H 65 Highly diastereoselective 1,3-dipolar cycloaddition of nonstabilized azomethine ylides to 3-nitro-2-trihalomethyl-2H-chromenes: synthesis of 1-benzopyrano[3,4-c]pyrrolidines [Electronic resource] / V. Yu. Korotaev, A. Yu. Barkov, V. S. Moshkin, E. G. Matochkina, M. I. Kodess, V. Ya. Sosnovskikh // Tetrahedron. - 2013. - Vol.69, №40. - P8602-8608. - Bibliogr. : p. 8608 (13 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): 3-NITRO-2H-CHROMENES -- NONSTABILIZED AZOMETHINE YLIDES -- 1,3-DIPOLAR CYCLOADDITION Аннотация: Reactions of 3-nitro-2-trifluoro(trichloro)methyl-2H-chromenes, including 2-unsubstituted derivatives, with N-alkyl-α-amino acids (sarcosine, proline) and paraformaldehyde proceed diastereoselectively to give 1-benzopyrano[3,4-c]pyrrolidines in good yields as a result of a 1,3-dipolar cycloaddition of the intermediate nonstabilized azomethine ylide at the Δ3-bond of the chromene system \\\\expert2\\NBO\\Tetrahedron\\2013, v. 69, p. 8602.pdf |
1,3-Dipolar cycloaddition of 3-alkylsulfanyl-2-arylazo-3-(tert-cycloalkylamino)acrylonitriles with N-methyl- and N-phenylmaleimides / N. P. Belskaia, S. G. Lesogorova, J. O. Subbotina, A. V. Koksharov, P. A. Slepukhin, W. Dehaen, V. A. Bakulev // Tetrahedron. - 2015. - Vol. 71. - С. 1438-1447 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): 1,3-DIPOLAR CYCLOADDITION -- 3-ALKYLSULFANYL -- N-PHENYLMALEIMIDES \\\\expert2\\NBO\\Tetrahedron\\2015, v. 71 , p. 1438.pdf |
Synthesis and antibacterial and antifungal activity of 3-(azol-1-yl)-6-r-1,2,4,5-tetrazines / R. I. Ishmetova, I. A. Belyaninova, A. V. Ignatenko [и др.] // Pharmaceutical chemistry journal. - 2020. - Vol. 53, № 10. - С. 899-904 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): 1,2,4,5-TETRAZINES -- 1,3-DIPOLAR CYCLOADDITION -- NUCLEOPHILIC SUBSTITUTION -- ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY Аннотация: Nucleophilic substitution and 1,3-dipolar cycloaddition reactions were used to synthesize 3,6-disubstituted derivatives of simm-tetrazine containing azolyl, aminoalkyl, and oxyalkyl fragments. The antibacterial activity of the resulting compounds was studied using the obligate pathogen Neisseria gonorrhoeae and opportunistic pathogenic microorganisms, while antifungal activity was assessed using anthropo- and zooanthropophilic dermatophytes. |