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Каталог книг и продолжающихся изданий
Сводный каталог иностранных периодических изданий, имеющихся в библиотеках УрО РАН
Сводный каталог отечественных периодических изданий, имеющихся в библиотеках УрО РАН
Каталог диссертаций и авторефератов диссертаций УрО РАН
Каталог препринтов УрО РАН (1975 г. - )
Имидж-каталог отечественных книг (до 2010 г.)
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Алфавитно-предметный указатель (АПУ) ЦНБ УрО РАН
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Изобретения уральских ученых
Интеллектуальная собственность (статьи из периодики)
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Демидовские премии
Гибель династии Романовых
История Урала
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Книжная коллекция Шубиных
Труды Института высокотемпературной электрохимии УрО РАН
Труды Института истории и археологии УрО РАН
Труды сотрудников Института горного дела УрО РАН
Труды сотрудников Института органического синтеза УрО РАН
Труды сотрудников Института теплофизики УрО РАН
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Труды сотрудников ЦНБ УрО РАН
Публикации Черешнева В.А.
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Каталог библиотеки ИЭРиЖ УрО РАН
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1.
Инвентарный номер: нет.
   
   S 43

   
    Secondary structure of the M2 protein of type-A influenza-virus and its role in rimantadine and deytiforine resistanse [Text] / O. I. Kiselev, V. P. Mishin, V. I. Eroshkin, K. N. Kizeletskaya, E. V. Usova, V. I. Rudenko, O. N. Chupakhin // Molecular Biology. - 1994. - Vol. 28, N 5. - P650-653
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: Studies on the molecular aspects of resistance of influenza virus A to drugs (rimantadine, deytiforine, amantadine) allow purposeful design of new compounds having a broad spectrum of antiviral activity and evoking no resistance

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2.
Инвентарный номер: нет.
   
   L 62

    Levit, G. L.
    Synthesis of Amides of Nonsteroidal Anti-Inflammatory Drugs with Potentially Low Gastrotoxicity [Text] : доклад, тезисы доклада / G. L. Levit, M. A. Koroleva, V. P. Krasnov // International Memorial I.Postovsky Conference on Organic Chemisty, Ekaterinburg, March 17-20, 1998 : program and abstracts. - Ekaterinburg, 1998. - P91
ББК 61 + 5
Рубрики: ХИМИЧЕСКИЕ НАУКИ
   ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ

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3.
Инвентарный номер: нет.
   
   N 52

   
    New method for the annelation of the pyridine fragment to azines [Electronic resource] / V. N. Charushin, A. M. Boguslavskii, M. G. Ponizovskii, M. I. Kodess, A. N. Chekhlov, Sh. G. Mkoyan, S. M. Aldoshin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2004. - Vol. 53, № 6. - P1267-1271
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The reaction of quinoxaline-2-carbaldehyde with ethyl (E)-3-aminocrotonate afforded ethyl 4-oxo-1,4-dihydropyrido[2,3-b]quinoxaline-3-carboxylate, which is a structural analog of nalidixic and 4-quinolone-3-carboxylic acids representing the basis of the known antibacterial drugs of the fluoroquinolone series

\\\\Expert2\\nbo\\Russian Chemical Bulletin\\2004, 53 (6), 1267.pdf
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4.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis of acyclic nucleosides based on 1,2,4-triazolo[3,2-c][1,2,4]triazin-7-ones [Electronic resource] / T. S. Shestakova, L. S. Lukyanova, T. A. Tseitler, S. L. Deev, E. N. Ulomskii, V. L. Rusinov, M. I. Kodess, O. N. Chupakhin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2008. - Vol. 57, № 11. - P2423-2430
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: A new class of acyclic nucleosides based on 6-phenyl-1,2,4-triazolo[3,2-c][1,2,4]triazin-7-ones was synthesized and structurally characterized for the first time

