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Труды сотрудников Института органического синтеза УрО РАН - результаты поиска

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Каталог книг и продолжающихся изданий
Сводный каталог иностранных периодических изданий, имеющихся в библиотеках УрО РАН
Сводный каталог отечественных периодических изданий, имеющихся в библиотеках УрО РАН
Каталог диссертаций и авторефератов диссертаций УрО РАН
Каталог препринтов УрО РАН (1975 г. - )
Имидж-каталог отечественных книг (до 2010 г.)
Имидж-каталог иностранных книг (до 2010 г.)
Алфавитно-предметный указатель (АПУ) ЦНБ УрО РАН
Публикации об УрО РАН
Изобретения уральских ученых
Интеллектуальная собственность (статьи из периодики)
Нанотехнологии
Демидовские премии
Гибель династии Романовых
История Урала
Личная библиотека С. В. Вонсовского
Книжная коллекция Шубиных
Труды Института высокотемпературной электрохимии УрО РАН
Труды Института истории и археологии УрО РАН
Труды сотрудников Института горного дела УрО РАН
Труды сотрудников Института органического синтеза УрО РАН
Труды сотрудников Института теплофизики УрО РАН
Труды сотрудников Института химии твердого тела УрО РАН
Расплавы
Труды сотрудников ЦНБ УрО РАН
Публикации Черешнева В.А.
Публикации Чарушина В.Н.
Каталог библиотеки ИЭРиЖ УрО РАН
Электронная энциклопедия «Дискурсология»
Библиометрия
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1.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Fatykhov R. F., Khalymbadzha I. A., Sharapov A. D., Potapova A. P., Starnovskaya E. S., Kopchuk D. S., Chupakhin O. N.
Заглавие : Expedient synthesis of 1,2,4-triazinyl substituted benzo[c]coumarins via double oxidation strategy
Место публикации : Chimica Techno Acta. - 2023. - Vol. 10, № 2. - С. 202310205
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): coumarin--1,2,4-triazine--nucleophilic substitution of hydrogen
Аннотация: Herein, we report a convenient one-pot synthesis of 1,2,4-triazinyl derivatives of benzocoumarins. The proposed approach consists of the nucleophilic addition of tetrahydrobenzo annulated dimethoxycoumarin to 1,2,4-triazines followed by double oxidation of both dihydrotriazine and tetrahydrobenzo groups with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The nucleophilic addition of the dimethoxycoumarin to 1,2,4-triazines was carried out in the presence of three-fold excess of methanesulfonic acid in DCM at room temperature. It takes place between positions 8 and 5 of coumarin and 1,2,4-triazine, respectively. The double oxidation step was carried out with 3.6 equivalent of DDQ. Selective oxidation of dihydrotriazine moiety, without affecting the tetrahydrobenzo fragment, was achieved using 1.2 equivalent of tetrachlorobenzoquinone (TCQ). The differences in the oxidation with TCQ and DDQ appear to be related to the higher oxidative potential of DDQ in contrast to TCQ. The advantages of the method are the elimination of the use of transition metals, the availability of starting materials, and the simplicity of the procedure. The proposed approach provides a two-step one-pot protocol for the synthesis of triazinyl benzocoumarins, precursors for the preparation of push-pull pyridinyl chromophore.
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2.

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Krasikova A. P., Andreykov E. I., Dikovinkina Yu. A., Pervova M. G., Antonov D. O.
Заглавие : Hydrogen-donor properties of the anthracene fraction of coal tar in the reactions of thermal solvolysis
Место публикации : Coal chemistry and ecology of Kuzbass : XII International Russian-Kazakh Symposium. - Kemerovo, 2023. - С. 50
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The reactions of hydrogen transfer from anthracene oil to model organic compounds – hydrogen acceptors are investigated. Solvolysis of thermosetting polymers in anthracene oil has been carried out.
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3.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Solovyova Y. V., Pestov A. V., Puzyrev I. S., Pervova M. G., Kuznetsov V. A., Vlasov I. A., Artemiev G. A.
