Главная Новые поступления Описание Шлюз Z39.50

Базы данных


Труды сотрудников Института органического синтеза УрО РАН - результаты поиска

Вид поиска

Область поиска
 Найдено в других БД:Публикации Черешнева В.А. (1)Публикации Чарушина В.Н. (5)
Формат представления найденных документов:
полныйинформационныйкраткий
Отсортировать найденные документы по:
авторузаглавиюгоду изданиятипу документа
Поисковый запрос: (<.>K=EFFICACY<.>)
Общее количество найденных документов : 7
Показаны документы с 1 по 7
1.
Инвентарный номер: нет.
   
   T 44


   
    Лечебная эффективность нового отечественного химиопрепарата Триазавирин в отношении возбудителя гриппа А (H5N1) = Therapeutic efficacy of triazavirin, a novel russian chemotherapeutic, against influenza virus A (H5N1) / S. A. Loginova, S. V. Borisevich, V. A. Maksimov, V. P. Bondarev, S. K. Kotovskaya, V. L. Rusinov, V. N. Charushin, O. N. Chupakhin // Антибиотики и химиотерапия. - 2011. - Т. 56, № 1-2. - С. 10-12. - Библиогр.: с. 12 (13 назв.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ТРИАЗАВИРИН -- ВИРУС ГРИППА A

Найти похожие

2.
Инвентарный номер: нет.
   
   A 10


   
    A new antiviral drug triazavirin: Results of phase II clinical trial [Электронный ресурс] / O. I. Kiselev, E. G. Deyeva, T. I. Melnicova, K. N. Kozeletskaia, A. S. Klselev, V. L. Rusinov, V. N. Charushin, O. N. Chupakhin // Voprosy Virusologii . - 2012. - Vol.57, №6. - P9-12
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
CLINICAL TRIAL -- EFFICACY -- INFLUENZA
Аннотация: The results of the clinical trial testing the efficacy of a new anti-influenza drug Triazavirin are presented in this work. The data of the trial were gathered during the 2010 influenza season. The treatment with oral Triazavirin significantly reduced the duration of the main clinical symptoms of influenza (intoxication, fever, respiratory symptoms), decreased the incidence of the influenza-related complications and the use of symptomatic drugs. The re-isolation rate of the influenza A and B viruses was significantly lower in the patients who were using Triazavirin. The analysis of the clinical data showed that the optimal prescribed dosage was 250 mg 3 times a day. -------------------------------------------------------------------------------- Reaxys Database Information|

Найти похожие

3.
Инвентарный номер: нет.
   
   T 86


   
    Triazaverin prophylactic efficacy against influenza virus A (H5N1) [Электронный ресурс] / S. Ya. Loginova, S. V. Borisevich, B. A. Maksimov, V. P. Bondarev, S. K. Kotovskaya, V. L. Rusinov, V. N. Charushin, O. N. Chupakhin // Antibiotiki i Khimioterapiya . - 2010. - Vol.55, №9-10. - P25-28
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRAL EFFICACY -- INFLUENZA VIRUS A -- PROPHYLAXIS
Аннотация: The experimental study of the prophylactic efficacy of Triazaverin against the experimental form of the influenza virus A (H5N1) on albino mice intranasally infected with the influenza virus A/Chicken/Kurgan/Russia/02/05 vs. the reference drugs Tamiflu ®, Remantadin and Arbidol ® showed that in doses of 1 to 100 mg/kg it was efficient in the animal protection from death. The drug was also efficient in the urgent prophylaxis. Triazaverin effectively inhibited the influenza A virus multiplication in the lungs of the albino mice

Найти похожие

4.
Инвентарный номер: нет.
   
   I-70


   
    Investigation of triazavirin antiviral activity against influenza A virus (H5N1) in cell culture [Электронный ресурс] / S. Ya. Loginova, S. V. Borisevich, V. A. Maksimov, V. P. Bondarev, S. K. Kotovskaya, V. L. Rusinov, V. N. Charushin // Antibiotiki i Khimioterapiya . - 2007. - Vol.52, №11-12. - P18-20
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRAL ACTIVITY -- ARBIDOL -- INFLUENZA
Аннотация: Analysis of triazavirin efficacy with respect to influenza A virus (H5N1) in sensitive cell culture MDSK vs. effective antigrippe drugs, such as tamiflu, remantadin and arbidol showed that triazavirin in a wide range of the concentrations was efficient in inhibition of the virus cytopathic activity and formation of the specific hemagglutinin

Найти похожие

5.
Инвентарный номер: нет.
   
   O-57


   
    One-Pot, Three-Component Synthesis of Novel Pyrroloacridinones via Intramolecular ipso Dearomatization–Intramolecular Aza-Michael Addition Sequence [Electronic resource] / Y. S. Rozhkova, K. A. Galata, A. A. Gorbunov, Yu. V. Shklyaev, M. A. Ezhikova, M. I. Kodess // Synlett. - 2014. - Vol. 25, № 18. - С. 2617-2623
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
INTRAMOLECULAR IPSO DEAROMATIZATION -- SPIRO-SUBSTITUTED CYCLOHEXA-2,5-DIENONE -- DOMINO REACTION
Аннотация: A one-pot, three-component synthesis of novel pyrroloacridinones from a set of alkoxy arenes and 2,6-dialkylphenols, isobutyric aldehyde, and 2-aminobenzonitrile is described. We have demonstrated the efficacy of the combination of intramolecular electrophilic ipso dearomatization of suitable aromatic compounds leading to spiro-substituted cyclohexa-2,5-dienones and intramolecular aza-Michael addition for the preparation of complex aza-heterocyclic systems.