\\\\Expert2\\nbo\\Russian Chemical Bulletin\\2008, 57 (11), 2423.pdf
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5.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis and antiviral activity of nucleoside analogs based on 1,2,4-triazolo[3,2-c][1,2,4]triazin-7-ones [Electronic resource] / V. L. Rusinov, O. N. Chupakhin, S. L. Deev, T. S. Shestakova, E. N. Ulomskii, L. I. Rusinova, O. I. Kiselev, E. G. Deeva // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2010. - Vol. 59, № 1. - P136-143
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
NUCLEOSIDE ANALOGS -- ANTIVIRAL DRUGS -- HYDROXYETHOXYMETHYL
Аннотация: Nucleoside analogs containing hydroxybutyl, hydroxyethoxymethyl, allyloxymethyl, and propargyloxymethyl fragments were synthesized based on 1,2,4-triazolo[3,2-c][1,2,4]triazin-7-ones isosteric to purine bases. Some of the compounds obtained inhibit in vitro reproduction of influenza and respiratory syncytial virus infection

\\\\Expert2\\nbo\\Russian Chemical Bulletin\\2010, 59 (1), 136-143.pdf
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6.
Инвентарный номер: нет.
   
   A 62

   
    Antiviral Properties, Metabolism, and Pharmacokinetics of a Novel Azolo-1,2,4-Triazine-Derived Inhibitor of Influenza A and B Virus Replication [Text] / I. L. Karpenko, S. L. Deev, O. I. Kiselev, V. N. Charushin, V. L. Rusinov, E. N. Ulomskii, E. G. Deeva, O. N. Chupakhin // Antimicrobial Agents and Chemotherapy. - 2010. - Vol. 54, № 5. - P2017-2022
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: Influenza viruses of types A and B cause periodic pandemics in the human population. The antiviral drugs approved to combat influenza virus infections are currently limited. We have investigated an effective novel inhibitor of human influenza A and B viruses, triazavirine {2-methylthio-6-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazine-7(4I)-one} (TZV). TZV suppressed the replication of influenza virus in cell culture and in chicken chorioallantoic membranes, and it protected mice from death caused by type A and B influenza viruses. TZV was also effective against a rimantadine-resistant influenza virus strain and against avian influenza A virus H5N1 strains. The pharmacokinetic parameters and bioavailability of TZV were calculated after the administration of TZV to rabbits. The TZV metabolite AMTZV {2-methylthio-6-amino-1,2,4-triazolo[5,1-s]-1,2,4-triazin(e)-7(4I)-one} was discovered in IAK 293T and Huh7 cell cultures, a liver homogenate, and rabbit blood after intragastric administration of TZV. AMTZV was nontoxic and inactive as an inhibitor of influenza virus in cell culture. Most likely, this metabolite is a product of TZV elimination

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7.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis and tuberculostatic activity of fluoridized 3-Z-hydrazine-2-benzoyl acrylates and their cyclization products / M. A. Kravchenko, E. V. Nosova, G. N. Lipunova, O. M. Chasovskikh, V. A. Sokolov, V. N. Charushin // Problemy tuberkuleza . - 2003. - №7. - С. 49-52
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ACRYLIC ACID DERIVATIVE -- PYRAZOLE -- TUBERCULOSTATIC AGENT
Аннотация: A rapid development of the resistance of drugs and their toxic and adverse reactions suggest that new antituberculous drugs should be designed. Of the greatest importance is isoniazid resistance. Testing new compounds (IIa, b) has established that the minimum inhibitory concentration of the drug (IIa), 0.39 microgram/ml suppresses the growth of Mycobacterium tuberculosis (MBT) in the macrophages up to 50%, that of the drug (IIb), 1.56 micrograms/ml, causes death in 25% of cases, which is indicative of the high activity of compounds (IIa, b) against MBT

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8.
Инвентарный номер: нет.
   
   C 31

   
    Catalytic effect of nanosized metal oxides on the knoevenagel reaction / Yu. A. Titova, O. V. Fedorova, I. G. Ovchinnikova, G. L. Rusinov, V. N. Charushin // Russian Journal of Applied Chemistry. - 2012. - Vol.85, №4. - С. 656-660
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
CATALYTIC EFFECT -- METAL OXIDES -- KNOEVENAGEL REACTION
Аннотация: The effect of nanosized metal oxides (Al, Mg, Cu, Ni oxides) on the synthesis of chalcones that are key intermediate in the synthesis of Nitrendipine and Felodipine drugs was examined

\\\\Expert2\\nbo\\Russian Journal of Applied Chemistry\\2012, v. 85, N 4, p.656.pdf
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9.
Инвентарный номер: нет.
   
