Н 52 Неожиданное превращение фторсодержащих CH-кислот при взаимодействии с хлоридом иода [] = Sudden conversion of fluorine-containing CH-acids during interaction with iodine chloride / В. Г. Пономарев, П. В. Подсевалов, Т. И. Назаренко, Л. Е. Деев, К. И. Пашкевич // Журнал органической химии. - 1990. - Т. 26, N 6. - С. 1365-1366 . - ISSN 0514-7492 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
S 98 Synthesis and antiviral activity of fluorinated 3-phenyl-1,2,4-benzotriazines [Electronic resource] / S. K. Kotovskaya, G. A. Zhumabaeva, N. M. Perova, Z. M. Baskakova, V. N. Charushin, O. N. Chupakhin, E. F. Belanov, N. I. Bormotov, S. M. Balakhnin, O. A. Serova // Pharmaceutical Chemistry Journal. - 2007. - Vol. 41, № 2. - P62-68. - Библиогр. : с. 68 (18 назв.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: New synthetic approaches to fluorinated 3-phenyl-1,2,4-benzotriazines for biological testing have been elaborated. 1-(3,4-Difluorophenyl)-3,5-diphenylformazan (IVa) was synthesized via dinitriding of 3,4-difluoroaniline, followed by azo-addition of the resulting azobenzenediazonium chloride with acetaldehyde phenylhydrazone. 6,7-Difluoro-3-phenyl-1,2,4-benzotriazine (Va) was obtained via intramolecular cyclization of formazan IVa in the presence of BF3/AcOH complex. Monofluoro-substituted 6-R-7-fluoro-3-phenyl-1,2,4-benzotriazine derivatives (Vb-Vq) were prepared by substituting fluorine atom with alkoxides in 3,4-difluoronitrobenzene. Conditions for nucleophilic substitution of the second fluorine atom in benzotriazines V have been established. Fluorinated 3-phenyl-1,2,4-benzotriazines have been tested for antiviral and cytotoxic activity on Vero cell cultures and proved to be active against severe diseases caused by smallpox and some other pathogenic viruses. ?? \\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2007, 41 (2), 62.pdf |
K 46 Kinetic resolution of 1-methyl- and 1-phenyl-3-amino-1,2-dicarba-closo-dodecaboranes via acylation with chiral acyl chlorides [Electronic resource] / G. L. Levit, V. P. Krasnov, A. M. Demin, M. I. Kodess, L. Sh. Sadretdinova, T. V. Matveeva, V. A. Ol'shevskaya, V. N. Kalinin, O. N. Chupakhin, V. N. Charushin // Mendeleev Communications. - 2004. - Vol. 14, № 6. - P293-295 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A study of the kinetic resolution of racemic 1-substituted 3-amino-1,2-dicarba-closo-dodecaboranes by chiral acyl chlorides has shown that N-tosyl-(S)-prolyl and N-phthaloyl-(S)-alaninyl chlorides are more efficient resolving agents than (S)-naproxen chloride. \\\\Expert2\\nbo\\Mendeleev Communications\\2004, v.14, p.293.pdf |
S 98 Synthesis, analgesic and antipyretic activity of 2-(antipyrin-4-yl)hydrazones of 1,2,3-triketones and their derivatives [Electronic resource] / E. V. Shchegol'kov, O. G. Khudina, L. V. Anikina, Ya. V. Burgart, V. I. Saloutin // Pharmaceutical Chemistry Journal. - 2006. - Vol. 40, № 7. - P373-376. - Библиогр. : с. 376 (10 назв.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: 1,2,3-Triketone 2-(antipyrin-4-yl)hydrazones were synthesized via the azo-coupling reactions of 1,3-diketones with 2-(antipyrin-4-yl)diazonium chloride. The fluoroalkyl-containing hetarylhydrazone enters into cyclocondensation with hydrazines at the 1,3-dicarbonyl fragment to yield 3-tetrafluoroethyl derivatives of pyrazole. It was found that 1,2,3-triketone 2-(antipyrin-4-yl)hydrazones and N-(2-hydroxyethyl)-substituted pyrazole exhibit analgesic activity comparable with that of their structural analog analgin (metamizole sodium), but do not possess antipyretic properties. In contrast, N-phenyl-substituted pyrazole did not exhibit analgesic properties but produced a certain antipyretic effect four hours after pyrogenic administration. Fluoroalkyl-containing compounds are less toxic substances than nonfluorinated 2-(antipyrin-4-yl)hydrazone and analgin. \\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2006, 40 (7), 373-376.pdf |