Заглавие : Synthesis of δ-Valerolactone Using Stable Hydrogen Peroxide Derivatives
Место публикации : Russian Journal of Organic Chemistry. - 2022. - Vol. 58, № 4. - С. 480-483
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The efficiencies of hydrogen peroxide derivatives in the Baeyer–Villiger oxidation of cyclopen­tanone to δ-valerolactone have been compared. The oxidants used were hydrogen peroxide in acetic, formic, or trifluoroacetic acid, magnesium and sodium monoperoxyphthalates, cumene hydroperoxide, and tert-butyl hydroperoxide. The oxidation was carried out in water, aqueous methanol, and water–ethyl acetate. Sodium and magnesium monoperoxyphthalates turned out to provide high conversion and selectivity under mild conditions.
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4.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Andreikov E. I., Krasikova A. P., Pervova M. G., Kabak A. S.
Заглавие : Investigation of hydrogen transfer from coal tar pitch and petroleum pitches using a-methylstyrene as hydrogen acceptor
Место публикации : Chemistry for sustainable development. - 2022. - Vol. 30, № 5. - С. 446-454
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): a-methylstyrene--coal tar pitch--petroleum pitches
Аннотация: The reaction of hydrogen transfer from coal tar pitch and petroleum pitches to Α-methylstyrene with the formation of cumene was investigated in glass ampoules within the temperature range of 200-360 °C and reaction time of 15-60 min and when passing Α-methylstyrene through a layer of coal tar pitch. It is shown that the formation of non-chromatographable products of Α-methylstyrene condensation with polycyclic aromatic compounds of pitches occurs simultaneously. The dependences of Α-methylstyrene conversion, the selectivity for cumene and condensation products on the temperature and reaction time, the ratio of pitch/Α-methylstyrene are determined. The amount of hydrogen transferred from pitches to Α-methylstyrene was determined, and the results obtained were compared with the literature data on the transfer of hydrogen from pitches obtained using anthracene as a hydrogen acceptor.
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5.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Taniya O. S., Fedotov V. V., Sadieva L. K., Krinochkin A. P., Kovalev I. S., Kopchuk D. S., Zyryanov G. V., Ulomsky E. N., Rusinov V. L., Charushin V. N., Novikov A. S., Liu Y.
Заглавие : Abnormal push-pull benzo[4,5]imidazo[1,2-a][1,2,3]triazolo[4,5-e]pyrimidine fluorophores in planarized intramolecular charge transfer (PLICT) state: Synthesis, photophysical studies and theoretical calculations
Место публикации : Dyes and Pigments. - 2022. - Vol. 204. - Ст.110405
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The combination of excellent luminescence with high solvent polarity effect and aggregation induced emission (AIE) is an ideal combination for creating fluorophores/probes with high microenvironmental sensitivity. However, many push-pull chromophores of the D−A type in common intramolecular charge transfer (ICT) state with a significant solvatochromic effect and AIE activity, have poor luminescent properties. Herein, to overcome this problem by using reactions of nucleophilic aromatic hydrogen substitution (SNH), we have designed a series of novel 4-heteroaryl-substituted 2-aryl-2H-benzo[4,5]imidazo[1,2-a][1,2,3]triazolo[4,5-e]pyrimidine fluorophores possessing a planarized intramolecular charge transfer (PLICT) state. All these fluorophores exhibited high luminescence quantum yields (up to 60%) and large Stokes shift values of up to 7459 cm−1. Among them, the fluorophore 4h was found to exhibit the most pronounced positive solvatochromic effect and the probe 4f exhibited the most pronounced aggregation induced emission characteristics. This AIE behavior was further confirmed by means of time-resolved fluorescence lifetime measurements as well as DFT-assisted geometry optimization studies. In the presence of trifluoroacetic acid (TFA) compound 4h exhibited a well-pronounced acidochromism via visible color change from yellow-green to orange which returned to the original yellow-green solution after the addition of triethylamine (TEA). The Stern-Volmer constant for the probe 4h towards TFA was 38 M−1. Finally, for the compounds 4f, g, h theoretical calculations in the ground and excited states in different solvents were carried out to confirm the PLICT process. Based on all above the herein reported PLICT fluorophores 4a-h can be successfully applied as biological probes and optical switches.