   A 10

   
    A new antiviral drug triazavirin: Results of phase II clinical trial [Электронный ресурс] / O. I. Kiselev, E. G. Deyeva, T. I. Melnicova, K. N. Kozeletskaia, A. S. Klselev, V. L. Rusinov, V. N. Charushin, O. N. Chupakhin // Voprosy Virusologii . - 2012. - Vol.57, №6. - P9-12
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
CLINICAL TRIAL -- EFFICACY -- INFLUENZA
Аннотация: The results of the clinical trial testing the efficacy of a new anti-influenza drug Triazavirin are presented in this work. The data of the trial were gathered during the 2010 influenza season. The treatment with oral Triazavirin significantly reduced the duration of the main clinical symptoms of influenza (intoxication, fever, respiratory symptoms), decreased the incidence of the influenza-related complications and the use of symptomatic drugs. The re-isolation rate of the influenza A and B viruses was significantly lower in the patients who were using Triazavirin. The analysis of the clinical data showed that the optimal prescribed dosage was 250 mg 3 times a day. -------------------------------------------------------------------------------- Reaxys Database Information|

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10.
Инвентарный номер: нет.
   
   T 86

   
    Triazaverin prophylactic efficacy against influenza virus A (H5N1) [Электронный ресурс] / S. Ya. Loginova, S. V. Borisevich, B. A. Maksimov, V. P. Bondarev, S. K. Kotovskaya, V. L. Rusinov, V. N. Charushin, O. N. Chupakhin // Antibiotiki i Khimioterapiya . - 2010. - Vol.55, №9-10. - P25-28
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRAL EFFICACY -- INFLUENZA VIRUS A -- PROPHYLAXIS
Аннотация: The experimental study of the prophylactic efficacy of Triazaverin against the experimental form of the influenza virus A (H5N1) on albino mice intranasally infected with the influenza virus A/Chicken/Kurgan/Russia/02/05 vs. the reference drugs Tamiflu ®, Remantadin and Arbidol ® showed that in doses of 1 to 100 mg/kg it was efficient in the animal protection from death. The drug was also efficient in the urgent prophylaxis. Triazaverin effectively inhibited the influenza A virus multiplication in the lungs of the albino mice

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11.
Инвентарный номер: нет.
   
   A 62

   
    Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication [Электронный ресурс] / I. L. Karpenko, S. L. Deev, O. I. Kiselev, V. N. Charushin, V. L. Rusinov, E. N. Ulomskii, E. G. Deeva, M. K. Kukhanova // Antimicrobial Agents and Chemotherapy . - 2010. - Vol.54, №5. - P2017-2022
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ANIMAL CELL -- ANIMAL EXPERIMENT -- ANTIVIRAL ACTIVITY
Аннотация: Influenza viruses of types A and B cause periodic pandemics in the human population. The antiviral drugs approved to combat influenza virus infections are currently limited. We have investigated an effective novel inhibitor of human influenza A and B viruses, triazavirine {2-methylthio-6-nitro-1,2,4- triazolo[5,1-c]-1,2,4-triazine-7(4Í)-one} (TZV). TZV suppressed the replication of influenza virus in cell culture and in chicken chorioallantoic membranes, and it protected mice from death caused by type A and B influenza viruses. TZV was also effective against a rimantadine-resistant influenza virus strain and against avian influenza A virus H5N1 strains. The pharmacokinetic parameters and bioavailability of TZV were calculated after the administration of TZV to rabbits. The TZV metabolite AMTZV {2-methylthio-6-amino-1,2,4- triazolo[5,1-s]-1,2,4-triazin(e)-7(4Í)-one} was discovered inÍÅK 293T and Huh7 cell cultures, a liver homogenate, and rabbit blood after intragastric administration of TZV. AMTZV was nontoxic and inactive as an inhibitor of influenza virus in cell culture. Most likely, this metabolite is a product of TZV elimination

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12.
Инвентарный номер: нет.
   