N 10 N-Phthaloyl-(S)-alanyl chloride as a chiral resolving agent for the kinetic resolution of heterocyclic amines [Text] / V. P. Krasnov, G. L. Levit, M. I. Kodess, V. N. Charushin, O. N. Chupakhin // Tetrahedron: Asymmetry . - 2004. - Vol. 15, № 5. - P859-862 : ил. - Библиогр.: с. 862 (7 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): HETEROCYCLIC AMINES -- CHLORIDE -- KINETIC RESOLUTION Аннотация: Acylation of heterocyclic amines with N-phthaloyl-(S)-alanyl chloride under kinetic resolution conditions resulted in the predominant formation of (S,S)-amides. The diastereoselectivity of resolution depended heavily on the structure of the resolved amine.???? \\\\Expert2\\nbo\\Tetrahedron Asymmetry\\2004, v.15, p.859.pdf |
A 10 A route to ethyl alfa-pentafluorobenzoyl-beta-oxobutanoate via its copper(II) chelate [Text] / Ya. V. Burgart, S. P. Kisil', V. I. Saloutin, O. N. Chupakhin // Mendeleev Communications. - 2001. - Vol. 11, № 2. - P76 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Ethyl 2-pentafluorobenzoyl-3-oxobutanoate has been prepared by the acylation of ethyl acetoacetate with pentafluorobenzoyl chloride via a copper(II) chelate |
E 54 Enantiomers of 3-amino-1-methyl-1,2-dicarba-closo-dodecaborane [Text] / V. P. Krasnov, G. L. Levit, V. N. Charushin, M. I. Kodess, V. N. Kalinin, O. N. Chupakhin // Tetrahedron: Asymmetry . - 2002. - Vol. 13, № 16. - P1833-1835. - Bibliogr. : p. 1835 (6 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The enantiomers of 3-amino-1-methyl-1,2-dicarba-closo-dodecaborane were prepared by means of resolution of the racemic mixture via acylation by (S)-naproxen chloride followed by separation and subsequent acid hydrolysis of each of the diastereoisomeric amides. Partial racemization of enantiomeric 3-aminocarboranes was observed during acid hydrolysis \\\\Expert2\\nbo\\Tetrahedron Asymmetry\\2002, v.13, p.1833.pdf |
K 46 Kinetic resolution of (±)-2-methyl-1,2,3,4-tetrahydroquinoline and (±)-2-methylindoline [Electronic resource] / V. P. Krasnov, G. L. Levit, I. N. Andreeva, A. N. Grishakov, V. N. Charushin, O. N. Chupakhin // Mendeleev Communications. - 2002. - Vol. 12, № 1. - P27-28 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The acylation of racemic 2-methyl-1,2,3,4-tetrahydroquinoline and 2-methylindoline by (S)-naproxen acyl chloride resulted in their kinetic resolution with the predominant formation of (S,S)-diastereoisomeric amides (de 78–76%), recrystallisation of which followed by acid hydrolysis gave individual (S)-isomers of heterocyclic amines???? \\\\expert2\\nbo\\Mendeleev Communications\\2002, v.12, N 1. p.27.pdf |
K 46 Kinetic resolution of (±)-2,3-dihydro-3-methyl-4H-1,4-benzoxazine in the reaction with (S)-naproxen chloride: A theoretical study [Electronic resource] / V. A. Potemkin, V. P. Krasnov, G. L. Levit, E. V. Bartashevich, I. N. Andreeva, M. B. Kuzminsky , N. A. Anikin, V. N. Charushin, O. N. Chupakhin // Mendeleev Communications. - 2004. - Vol. 14, № 2. - P69-70 : ил. - Библиогр.: с. 70 (14 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): KINETIC RESOLUTION -- CHLORIDE -- COMPUTATION METHODS Аннотация: The kinetic resolution of (±)-2,3-dihydro-3-methyl-4H-1,4- benzoxazine by the action of (S)-naproxen chloride was theoretically studied based on various computation methods. \\\\Expert2\\nbo\\Mendeleev Communications\\2004, v.14, p.69.pdf |