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6.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Dorosheva I. B., Valeeva A. A., Rempel A. A., Trestsova M. A., Utepova I. A., Chupakhin O. N.
Заглавие : Synthesis and physicochemical properties of nanostructured TiO2 with enhanced photocatalytic activity
Место публикации : Inorganic Materials. - 2021. - Vol. 57, № 5. - С. 503-510
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): titanium dioxide--sol–gel method--photocatalysis
Аннотация: Nanostructured titanium dioxide (TiO2) with a crystallite size from 10 to 85 nm, photocatalytically active for organic reactions under illumination with visible light, has been prepared by a sol–gel process using a titanium tetrabutoxide solution in ethanol with an initial pH of 6. According to X-ray diffraction characterization results, the as-prepared titanium dioxide was amorphous. Annealing in a hydrogen atmosphere for 1 h at 400°C led to the formation of an anatase phase, and annealing in the temperature range from 600 to 800°C resulted in the anatase–rutile phase transition. The crystallite size of titanium dioxide increased from 10 to 75 nm as the annealing temperature was raised from 400 to 1000°C (furnace annealing for 1 h) and from 60 to 85 nm as the annealing time at a temperature of 800°C was increased from 30 to 240 min. Diffuse reflection spectra showed that the band gap of TiO2 decreased from 3.3 to 2.6 eV as the annealing temperature was raised from 200 to 1000°C. The specific surface area data obtained by BET measurements showed that the samples annealed at the highest temperature (1000°C) had the smallest surface area, which dropped from 307 to 1m2/g. The efficiency of the synthesized TiO2 tested as a catalyst for oxidative S H N cross-coupling of acridine with indole demonstrated an in crease in product yield from 35 to 80% as the annealing temperature was raised to 800°C. Varying the 800°C annealing time from 30 to 180 min had no effect on the reaction product yield, which ranged from 70 to 80%.
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7.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Obydennov K. L., Kalinina T. A., Galieva N. A., Beryozkina T., Glukhareva T. V., Bakulev V. A., Zhang Y., Fan Z.
Заглавие : Synthesis, fungicidal activity, and molecular docking of 2-acylamino and 2-thioacylamino derivatives of 1 H-benzo[ d]imidazoles as anti-tubulin agents
Место публикации : Journal of agricultural and food chemistry. - 2021. - Vol. 69, № 40. - С. 12048-12062
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): benzimidazoles--antifungal activity--tubulin--carbendazim
Аннотация: This work deals with the synthesis and evaluation of fungicidal activity of benzimidazole derivatives, which are structural analogues of commercial anti-tubulin fungicides. A number of N-acyl and N-thioacyl derivatives of 2-amino-1H-benzo[d]imidazole were prepared, and their fungicidal activity against 13 strains of phytopathogenic fungi was studied. The most active compounds against the majority of the studied strains were 3a, 4l, and 4o, and the EC50 values of these compounds were in the range 2.5–20 μg/mL. Compound 3a showed the highest activity against the P. infestans strain, the growth of which is not suppressed by carbendazim. The formation of ligand–receptor complexes of various tautomeric forms of the studied benzimidazoles with homologous models of β-tubulins of B. cinerea, F. oxysporum, and P. infestans was modeled. Induced fit docking has been used for the simulation. The obtained data suggest the possibility of binding of benzimidazole fungicides to β-tubulin in the ″nocodazole cavity″ in the tautomeric form bearing a double exocyclic C═N bond. The importance of the formation of hydrogen bonds of benzimidazoles with the amino acid residue Val236 along with the Glu198 residue is also revealed in the present study.
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8.

Вид документа : Статья из журнала
Шифр издания : Г/D 46
Автор(ы) : Gerasimova E. L., Gazizullina E. R., Borisova M. V., Igdisanova D. I., Nikiforov E. A., Moseev T. D., Varaksin M. V., Chupakhin O. N., Charushin V. N., Ivanova A. V.
