQ appear to be related to the higher oxidative potential of DDQ in contrast to TCQ. The advantages of the method are the elimination of the use of transition metals, the availability of starting materials, and the simplicity of the procedure. The proposed approach provides a two-step one-pot protocol for the synthesis of triazinyl benzocoumarins, precursors for the preparation of push-pull pyridinyl chromophore.
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2.

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Kir'yanova T. D., Egorova D. O., Gorbunova T. I., Pervova M. G.
Заглавие : Bacterial degradation of PCB 70 and its hydroxy derivatives is an environmentally friendly way to destroy pops
Место публикации : Bio Web of Conferences : International Scientific and Practical Conference “Innovations, Technological Solutions and Management in Modern Biotechnology and Biomedicine” (ITSM-2022). - Pushchino, 2023. - С. 09002
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: One of the problems of our time is the environmentally safe destruction of polychlorinated biphenyls (PCBs) and their hydroxylated derivatives. The aim of the study was to investigate the features and prospects of the decomposition of PCB 70 (2,5,3',4'-tetrachlorobiphenyl) and hydroxylated chlorobiphenyls derived from it by Rhodococcus wratislaviensis strain CH628. As a result of the application of methods of periodic cultivation, gas chromatography and light spectrometry, it was found that the efficiency of destruction of PCB 70 1 g of cells of strain CH628 was 90 mg PCB/day, and the same indicator for a mixture consisting of hydroxy derivatives obtained from PCB 70 was 56 mg PCB/day. It was shown that the strain uses all components of the mixture of hydroxy-PCB 70 as a growth substrate, but with different degradation rates. When cultivated in a mineral medium with PCB 70 or a mixture of hydroxy-PCB 70, strain CH628 forms biofilms. The analysis of the obtained results shows that the use of the Rhodococcus wratislaviensis CH628 strain will make it possible to develop a technology for the environmentally safe destruction of PCB 70 and hydroxy-PCBs derived from it.
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3.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Slepukhin P. A., Krinochkin A. P., Starnovskaya E. S., Shtaitz Y. K., Savchuk M. I., Kopchuk D. S., Egorov I. N., Santra S., Zyryanov G. V., Chupakhin O. N.
Заглавие : Single-crystal X-ray diffraction analysis of arylamine-containing 2,2′-bipyridine derivatives
Место публикации : Russian chemical bulletin. - 2022. - Vol. 71, № 7. - С. 1533-1543
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The structures of six 2,2′-bipyridine derivatives containing aromatic amine moieties, namely N-aryl-4-aryl-1-(pyridin-2-yl)-6,7-dihydro-5H-cyclopenta[c]pyridine-3-amines, were studied by single-crystal X-ray diffraction. The molecular structures and the effect of the substituents of these compounds on the crystal packing are discussed.
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4.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Nosova E. V., Kopotilova A. E., Ivan’kina M. A., Moshkina T. N., Kopchuk D. S.
Заглавие : Synthesis of 5-(4-bromophenyl)- and 5-(5-bromothiophen-2-yl)-substituted 3-aryl[1,2,4]triazolo[4,3-c]quinazolines
Место публикации : Russian chemical bulletin. - 2022. - Vol. 71, № 7. - С. 1483-1487
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: A series of [1,2,4]triazolo[4,3-c]quinazolines, bearing 3-positioned p-bromophenyl or 5-bromothiophen-2-yl fragment, was synthesized by oxidative cyclization of the corresponding hydrazones with bromine in glacial acetic acid at room temperature. The obtained tricyclic derivatives are valuable intermediates for biologically active compounds and fluorophores.
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5.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Korolyova M. A., Vigorov A. Yu., Krasnov V. P.
Заглавие : Theoretical study of the stereoselectivity in the reaction of 4-haloglutamic acid derivatives with arylamines
Место публикации : Russian chemical bulletin. - 2022. - Vol. 71, № 6. - С. 1135-1142
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: Diastereoselective nucleophilic substitution reaction of halogen in dimethyl (2S,4RS)-4-bromo- and 4-iodo-N-phthaloylglutamates with arylamines was studied within the framework of the electron density functional theory. According to calculations, the stereoselectivity of the substitution reaction with respect to (2S,4S)-isomers of 4-arylamino derivatives is determined not only by the steric hindrances in the transition state leading to minor (2S,4R)-diastereomers, but also by the stabilization of the corresponding initial reagents complex due to stacking interactions of the aromatic fragments of reagents.
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6.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Fatykhov R. F., Sharapov A. D., Starnovskaya E. S., Shtaitz Y. K., Savchuk M. I., Kopchuk D. S., Nikonov I. L., Zyryanov G. V., Khalymbadzha I. A., Chupakhin O. N.
