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1.
Инвентарный номер: нет.
   
   U 52


   
    Unexpected formation of diethyl 2-ethoxy-6-CF.sub.3-2H-pyran-3,5-dicarboxylate from the condensation of ethyl 4,4,4-trifluoroacetoacetate with CH(OEt).sub.3 / Y. S. Kudyakova, D. N. Bazhin, P. A. Slepukhin, Ya. V. Burgart, V. I. Saloutin, V. N. Charushin // Tetrahedron Letters. - 2017. - Vol. 58, № 8. - P744-747
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRAN -- DETRIFLUOROACETYLATION -- ETHYL TRIFLUOROACETOACETATE -- CONDENSATION -- PYRIDINES
Аннотация: The one-step preparation of diethyl 2-ethoxy-6-CF3-2H-pyran-3,5-dicarboxylate via the condensation of ethyl 4,4,4-trifluoroacetoacetate with CH(OEt)3 has been reported and a plausible mechanism for this transformation is discussed. To demonstrate the synthetic potential of the obtained pyran, the reactions with ammonia and aromatic amines to give trifluoromethylated pyridine derivatives are presented.

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2.
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    The electrochemical behavior’s character of a potential antiviral drug 3-nitro-4-hydroxy-7-methylthio-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazinide monohydrate / P. N. Mozharovskaia, A. V. Ivoilova, R. A. Drokin [и др.] // Chimica Techno Acta. - 2022. - Vol. 9, № 4. - Ст. 20229426
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
NITROHETEROCYCLIC COMPOUNDS -- ANTIVIRAL ACTIVITY -- CYCLIC VOLTAMMETRY
Аннотация: The results of this study of the electrochemical transformation of 3-R-4-hydroxy-1,4-dihydro-7-X-1,2,4-triazolo[5,1-c][1,2,4] obtained by voltammetry are presented. It was found that 3-R-4-hydroxy-1,4-dihydro-7-X-1,2,4-triazolo[5,1-c][1,2,4] derivatives are capable of electrochemical reduction in the potential range of -0.28 to -0.33 V (relative to Ag/AgCl) in Britton-Robinson buffer at pH = 2. The electrochemical behavior of the sodium salt of 3-nitro-4-hydroxy-7-methylthio-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazinide monohydrate (compound 1), which in silico modeling predicted possible biological activity against various tick-borne encephalitis and Coxsackie B3 viruses. At the potentials of the first stage of electroreduction at pH = 2, the main transformation process is the three-electron reduction scheme of the nitro group of compound 1. It was established that compound 1 in an aprotic medium is reduced in ionic form, most likely in the form of an ion pair with the Na+ cation, and in an aqueous medium in the form of a protonated particle. Based on this, a scheme was proposed for the probable electrochemical transformation of the studied compound.

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3.
Инвентарный номер: нет.
   
   S 98


   
    Synthesis, structure and redox properties of new cobalt(II) and nickel(II) complexes with 6-ferrocenyl-2,2?-bipyridyl [Text] / A. Golberg, M. Kiskin, V. Grinberg, S. Kozyukhin, A. S. Bogomyakov, I. A. Utepova, A. A. Sidorov, O. N. Chupakhin, I. L. Eremenko // Journal of Organometallic Chemistry. - 2011. - Vol. 696, № 13. - P2607-2610. - Bibliogr. : p. 2610 (17 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: New ionic complexes [ML2(MeCN)2]•2Otf (M = Co or Ni; L = 6-ferrocenyl-2,2?-bipyridyl) were synthesized and characterized by single-crystal X-ray diffraction. Cyclic voltammograms of the compounds [ML2(MeCN)2]•2Otf in CH2Cl2 show good cycle stability over 100 cycles in the quasi-reversible oxidation potential range (from 0.25 to 0.5 V).????

\\\\Expert2\\nbo\\Journal of Organometallic Chemistry\\2011, v.696, p.2607.pdf
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4.
Инвентарный номер: нет.
   