Заглавие : Design and antioxidant properties of bifunctional 2H-imidazole-derived phenolic compounds-a new family of effective inhibitors for oxidative stress-associated destructive processes
Место публикации : Molecules. - 2021. - Vol. 26, № 21. - Ст.6534
ББК : Г
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): 2h-imidazole--polyphenols--antioxidant capacity--antiradical capacity
Аннотация: The synthesis of inhibitors for oxidative stress-associated destructive processes based on 2H-imidazole-derived phenolic compounds affording the bifunctional 2H-imidazole-derived phenolic compounds in good-to-excellent yields was reported. In particular, a series of bifunctional organic molecules of the 5-aryl-2H-imidazole family of various architectures bearing both electron-donating and electron-withdrawing substituents in the aryl fragment along with the different arrangements of the hydroxy groups in the polyphenol moiety, namely derivatives of phloroglucinol, pyrogallol, hydroxyquinol, including previously unknown water-soluble molecules, were studied. The structural and antioxidant properties of these bifunctional 5-aryl-2H-imidazoles were comprehensively studied. The redox transformations of the synthesized compounds were carried out. The integrated approach based on single and mixed mechanisms of antioxidant action, namely the AOC, ARC, Folin, and DPPH assays, were applied to estimate antioxidant activities. The relationship “structure-antioxidant properties” was established for each of the antioxidant action mechanisms. The conjugation effect was shown to result in a decrease in the mobility of the hydrogen atom, thus complicating the process of electron transfer in nearly all cases. On the contrary, the conjugation in imidazolyl substituted phloroglucinols was found to enhance their activity through the hydrogen transfer mechanism. Imidazole-derived polyphenolic compounds bearing the most electron-withdrawing functionality, namely the nitro group, were established to possess the higher values for both antioxidant and antiradical capacities. It was demonstrated that in the case of phloroglucinol derivatives, the conjugation effect resulted in a significant increase in the antiradical capacity (ARC) for a whole family of the considered 2H-imidazole-derived phenolic compounds in comparison with the corresponding unsubstituted phenols. Particularly, conjugation of the polyphenolic subunit with 2,2-dimethyl-5-(4-nitrophenyl)-2H-imidazol-4-yl fragment was shown to increase ARC from 2.26 to 5.16 (104 mol-eq/L). This means that the considered family of compounds is capable of exhibiting an antioxidant activity via transferring a hydrogen atom, exceeding the activity of known natural polyphenolic compounds.
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9.

Вид документа : Статья из журнала
Шифр издания : Г/S 98
Автор(ы) : Shabunina O. V., Shtaitz Y. K., Kopchuk D. S., Krinochkin A. P., Santra S., Zyryanov G. V., Wang Z., Rusinov V. L., Chupakhin O. N.
Заглавие : Synthesis of novel 3-(pyridin-4-yl)-1,2,4-triazines, their analogs and study of the activity against vaccinia virus
Место публикации : Chemistry of Heterocyclic Compounds. - 2021. - Vol. 57, № 4. - С. 462–466
УДК : Г
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): 1,2,4-triazines--antiviral activity--ipso substitution--nucleophilic hydrogen substitution
Аннотация: Using atom-economical approaches, new representatives of 3-(pyridin-4-yl)-1,2,4-triazines and their 4-nitrophenyl analogs were obtained, and their activity in relation to the vaccinia virus was studied. The new compounds have shown promising characteristics, in particular, in comparison to the antiviral drug Cidofovir.
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10.

Вид документа : Статья из журнала
Шифр издания : Г/B 68
Автор(ы) : Akulov A. A., Varaksin M. V., Tsmokalyuk A. N., Charushin V. N., Chupakhin O. N.