Заглавие : Coumarin-pyridine push-pull fluorophores: synthesis and photophysical studies
Место публикации : Spectrochimica acta part A: molecular and biomolecular spectroscopy. - 2022. - Vol. 267. - Ст.120499
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: A series of coumarin-pyridine-based push-pull fluorophores were prepared starting from 1,2,4-triazines by using direct C-H functionalization (SNH-reaction)–Diels-Alder–retro Diels-Alder domino reaction sequence. This efficient synthetic strategy allowed to obtain a series of 19 coumarin-pyridine fluorophores. Their photophysical properties were studied. While pyridine-substituted derivatives of 4-alkylcoumarins may be considered as alternative to coumarin dyes characterized by emission maxima mainly in a visible region with wavelengths of 402–415 nm, absorption in the UV range at 210–307 nm, and good photoluminescence quantum yields of 6–19%, all the derivatives of 4-phenylcoumarin did not exhibit any noticeable fluorescence. More detailed photophysical studies were carried out for two the most representative derivatives of 4-alkyl-coumarin-pyridines to demonstrate their positive solvatochromism, and the collected data were analyzed by using Lippert-Mataga equation, as well as Kosower and Dimroth/Reichardt scales. The obtained results demonstrate that the combining two chromophore systems, such as 2,5-diarylpyridine and coumarin ones, is promising in terms of improving the photophysical properties of the new coumarin-pyridine hybrid compounds.
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7.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kolesnikova T. O., Demin K. A., Kalueff A. V., Galstyan D. S., Barabanov M.A., Pestov A. V., S de Abreu M., Strekalova T.
Заглавие : Pharmacological characterization of a novel putative nootropic beta-alanine derivative, MB-005, in adult zebrafish
Место публикации : Journal of Psychopharmacology. - 2022. - Vol. 36, № 7. - С. 779-902
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: Cognitive deficits represent an urgent biomedical problem, and are commonly reduced by nootropic drugs. Animal models, including both rodents and zebrafish, offer a valuable tool for studying cognitive phenotypes and screening novel nootropics. Beta-alanine and its derivatives have recently been proposed to exert nootropic activity.
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8.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gruzdev D.A., Telegina A. A., Levit G. L., Krasnov V. P.
Заглавие : N-aminoacyl-3-amino-nido-carboranes as a group of boron-containing derivatives of natural amino acids
Место публикации : Journal of Organic Chemistry. - 2022. - Vol. 87, № 8. - С. 5437-5441
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: A new group of nido-carboranyl derivatives of natural (S)-amino acids containing from 9 to 18 boron atoms was obtained in good yields as a result of acylation of 3-amino-1,2-dicarba-closo-dodecaborane followed by deboronation. The proposed approach is convenient and based on the use of readily available reagents and is suitable for the synthesis of enantiopure nido-carboranyl derivatives of amino acids with various side chains, including water-soluble boron-containing amino acids (17 examples).
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9.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Solovyova Y. V., Pestov A. V., Puzyrev I. S., Pervova M. G., Kuznetsov V. A., Vlasov I. A., Artemiev G. A.
Заглавие : Synthesis of δ-Valerolactone Using Stable Hydrogen Peroxide Derivatives
Место публикации : Russian Journal of Organic Chemistry. - 2022. - Vol. 58, № 4. - С. 480-483
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The efficiencies of hydrogen peroxide derivatives in the Baeyer–Villiger oxidation of cyclopen­tanone to δ-valerolactone have been compared. The oxidants used were hydrogen peroxide in acetic, formic, or trifluoroacetic acid, magnesium and sodium monoperoxyphthalates, cumene hydroperoxide, and tert-butyl hydroperoxide. The oxidation was carried out in water, aqueous methanol, and water–ethyl acetate. Sodium and magnesium monoperoxyphthalates turned out to provide high conversion and selectivity under mild conditions.
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10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Sharapov A. D., Fatykhov R. F., Khalymbadzha I. A., Santra S., Zyryanov G. V., Chupakhin O. N., Sharutin V. V., Ranu B. C.
Заглавие : Mechanochemical synthesis of coumarins via Pechmann condensation under solvent-free conditions: an easy access to coumarins and annulated pyrano[2,3-f] and [3,2-f]indoles
Место публикации : Green Chemistry. - 2022. - Vol. 24, № 6. - С. 2429-2437
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): a green protocol has been developed for the synthesis of simple coumarins and linear pyrano[2,3-f] and [3,2-f]indoles by the reaction of phenol derivatives with β-ketoesters under ball milling at ambient temperature in the presence of methanesulfonic acid as a mild acid catalyst. the significant advantages of this procedure are high yields, scalability, no use of hazardous acids or solvents, shorter reaction time, ambient temperature, low cost, and straightforward purification without column chromatography. this procedure is associated with high ecoscale metrics and a low e-factor. in contrast to traditional pechmann condensation procedures, the mechanochemical protocol leads to the synthesis of pyranoindoles with excellent regioselectivity and high yields.