K 46 Kinetic resolution of (±)-2,3-dihydro-3-methyl-4H-1,4-benzoxazine, (±)-2-methyl-1,2,3,4-tetrahydroquinoline and (±)-2-methylindoline using N-tosyl-(S)-prolyl chloride [Text] / V. P. Krasnov, G. L. Levit, I. M. Bukrina, I. N. Andreeva, L. Sh. Sadretdinova, M. A. Koroleva, M. I. Kodess, V. N. Charushin, O. N. Chupakhin // Tetrahedron: Asymmetry . - 2003. - Vol. 14, № 14. - P1985-1988. - Bibliogr. : p. 1988 (6 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Acylation of racemic 2,3-dihydro-3-methyl-4H-1,4-benzoxazine, 2-methyl-1,2,3,4-tetrahydroquinoline and 2-methylindoline with N-tosyl-(S)-prolyl chloride resulted in their kinetic resolution with the predominant formation of (R,S)-diastereoisomeric amides, des being 80, 66 and 38%, respectively. Recrystallisation of the amides followed by acid hydrolysis gave individual (R)-enantiomers of heterocyclic amines \\\\Expert2\\nbo\\Tetrahedron Asymmetry\\2003, v.14, p.1985.pdf |
P 93 Prokhorov, A. M. CuCl2 induced reactions of 6-ethynyl- and 6-cyano-5-aryl-2,2-bipyridines with various N- and O-nucleophiles in comparison with the reactions of relative 1,2,4-triazines [Text] / A. M. Prokhorov, P. A. Slepukhin, D. N. Kozhevnikov // Journal of Organometallic Chemistry. - 2008. - Vol. 693, № 10. - P1886-1894 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Meanwhile 5-aryl-6-cyano-2,2-bipyridines are very stable towards various nucleophiles, addition copper(II) chloride to the reactional mixture facilitates nucleophilic addition to the cyano group dramatically. The cyanobipyridines react easily with water, methanol, ethanolamine in the presence of CuCl2 yielding well-crystallized complexes containing carboxylates, carboximidates or carboxamidines as ligands. 5-Cyano-1,2,4-triazines are more active in the reactions due to higher electron-withdrawing properties of this heterocycle. Due to the same reason acetylene moiety of 5-ethynyl-3-pyridyl-1,2,4-triazine adds water quite easily but in the presence of copper chloride as well \\\\Expert2\\nbo\\Journal of Organometallic Chemistry\\2008, v.693, p.1886.pdf |
M 57 Mercury sorption on a thiocarbamoyl derivative of chitosan [Text] / K. C. Gavilan, A. V. Pestov, H. M. Garcia, Yu. G. Yatluk, J. Roussy, E. Guibal // Journal of Hazardous Materials. - 2009. - Vol. 165, № 1-5. - P415-426 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The grafting of thiourea on chitosan backbone allows synthesizing a thiocarbamoyl derivative that was very efficient for mercury sorption in acidic solutions. Though the sorption capacity is not increased compared to raw chitosan in near neutral solutions, this modification allowed maintaining high sorption capacity (close to 2.3 mmol Hg g-1) at pH 2. Mercury sorption in acidic solutions is not affected by the presence of competitor metals (such as Zn(II), Pb(II), Cu(II), Cd(II), Ni(II)) or the presence of nitrate anions (even at concentration as high as 0.8 M)). The presence of chloride or sulfate anions (0.8 M) decreased Hg(II) sorption capacity to 1 mmol Hg g-1. Kinetics are controlled by a combination of pseudo second-order reaction rate and resistance to intraparticle diffusion. Mercury desorption reached about 75% using thiourea (in HCl solution) \\\\Expert2\\nbo\\Journal of Hazardous Materials\\2009, v.165.p.415.pdf |