Заглавие : Blue-light-promoted radical c-h azolation of cyclic nitrones enabled by selectfluor®
Место публикации : Green Chemistry. - 2021. - Vol. 23, № 5. - С. 2049-2057
ББК : Г
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: An original approach to achieve the C(sp2)–H azolation of cyclic aldonitrones mediated by Selectfluor® has first been employed. By exploiting a metal-free, visible-light-promoted cross-dehydrogenative C–N coupling reaction between model aldonitrones, 2H-imidazole 1-oxides, and NH-containing azoles, a series of novel azaheterocyclic derivatives have been obtained in yields up to 94%. The elaborated protocol has proved to be appropriate for gram-scale processes and displayed potential for utilization in the synthesis of novel structural analogues of lanabecestat. Besides, mechanistic studies have revealed that this coupling reaction is likely to proceed via a nitroxide-involving radical pathway, encompassing a chain of electron transfer events, such as hydrogen atom transfer (HAT) and single electron transfer (SET).
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11.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Moseev T. D., Nikiforov E. A., Varaksin M. V., Charushin V. N., Chupakhin O. N.
Заглавие : Metal-free C-H/C-H coupling of 2 H-imidazole 1-oxides with polyphenols toward imidazole-linked polyphenolic compounds
Место публикации : Journal of Organic Chemistry. - 2021. - Vol. 86, № 19. - С. 13702–13710
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The methodology of nucleophilic substitution of hydrogen (SNH) was successfully applied as a convenient synthetic tool to afford azaheterocyclic derivatives of phenols of various architectures. A series of 26 novel imidazole-linked polyphenolic compounds were first prepared in 72–95% yields through the direct metal-free C–H/C–H coupling of polyphenols with 2H-imidazole 1-oxides. Comprehensive studies on the reaction condition optimization, scope, and limitations enabled the development of a straightforward method toward novel bifunctional derivatives bearing both phenolic and imidazole scaffolds of particular interest in the design of challenging molecules for versatile applications in medicinal chemistry and materials science.
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12.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Moseev T. D., Lavrinchenko I. A., Varaksin M. V., Charushin V. N., Chupakhin O. N., Pobedinskaya D. Y., Demidov O. P., Borovlev I. V.
Заглавие : Meso-functionalization of calix[4]arene with 1,3,7-triazapyrene in the design of novel fluorophores with the dual target detection of Al3+ and Fe3+ cations
Место публикации : RSC Advances. - 2021. - Vol. 11, № 11. - С. 6407-6414
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: A meso-functionalization strategy has successfully been applied to the synthesis of novel 1,3,7-triazapyrene derivatives of calixarenes. The key synthetic step in these transformations providing the direct C–C bond formation is nucleophilic substitution of hydrogen (SNH) in 1,3,7-triazapyrene. General photophysical characteristics for these macrocyclic compounds, as well as features in emission properties upon addition of various metal cations have been elaborated. Studies using NMR spectroscopy have also shown a mutual effect of both calix[4]arene and 1,3,7-triazapyrene moieties on the coordination process. The complex stoichiometry and binding constants for Al3+ and Fe3+ guests have been explored with titration experiments.
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13.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Aitbekova D. E., Makenov D. K., Andreikov E. I., Tsaur A. G., Feng Yung Ма, Baikenova G. G., Tusipkhan A., Muratbekova A. A., Baikenov M. I.
Заглавие : Hydrogen distribution in primary coke oven tar and its fractions
Место публикации : Bulletin of the Karaganda university. Chemistry series. - 2021. - № 1. - С. 82-90
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): primary coke oven tar--ir spectroscopy--pmr spectroscopy--elemental analysis--hydrogen distribution
Аннотация: The aim of this work is to determine the hydrogen distribution in primary coke oven tar and its fractions. The hydrogen distribution in the primary coke oven tar of «ShubarkolKomir» JSC, its distillate fractions and distillation residue have been determined by the methods of elemental analysis, IR and PMR spectroscopy. The atomic ratio of C: H in the primary coke oven tar is 0.79. All fractions of the tar contain a large amount of alkyl-substituted aromatic compounds, phenols and other substances with alkyl groups. The initial tar characterized by a high content of hydrogen in the α- and β-positions to the aromatic ring, 29 % and 34 % respectively, which indicates a large number of alkyl substituents in the aromatic rings and near double bonds. The total amount of aliphatic and aromatic hydrogen in the tar is 79 % and 21 % respectively. Olefinic hydrogen is presented in the initial tar in an amount of 8 %. It is possible to make a choice of techniques for further processing (hydrogenation, coking, thermal cracking) to obtain products with high added value on the basis of determination of the elemental composition, quantitative distribution of hydrogen in the primary coke oven tar and its fractions by the using of above mentioned physical and chemical methods.