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11.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Sankar P. S., Babu K. N., Padmavathi V., Sravya G., Zyryanov G. V., Sudheer K.
Заглавие : Bis(azolyl)sulfonamidoacetamides: Synthesis and bioassay
Место публикации : AIP conference proceedings. - 2022. - Vol. 2390. - Ст.020021
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): antimicrobials--bioassays--antifungal
Аннотация: Azole derivatives are valuable precursors in pharmacological arena. In fact, oxazole, thiazole and imidazole containing scaffolds display a variety of biological activities such as antitumor,1 antibacterial,2 antiviral,3 antioxidant,4,5 anti-inflammatory6 and antifungal7 activities. Azoles are also prominant molecules in various biochemical and synthetic transformations. Based on the importance of these heteroaromatics and also our interest to link the heterocycle molecules with a variety of functional groups we have synthesized a new class of bis(azolyl)sulfonamide acetamides from azolylsulfonylamines and azolylchloroacetamides in the presence of DMAP under ultrasonication and studied their antimicrobial activity. The compounds chloro substituted bis(thiazoles) (6c) and chloro substituted imidazolyl thiazoles (7c) displayed excellent antibacterial activity against B. subtilis greater than the standard drug, Chloramphenicol. Whereas 7c also showed excellent antifungal activity on A. niger higher than the standard drug, Ketoconazole.
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12.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Telegina A. A., Gruzdev D.A., Levit G. L., Krasnov V. P.
Заглавие : Synthesis of new conjugates of 6-thiopurine and thioguanine with (S)-glutamic acid
Место публикации : Russian chemical bulletin. - 2022. - Vol. 71, № 11. - С. 2426-2430
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: We have developed an efficient method for the synthesis of 6-thiopurine and thioguanine conjugates containing a (S)-glutamic acid residue, which is based on the reaction of 6-thio derivatives of purine with di-tert-butyl N-chloroacetyl-(S)-glutamate and subsequent hydrolysis of the ester groups.
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13.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gruzdev D.A., Telegina A. A., Ol’shevskaya V. A., Andronova V. L., Galegov G. A., Zarubaev V. V., Levit G. L., Krasnov V. P.
Заглавие : New nido-carborane-containing conjugates of purine: synthesis and antiviral activity
Место публикации : Russian chemical bulletin. - 2022. - Vol. 71, № 11. - С. 2375-2382
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
ХИМИЧЕСКИЕ НАУКИ
Аннотация: New purine derivatives containing a nido-carborane fragment were synthesized by nucleophilic substitution of chlorine atom in 6-chloropurine and 2-amino-6-chloropurine under the action of nido-carborane-containing amines. Compounds with significant activity against the acyclovir-resistant strain of herpes simplex virus type 1, as well as with moderate activity against influenza viruses A and B, were discovered for the first time among the synthesized nido-carboranyl derivatives of purine.
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14.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zharkov G. P., Filimonova O. V., Petrova Y. S., Pestov A. V., Neudachina L. K.
Заглавие : Complexing properties of N-[1,1-bis(hydroxymethyl)ethyl]-and N-[tris(hydroxymethyl)methyl]-β-alanine
Место публикации : Russian chemical bulletin. - 2022. - Vol. 71, № 1. - С. 152–157
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): β-alanine
Аннотация: Protolytic and complexing properties of N-[1,1-bis(hydroxymethyl)ethyl]- and N-[tris-(hydroxymethyl)methyl]-β-alanine were estimated using the potentiometry. Values of the dissociation constants of amino and carboxyl functional groups in molecules of these reagents, as well as the stability constants of their complexes of various compositions with copper(II), cobalt(II), nickel(II), zinc(II), cadmium(II), silver(I), magnesium(II), calcium(II), strontium(II), and barium(II) ions, were calculated. The hydroxyalkylation of β-alanine tunes its properties towards the considered metal ions. Complexes of copper(II) ions with these β-alanine derivatives are the most stable complex compounds among explored herein.
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15.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Krasnov V. P., Musiyak V. V. , Levit G. L., Gruzdev D.A., Charushin V. N., Andronova V. L., Galegov G. A., Orshanskaya I. R., Sinegubova E. O., Zarubaev V. V.