   I-70

   
    Investigation of triazavirin antiviral activity against influenza A virus (H5N1) in cell culture [Электронный ресурс] / S. Ya. Loginova, S. V. Borisevich, V. A. Maksimov, V. P. Bondarev, S. K. Kotovskaya, V. L. Rusinov, V. N. Charushin // Antibiotiki i Khimioterapiya . - 2007. - Vol.52, №11-12. - P18-20
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRAL ACTIVITY -- ARBIDOL -- INFLUENZA
Аннотация: Analysis of triazavirin efficacy with respect to influenza A virus (H5N1) in sensitive cell culture MDSK vs. effective antigrippe drugs, such as tamiflu, remantadin and arbidol showed that triazavirin in a wide range of the concentrations was efficient in inhibition of the virus cytopathic activity and formation of the specific hemagglutinin

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13.
Инвентарный номер: нет.
   
   K 81

    Krasnov, V. P.
    Nano-sized melphalan and sarcolysine drug delivery systems: synthesis and prospects of application [Electronic resource] / V. P. Krasnov, M. A. Korolyova, E. L. Vodovozova // Russian Chemical Reviews. - 2013. - Vol.82, №8. - С. 783-814. - Bibliogr. : p. 811-814 (196 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
SARCOLYSINE -- SYNTHESIS -- NANO-SIZED
Аннотация: The results of experimental studies concerned with the development of nano-sized drug delivery systems for the antitumour drugs sarcolysine and melphalan are generalized. The structures and biological activities of nanocarriers in comparison with unmodified drugs are discussed. Particular attention is given to the liposomes containing lipid derivatives of sarcolysine and melphalan in the lipid bilayer

\\\\expert2\\NBO\\Russian Chemical Reviews\\2013, V.82, N8, p.783.pdf
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14.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis and antituberculosis activity of novel 5-styryl-4-(hetero)aryl-pyrimidines via combination of the Pd-catalyzed Suzuki cross-coupling and SNH reactions [Electronic resource] / M. A. Kravchenko, E. V. Verbitskiy, I. D. Medvinskiy, G. L. Rusinov, V. N. Charushin // Bioorganic and Medicinal Chemistry Letters. - 2014. - Vol. 24, №14. - С. 3118-3120
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINE -- ANTIMICOBACTERIAL -- TUBERCULOSIS
Аннотация: Combination of the Suzuki cross-coupling and nucleophilic aromatic substitution of hydrogen (SNH) reactions proved to be a convenient method for the synthesis of 5-styryl-4-(hetero)aryl substituted pyrimidines from commercially available 5-bromopyrimidine. All intermediate 5-bromo-4-(hetero)aryl substituted pyrimidines and also the targeted 5-styryl-4-(hetero)arylpyrimidines were found to be active in micromolar concentrations in vitro against Mycobacterium tuberculosis H37Rv, avium, terrae, and multi-drug-resistant strain isolated from tuberculosis patients in Ural region (Russia). It has been found that some of these compounds possess a low toxicity and have a bacteriostatic effect, comparable and even higher with that of first-line antituberculosis drugs

\\\\expert2\\nbo\\Bioorganic and Medicinal Chemistry Letters\\2014, v. 24, p. 3118.pdf
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15.
Инвентарный номер: нет.
   
   I-55

   
    Immunotropic drugs for local use in stomatology [Electronic resource] / G. I. Ron, I. N. Shtanko, T. G. Khonina, I. A. Tuzankina, A. S. Simbirtsev // Materials of 15th International Congress of Immunology (ICI). - Milan, 2013
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
STOMATOLOGY -- IMMUNOTROPIC DRUGS

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16.
Инвентарный номер: нет.
   
   F 70

   
    Fluorinated analogs of drugs based on salicylates / E. V. Shchegol'kov, I. V. Shchur, Ya. V. Burgart, V. I. Saloutin, O. P. Krasnykh, L. N. Markova, G. N. Seliverstov // X German-Russian-Ukrainian Symposium on Fluorine Chemistry. - Berlin, 2014. - P. 15
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
SALICYLATES -- DRUGS -- FLUORINATED ANALOGS

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17.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis of new bidentate ligands-terpene derivatives of ethylenediamine and their palladium complexes [Electronic resource] / O. A. Gur'eva, I. N. Alekseev, O. A. Zalevskaya, P. A. Slepukhin, A. V. Kutchin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2016. - Vol. 52, № 6. - С. 781-784
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PALLADIUM CHELATES -- DRUGS
Аннотация: New enantiomerically pure Schiff bases and palladium chelates based thereon were synthesized starting from (-)-alpha-pinene or (aEuro')-camphor and N,N-dimethylethane-1,2-diamine.