\\\\expert2\\nbo\\Synlett\\2014, V.25, p. 2617.pdf
Найти похожие

6.
Инвентарный номер: нет.
   


   
    Synthesis and approbation of new neuroprotective chemicals of pyrrolyl- and indolylazine classes in a cell model of Alzheimer's disease / E. A. Dutysheva, I. A. Utepova, M. A. Trestsova [et al.] // European journal of medicinal chemistry. - 2021. - Vol. 222. - P113577
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRROLYLAZINES -- NEUROPROTECTORS -- CHAPERONES -- AMYLOID-BETA -- ALZHEIMER'S DISEASE
Аннотация: One of the major causes of neurodegeneration in the pathogenesis of Alzheimer's disease is the accumulation of cytotoxic amyloid species within the intercellular compartments of the brain. The efficacy of the anti-proteotoxic mechanism based on the molecular chaperones Hsp70 and Hsp90 in numerous types of neurons is often low, while its pharmacological enhancement has been shown to ameliorate the physiological and cognitive functions of the brain. Suggesting that the chemicals able to induce heat shock protein synthesis and therefore rescue neural cells from cytotoxicity associated with amyloid, we have synthesized a group of pyrrolyl- and indolylazines that cause the accumulation of heat shock proteins, using a novel method of photocatalysis that is employed in green chemistry. The selected compounds were tested in a cell model of Alzheimer's disease and demonstrated a pronounced neuroprotective effect. These substances increased the survival of neurons, blocked the activation of β-galactosidase, and prevented apoptosis in neurons cultured in the presence of β-amyloid.

Найти похожие

7.
Инвентарный номер: нет.
   


   
    Combined in silico, ex vivo, and in vivo assessment of L-17, a thiadiazine derivative with putative neuro-and cardioprotective and antidepressant effects / A. Sarapultsev, P. M. Vassiliev, D. M. Grinchii [et al.] // International journal of molecular sciences. - 2021. - Vol. 22, № 24. - P13626
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
TREATMENT-RESISTANT DEPRESSION -- POST-STROKE DEPRESSION -- C-FOS IMMUNOHISTOCHEMISTRY -- BINDING AFFINITY
Аннотация: Depression associated with poor general medical condition, such as post-stroke (PSD) or post-myocardial infarction (PMID) depression, is characterized by resistance to classical antidepressants. Special treatment strategies should thus be developed for these conditions. Our study aims to investigate the mechanism of action of 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine, hydrobromide (L-17), a recently designed thiadiazine derivative with putative neuro- and cardioprotective and antidepressant-like effects, using combined in silico (for prediction of the molecular binding mechanisms), ex vivo (for assessment of the neural excitability using c-Fos immunocytochemistry), and in vivo (for direct examination of the neuronal excitability) methodological approaches. We found that the predicted binding affinities of L-17 to serotonin (5-HT) transporter (SERT) and 5-HT3 and 5-HT1A receptors are compatible with selective 5-HT serotonin reuptake inhibitors (SSRIs) and antagonists of 5-HT3 and 5-HT1A receptors, respectively. L-17 robustly increased c-Fos immunoreactivity in the amygdala and decreased it in the hippocampus. L-17 dose-dependently inhibited 5-HT neurons of the dorsal raphe nucleus; this inhibition was partially reversed by the 5-HT1A antagonist WAY100135. We suggest that L-17 is a potent 5-HT reuptake inhibitor and partial antagonist of 5-HT3 and 5-HT1A receptors; the effects of L-17 on amygdaloid and hippocampal excitability might be mediated via 5-HT, and putatively mediate the antidepressant-like effects of this drug. Since L-17 also possesses neuro- and cardioprotective properties, it can be beneficial in PSD and PMID. Combined in silico predictions with ex vivo neurochemical and in vivo electrophysiological assessments might be a useful strategy for early assessment of the efficacy and neural mechanism of action of novel CNS drugs.

Найти похожие

 

Сиглы отделов ЦНБ УрО РАН


  бр.ф. - Бронированный фонд

  бф - Научно-библиографический отдел

  БХЛ - Фонд художественной литературы

  ИИиА -Фонд исторической литературы в ЦНБ УрО РАН

  ИМЕТ -Отдел ЦНБ в Институте металлургии УрО РАН

  кх - Отдел фондов (книгохранениe)

  МБА - Межбиблиотечный абонемент

  мф - Методический фонд

  ок - Отдел научной каталогизации

  оку - Отдел комплектования и учета

  орф - Обменно-резервный фонд

  пф - Читальный зал деловой и патентной информации

  рк - Фонд редкой книги

  ч/з - Главный читальный зал

  эр - Зал электронных ресурсов

  

Сиглы библиотек институтов и НЦ УрО РАН
© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)
Яндекс.Метрика