   S 98


   
    Synthesis of new C(4) and/or C(5) thienyl substituted pyrimidines as potential antimycobacterial agents. / E. V. Verbitskiy, E. M. Cheprakova, M. A. Kravchenko, S. N. Skornyakov, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // 19h European Symposium on Organic Chemistry (ESOC-2015), 12th-16th July, Lisboa, Portugal, 2015. : book of abstr. . - Lisboa, 2015. - С. 450
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINES -- ANTIMYCOBACTERIAL AGENTS -- SYNTHESIS

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5.
Инвентарный номер: нет.
   
   K 81


    Krasnov, V. P.
    Synthesis and properties of 1-aminocyclopropane-1,2-dicarboxylic acid and compounds incorporating it [Electronic resource] / V. P. Krasnov, M. A. Koroleva, G. L. Levit // Russian Chemical Reviews. - 2003. - Vol. , № 4. - P343-356
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: Methods for the synthesis of 1-aminocyclopropane-1,2-dicarboxylic acid derivatives including carbo- and heterocyclic compounds and peptides are analysed. Special attention is given to methods for the synthesis of individual stereoisomers of 1-aminocyclopropane-1,2-dicarboxylic acid derivatives based on the use of diastereoselective processes or enantiomerically pure starting compounds. The transformations of 1-aminocyclopropane-1,2-dicarboxylic acid derivatives which yield compounds with potential biological activities are considered

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6.
Инвентарный номер: нет.
   
   S 98


   
    Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c][1,2,4]-triazines and Pyrazolo[5,1-c][1,2,4]triazines as Potential Antidiabetic Agents / V. L. Rusinov, I. M. Sapozhnikova, A. M. Bliznik, O. N. Chupakhin, V. N. Charushin, A. A. Spasov, P. M. Vassiliev, V. A. Kuznetsova, A. I. Rashchenko, D. A. Babkov // Archiv der Pharmazie. - 2017. - Vol. 350, № 5. - Pe1600361-[1]-e1600361-[15]
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIDIABETIC AGENTS -- ANTIGLYCATION -- AZOLOTRIAZINES -- CROSS-LINK BREAKERS -- DIABETES MELLITUS -- DIPEPTIDYL PEPTIDASE-4 INHIBITORS
Аннотация: Inhibition of the dipeptidyl peptidase-4 (DPP4) enzyme activity and prevention of advanced glycation end (AGE) products formation represents a reliable approach to achieve control over hyperglycemia and the associated pathogenesis of diabetic vascular complications. In the frames of this research study, several triazolo- and pyrazolotriazines were synthesized and evaluated as inhibitors of AGE products formation, DPP4, glycogen phosphorylase and α-glucosidase activities, as well as AGE cross-link breakers. From the two considered classes of heterocyclic compounds, the pyrazolotriazines showed the highest potency as antiglycating agents and DPP4 inhibitors. Structure–activity relationships (SAR) for these compounds, which can be considered as potential drugs for the treatment of type 2 diabetes, were evaluated.

\\\\Expert2\\NBO\\Archiv der Pharmazie\\2017 V 350 P.pdf
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7.
Инвентарный номер: нет.
   
   S 98


   
    Synthesis and Crystal Structure of (S)-2-((S)-2-(N-Ts-Amino)-3-methylbutanoyl)-3-(1H-indol-3-yl)-6-phenyl-3,4-dihydro-1,2,4-triazin-5(2H)-one [Electronic resource] / I. N. Egorov, V. L. Rusinov, P. A. Slepukhin, O. N. Chupakhin // Journal of Chemical Crystallography . - 2010. - Vol. 40, № 4. - P387-390
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The diastereoselective synthesis, NMR and X-ray structure of (S)-2-((S)-2-(N-Ts-amino)-3-methylbutanoyl)-3-(1H-indol-3-yl)-6-phenyl-3,4-dihydro-1,2,4-triazin-5(2H)-one—a potential antivirus agent are reported. The compound crystallizes in the triclinic space group P1 with unit cell parameters: a = 5.9259(6) A, b = 9.6370(12) A, c = 12.9541(9) A, = 109.210(9)°, beta = 90.804(7)°, y = 105.074(10)° and Z = 1.

\\\\Expert2\\nbo\\Journal of Chemical Crystallography\\2010.v.40, N 4, p.387.pdf
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8.
Инвентарный номер: нет.
   