\\\\expert2\\NBO\\Russian Journal of Organic Chemistry\\2016, 52, (6), 781-784.pdf
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18.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c][1,2,4]-triazines and Pyrazolo[5,1-c][1,2,4]triazines as Potential Antidiabetic Agents / V. L. Rusinov, I. M. Sapozhnikova, A. M. Bliznik, O. N. Chupakhin, V. N. Charushin, A. A. Spasov, P. M. Vassiliev, V. A. Kuznetsova, A. I. Rashchenko, D. A. Babkov // Archiv der Pharmazie. - 2017. - Vol. 350, № 5. - Pe1600361-[1]-e1600361-[15]
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIDIABETIC AGENTS -- ANTIGLYCATION -- AZOLOTRIAZINES -- CROSS-LINK BREAKERS -- DIABETES MELLITUS -- DIPEPTIDYL PEPTIDASE-4 INHIBITORS
Аннотация: Inhibition of the dipeptidyl peptidase-4 (DPP4) enzyme activity and prevention of advanced glycation end (AGE) products formation represents a reliable approach to achieve control over hyperglycemia and the associated pathogenesis of diabetic vascular complications. In the frames of this research study, several triazolo- and pyrazolotriazines were synthesized and evaluated as inhibitors of AGE products formation, DPP4, glycogen phosphorylase and α-glucosidase activities, as well as AGE cross-link breakers. From the two considered classes of heterocyclic compounds, the pyrazolotriazines showed the highest potency as antiglycating agents and DPP4 inhibitors. Structure–activity relationships (SAR) for these compounds, which can be considered as potential drugs for the treatment of type 2 diabetes, were evaluated.

\\\\Expert2\\NBO\\Archiv der Pharmazie\\2017 V 350 P.pdf
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19.
Инвентарный номер: нет.
   
   R 95

    Rusinov, V. L.
    Scientific basis for development of antiviral drugs / V. L. Rusinov, O. N. Chupakhin, V. N. Charushin // Experimental and Computational Biomedicine. Russian Conference with International Participation in memory of Professor Vladimir S. Markhasin: Abstract book. - 2016. - P13
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ

\\\\Expert2\\NBO\\статьи из сборников\\Experimental and Computational Biomedicine 2016. - P. 13.pdf
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20.
Инвентарный номер: нет.
   

    Charushin, V. N.
    Chemical elements in medicine / V. N. Charushin, Y. A. Titova, E. R. Milaeva // Herald of the Russian academy of sciences. - 2020. - Vol. 90, № 2. - P229-238
Кл.слова (ненормированные):
BETA-LACTAM ANTIBIOTICS -- BORON NEUTRON CAPTURE THERAPY -- FLUOROQUINOLONES -- HETEROCYCLES
Аннотация: A brief review of chemical elements, compounds from which find application in medicine, ranging from the commonly occurring organogenic elements (carbon, hydrogen, nitrogen, oxygen, sulfur, and phosphorus), composing the structure of proteins and nucleic acids of the cells of living organisms and determining the genetic transmission, to native rarely encountered organic fluorine compounds, synthetic derivatives of which have become firmly ingrained in the arsenal of modern pharmaceutical drugs, is given. Strong emphasis is put on metalloproteins, which play a significant role in the biochemistry of vitally essential processes, as well as metal compounds that are widely used in medicine. Of particular importance are the chemical elements and the isotopes, compounds of which are employed in nuclear medicine for diagnostics and treatment of a wide range of diseases, oncological and cardiovascular in particular.

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  пф - Читальный зал деловой и патентной информации

  рк - Фонд редкой книги

  ч/з - Главный читальный зал

  эр - Зал электронных ресурсов

  

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