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14.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Borodina O., Makarov G., Masunov A. E., Bartashevich E., Ovchinnikova I. G., Titova Y. A., Fedorova O., Yeltsov O.
Заглавие : Pseudocyclic form of 4-hydroxypyrrolidine-2-carboxanilide podands with trioxyethylene chain: modeling, conformational search, and nmr analysis
Место публикации : The journal of physical chemistrY A (Dynamics, kinetics, environmental chemistry, spectroscopy, structure, theory). - 2021. - Vol. 125, № 28. - С. 6029-6041
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The 4-hydroxypyrrolidine-2-carboxanilide podand salt demonstrates catalytic activity in asymmetric Biginelli reaction. The systematic search for prevalent conformational state of the cation was carried out by computer simulations in combination with one- and two-dimensional NMR experiments. For that purpose, we proposed a novel algorithm for the generation and selection of conformers based on molecular dynamics and clustering in the space of principal components. The search had found an important trend of the podand to form a pseudocyclic structure with a horseshoe-shaped conformation of the oligooxyethylene fragment. This conformation is stabilized by different types of intramolecular hydrogen bonds between the acidic and basic centers of the two 4-hydroxypyrrolidine-2-carboxanilide residuals (branches). The proposed approach had made it possible to identify the major structural factors, providing a correlation between the calculated and experimental chemical shifts of hydrogen atoms in the 1H NMR spectra of the protonated podand.
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15.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Smyshliaeva L. A., Varaksin M. V., Fomina E. I., Medvedeva M. V., Svalova T. S., Kozitsina A. N., Charushin V. N., Chupakhin O. N., Demidov O. P., Borovlev I. V., Mensch C., Mampuys P., Maes B. U. W.
Заглавие : 1,3,7-triazapyrene-based ortho-carborane fluorophores: convenient synthesis, theoretical studies, and aggregation-induced emission properties
Место публикации : Organometallics. - 2021. - Vol. 40, № 16. - С. 2792-2807
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: A convenient transition-metal-free approach, based on nucleophilic substitution of hydrogen (SNH), for consecutive regioselective C–H functionalization of 1,3,7-triazapyrene scaffolds with carboranyllithium and phenyllithium is reported. The theoretical calculations disclosed highlight key features in the regioselectivity and mechanism of the investigated SNH transformations. The novel 1,3,7-triazapyrene-based ortho-carboranes obtained have large potential in the field of molecular electronics as organic luminophores, which are characterized by the aggregation-induced emission and dual-emission effects.
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16.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Moseev T. D., Nikiforov E. A., Varaksin M. V., Starnovskaya E. S., Savchuk M. I., Nikonov I. L., Kopchuk D. S., Zyryanov G. V., Chupakhin O. N., Charushin V. N.
Заглавие : Novel pentafluorophenyl- and alkoxyphenyl-appended 2,2'-bipyridine push-pull fluorophores: a convenient synthesis and photophysical studies
Место публикации : Synthesis. - 2021. - Vol. 53, № 19. - С. 3597-3607
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): 2,2′-bipyridines--1,2,4-triazines--polyfluoroarenes
Аннотация: A convenient method for the synthesis of new highly in non-polar solvents soluble photoactive pentafluorophenyl-substituted and extended alkoxyphenyl-substituted 2,2′-bipyridines is reported. The synthetic strategy for the preparation of such ligands involves a sequence of several structural transformations, such as O-alkylation, nucleophilic substitution of hydrogen (SN H) in 1,2,4-triazine precursors via the ‘addition–elimination’ scheme, and the subsequent conversion of the obtained 1,2,4-triazines into 2,2′-bipyridines by means of the aza-Diels–Alder reaction. The photophysical properties of the synthesized novel pentafluoroaryl-substituted 2,2′-bipyridines were comprehensively studied. The obtained photophysical data indicate the competitive advantages of the herein reported pentafluoroarylated push–pull fluorophores, bearing extended aliphatic moieties, over their analogues containing benzoxy or phenolic fragments in terms of improvement in quantum yield and well-pronounced positive solvatochromism confirmed by the mathematical analysis according to the Lippert–Mataga equation.