Заглавие : Synthesis of pyrimidine conjugates with 4-(6-amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2h-[1,4] benzoxazine and evaluation of their antiviral activity
Место публикации : Molecules. - 2022. - Vol. 27, № 13. - Ст.4236
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): pyrimidine
Аннотация: A series of pyrimidine conjugates containing a fragment of racemic 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its (S)-enantiomer attached via a 6-aminohexanoyl fragment were synthesized by the reaction of nucleophilic substitution of chlorine in various chloropyrimidines. The structures of the synthesized compounds were confirmed by 1H, 19F, and 13C NMR spectral data. Enantiomeric purity of optically active derivatives was confirmed by chiral HPLC. Antiviral evaluation of the synthesized compounds has shown that the replacement of purine with a pyrimidine fragment leads to a decrease in the anti-herpesvirus activity compared to the lead compound, purine conjugate. The studied compounds did not exhibit significant activity against influenza A (H1N1) virus.
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16.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Verbitskiy E. V., Kvashnin Y. A., Rusinov G. L., Charushin V. N., Le Poul P., Achelle S., Bures F., Barsella A.
Заглавие : Push–pull derivatives based on 2,4'-biphenylene linker with quinoxaline, [1,2,5]oxadiazolo[3,4-b]pyrazine and [1,2,5]thiadiazolo[3,4-b]pyrazine electron withdrawing parts
Место публикации : Molecules. - 2022. - Vol. 27, № 13. - Ст.4250
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: A series of novel V-shaped quinoxaline, [1,2,5]oxadiazolo[3,4-b]pyrazine and [1,2,5]thiadiazolo[3,4-b]pyrazine push–pull derivatives with 2,4′-biphenylene linker were designed and their electrochemical, photophysical and nonlinear optical properties were investigated. [1,2,5]Oxadiazolo[3,4-b]pyrazine is the stronger electron-withdrawing fragment as shown by electrochemical, and photophysical data. All compounds are emissive in a solid-state (from the cyan to red region of the spectrum) and quinoxaline derivatives are emissions in DCM solution. It has been found that quinoxaline derivatives demonstrate important solvatochromism and extra-large Stokes shifts, characteristic of twisted intramolecular charge transfer excited state as well as aggregation induced emission. The experimental conclusions have been justified by theoretical (TD-)DFT calculations.
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17.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kvashnin Yu. A., Verbitskiy E. V., Rusinov G. L., Charushin V. N.
Заглавие : Modification and application of 1,2,5-oxadiazolo[3,4-b]pyrazine derivatives: highlights and perspectives
Место публикации : Russian chemical bulletin. - 2022. - Vol. 71, № 7. - С. 1342-1362
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
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18.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Mukherjee A., Kopchuk D. S., Kovalev I. S., Santra S., Varaksin M. V., Zyryanov G. V., Chupakhin O. N., Charushin V. N., Majee A.
Заглавие : Direct C−H functionalization of calix[N](het)arenes (N=4,6): a brief update
Место публикации : ChemistrySelect. - 2022. - Vol. 7, № 12. - С. e202103017
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: Calix[n]arenes, their hetero derivatives, are the most popular hosts for the supramolecular and materials chemistry as they can form stable inclusion complexes with charged or neutral molecules, including gases. This short review highlights the most prospective synthetic approaches for direct modification of calix[4]arene core with various functional moieties as well as selected patterns of direct C−H-modification of calix[6]arenes and calix[4]pyrroles.
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19.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Charushin V. N., Rusinov V. L., Varaksin M. V., Chupakhin O. N., Kovtun O. P., Spasov A. A.
Заглавие : Development of drugs with direct antiviral action based on azaheterocyclic systems
Место публикации : Herald of the Russian academy of sciences. - 2022. - Vol. 92, № 4. - С. 505-510
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
ХИМИЧЕСКИЕ НАУКИ
Аннотация: This article discusses the results of studies carried out in recent years by a team of scientists from the Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, in cooperation with the First President of Russia Boris Yeltsin Ural Federal University, Ural State Medical University, Volgograd State Medical University, and other scientific and production organizations of the country to create triazavirin (riamilovir) and other direct etiotropic antiviral drugs based on azaheterocyclic derivatives.
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20.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Artem'ev G. A., Rusinov V. L., Kopchuk D. S., Savchuk M. I., Ulomsky E. N., Zyryanov G. V., Charushin V. N., Chupakhin O. N., Santra S., Majee A., Du W.
Заглавие : Synthetic approaches to 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-ones as basic heterocyclic structures of the antiviral drug Riamilovir (“Triazavirin®”) active against SARS-CoV-2 (COVID-19)
Место публикации : Organic & biomolecular chemistry. - 2022. - Vol. 20, № 9. - С. 1828-1837
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Fragments of 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one are found in many compounds with various types of biological activities, including the antiviral drug Riamilovir (Triazavirin®), which shows activity against SARS-CoV-2 (COVID-19). Therefore, the development of convenient methods for the synthesis of new derivatives of 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one is always in demand. This review systematizes the information on the most common synthetic methods for constructing the 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one heterocyclic system.
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