   
    Synthesis and characterization of linear 1,4-diazine-triphenylamine–based selective chemosensors for recognition of nitroaromatic compounds and aliphatic amines / E. V. Verbitskiy, Y. A. Kvashnin, E. F. Zhilina [et al.] // Dyes and pigments. - 2020. - Vol. 178. - P108344
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ALIPHATIC AMINES -- FLUORESCENCE QUENCHING -- NITROAROMATIC COMPOUNDS -- PYRAZINE -- QUINOXALINE -- SOLVATOCHROMISM
Аннотация: Novel 1,4-diazine-based dyes of the D–π–A type, possessing triphenylamine as an electron-donating group, have been developed. Fluorescence studies have demonstrated that emission of these fluorophores is sensitive towards different nitroaromatic compounds and aliphatic amines, both in solutions and in a vapor phase. Moreover, these compounds can be considered as “naked-eye” fluorescent probes for solution polarity because they possess pronounced solvatochromic properties. Therefore, these compounds have to be regarded as potential multifunctional chemosensors for monitoring hazardous organic substances.

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9.
Инвентарный номер: нет.
   
   S 98


   
    Synthesis and biological evaluation of novel 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines as potential anti-bacterial agents / E. V. Verbitskiy [et al.] // Bioorganic and Medicinal Chemistry Letters. - 2017. - Vol. 27, № 13. - P3003-3006
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINE -- NITROFURAN -- ANTIGONORRHEAL -- ANTIMYCOBACTERIAL -- NUCLEOPHILIC AROMATIC SUBSTITUTION OF HYDROGEN
Аннотация: A facile two-step synthetic approach to fluorinated and non-fluorinated 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines from readily available 5-bromo-4-(furan-2-yl)pyrimidine has been developed. All synthesized compounds were screened in vitro for their antibacterial activities against twelve various bacterial strains. It is demonstrated that some of these compounds exhibited significant antibacterial activities against strains Neisseria gonorrhoeae and Staphylococcus aureus, comparable and even higher with that commercial drug Spectinomycin.

\\\\Expert2\\NBO\\Bioorganic and Medicinal Chemistry Letters\\2017 v.27 p.3003-3006.pdf
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10.
Инвентарный номер: нет.
   


   
    Study of different carbonaceous materials as modifiers of screen-printed carbon electrodes for the triazid as potential antiviral drug / A. V. Ivoilova, N. A. Malakhova, P. N. Mozharovskaia [et al.] // Electroanalysis. - 2022. - Vol. 34, № 11. - P1745-1755
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: In this work a comparative study of Screen-Printed Carbon Electrodes (SPCE) – bare and modified by drop casting with carbonaceous nanomaterials (CNMs) as Multi Walled Carbon Nanotubes (MWCNT), Carbon Black and Functionalized Carbon Black for voltammetric determination of 5-methyl-6-nitro-7-oxo-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidinide l-arginine monohydrate (Triazid) as a potential drug with a broad spectrum of antiviral activity is reported. Bare SPCE and CNMs modified SPCE (SPCE/CNMs) have been characterized morphologically by SEM and electrochemically by cyclic voltammetry/electrochemical impedance spectroscopy with [Fe(CN)6]4−/3− as redox probe. Significant improvement of electrochemical performances is achieved with SPCE/CNMs compared with the bare SPCE. Among SPCE/CNMs studied SPCE modified with MWCNT (SPCE/CNT) is characterized by the best combination of electrochemical properties and electroanalytical performance towards TD. The linear dynamic range is 25–200 mg L−1 (R2=0.9975) with the limit of detection – 2.8 mg L−1 Triazid using SPCE/CNT and Square-Wave Voltammetry technique. The developed sensor was successfully used for Triazid determination in the Pharmaceutical Substance “TRIAZID”. The results achieved with SPCE/CNMs after chemical binding of dissolved oxygen in 0.04 M Britton-Robinson buffer+0.04 M Na2SO3 (pH 7.2±0.2) are very useful for further development of cost-effective and time-consuming pharmaceutical routine assay.

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