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17.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Charushin V. N., Titova Y. A., Milaeva E. R.
Заглавие : Chemical elements in medicine
Место публикации : Herald of the Russian academy of sciences. - 2020. - Vol. 90, № 2. - С. 229-238
Ключевые слова (''Своб.индексиров.''): beta-lactam antibiotics--boron neutron capture therapy--fluoroquinolones--heterocycles
Аннотация: A brief review of chemical elements, compounds from which find application in medicine, ranging from the commonly occurring organogenic elements (carbon, hydrogen, nitrogen, oxygen, sulfur, and phosphorus), composing the structure of proteins and nucleic acids of the cells of living organisms and determining the genetic transmission, to native rarely encountered organic fluorine compounds, synthetic derivatives of which have become firmly ingrained in the arsenal of modern pharmaceutical drugs, is given. Strong emphasis is put on metalloproteins, which play a significant role in the biochemistry of vitally essential processes, as well as metal compounds that are widely used in medicine. Of particular importance are the chemical elements and the isotopes, compounds of which are employed in nuclear medicine for diagnostics and treatment of a wide range of diseases, oncological and cardiovascular in particular.
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18.

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Moseev T. D., Varaksin M. V., Virlova E. A., Chupakhin O. N., Charushin V. N.
Заглавие : Direct c-li/c-h coupling of c6f5li with azines and azoles n-oxides as efficient approach toward to polyfloorinated azaheterocycles
Место публикации : Actual problems of organic chemistry and biotechnology. - Екатеринбург, 2020. - С. 276-277
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): c-c coupling--nucleophilic substitution of hydrogen--fluorine--fluorarenes
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19.

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Moseev T. D., Varaksin M. V., Lavrinchenko I. A., Chupakhin O. N., Charushin V. N.
Заглавие : Synthesis of meso-substituted calix[4]arenes via reaction of nucleophilic substitution of hydrogen (snh) in azine or azine-n-oxides
Место публикации : Actual problems of organic chemistry and biotechnology. - Екатеринбург, 2020. - С. 273-274
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): calix[4]arenes--azines--c-c coupling--nucleophilic substitution of hydrogen
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20.

Вид документа : Статья из журнала
Шифр издания : 54/S 98
Автор(ы) : Verbitskiy E. V., Baskakova S. A., Pervova M. G., Rusinov G. L., Chupakhin O. N., Charushin V. N., Gerasimova N. A., Evstigneeva N. P., Zil'berberg N. V., Kungurov N. V., Kravchenko M. A., Skornyakov S. N.
Заглавие : Synthesis and biological evaluation of novel 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines as potential anti-bacterial agents
Место публикации : Bioorganic and Medicinal Chemistry Letters. - 2017. - Vol. 27, № 13. - С. 3003-3006
ББК : 54
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): pyrimidine--nitrofuran--antigonorrheal--antimycobacterial--nucleophilic aromatic substitution of hydrogen
Аннотация: A facile two-step synthetic approach to fluorinated and non-fluorinated 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines from readily available 5-bromo-4-(furan-2-yl)pyrimidine has been developed. All synthesized compounds were screened in vitro for their antibacterial activities against twelve various bacterial strains. It is demonstrated that some of these compounds exhibited significant antibacterial activities against strains Neisseria gonorrhoeae and Staphylococcus aureus, comparable and even higher with that commercial drug Spectinomycin.
\\\\Expert2\\NBO\\Bioorganic and Medicinal Chemistry Letters\\2017 v.27 p.3003-3006.pdf
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