U 62 Unusual transformation of a fluoroalkyl-containing beta-aminovinyl ketone [Electronic resource] / O. P. Krasnykh, N. S. Karpenko, V. I. Filyakova, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2004. - Vol. 53, № 6. - P1355-1356 : ил. - Библиогр.: с. 1356 (3 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): CHLORIDE -- KETONE DERIVATIVE -- CYCLIZATION -- FLUOROALKYL-CONTAINING BETA-AMINOVINYL KETONE \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2004, 53 (6), 1355.pdf |
K 81 Krasnykh, O. P. Synthesis of 5-alkyl-4-polyfluoroacylpyrrole-2,3(1H)-diones [Electronic resource] / O. P. Krasnykh, N. S. Karpenko, V. I. Filyakova // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2004. - Vol. 53, № 10. - P2340-2341 : ил. - Библиогр.: с. 2341 (9 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): FLUOROALKYL-CONTAINING BETA-AMINOVINYL KETONES -- OXALYL CHLORIDE -- PYRROLE-2,3(1h)-DIONES Аннотация: Diacylation of fluoroalkyl-containing beta-aminovinyl ketones with oxalyl chloride afforded 5-alkyl-4-polyfluoroacylpyrrole-2,3(1H)-diones. \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2004, 53 (10), 2340.pdf |
K 46 Kinetic resolution of Heterocyclic Amines using N-Tosyl-(S)-prolyl chloride [Text] : доклад, тезисы доклада / V. N. Charushin, V. P. Krasnov, G. L. Levit, I. N. Andreeva, I. M. Bukrina // XXth European Colloquium on Heterocyclic Chemistry, Stockholm,Sweden, 18-21 Aug. 2002 г. - Stockholm, 2002. - PA:7 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
S 98 Synthesis and structure of 4-hydroxy-4-fluoroalkyl-1,4-dihydroimidazo[5,1-c][1,2,4]triazines [Electronic resource] / E. V. Shchegol'kov, E. V. Sadchikova, Ya. V. Burgart, V. I. Saloutin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2009. - Vol. 45, № 4. - P572-580 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Azo coupling of fluorinated 1,3-diketones with 4-ethoxycarbonyl-1H-imidazole-5-diazonium chloride led to the formation of 4-hydroxy-4-polyfluoroalkyl-1,4-dihydroimidazo[5,1-c][1,2,4]triazines. According to the 1H and 19F NMR data, these compounds in solution give rise to ring-chain tautomerism via opening of the C4-N5 bond, which is especially characteristic of dihydroimidazotriazines with a polyfluoroalkyl substituent longer than trifluoromethyl group \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2009, 45 (4), 572.pdf |
S 98 Synthesis of ethyl 3-oxo-2-(3,4,5-trifluoro-2,6-dimethoxybenzoyl)butyrate [Electronic resource] / S. P. Kisil', M. I. Kodess, Ya. V. Burgart, V. I. Saloutin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2000. - Vol. 49, № 6. - P1090-1092 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Ethyl acetoacetate was acylated with 3,4,5-trifluoro-2,6-dimethoxybenzoyl chloride to give, for the first time, ethyl 3-oxo-2-(3,4,5-trifluoro-2,6-dimethoxybenzoyl)butyrate and its copper chelate. The title compound was used for the synthesis of 6,7,8-trifluoro-5-hydroxy-2-methylchromone, 1-(3,4,5-trifluoro-2,6-dimethoxyphenyl)butane-1,3-dione, and its copper chelate \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2000, 49 (6), 1090.pdf |
S 98 Synthesis of 4-acyl(alkoxycarbonyl)-5-fluoroalkyl-3,5-dihydroxyfuran-2(5H)-ones [Electronic resource] / M. V. Pryadeina, Ya. V. Burgart, K. I. Suslova, V. I. Saloutin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2002. - Vol. 51, № 9. - P1727-1730 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: 4-Acyl(alkoxycarbonyl)-5-fluoroalkyl-3,5-dihydroxyfuran-2(5H)-ones were obtained for the first time by the reactions of fluoroalkyl-containing 1,3-diketones and 3-oxo esters with oxalyl chloride \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2002, 51 (9), 1727.pdf |
A 37 Alkyl 3-fluoroalkyl-3-oxopropionates in reactions with azolyldiazonium salts [Electronic resource] / E. V. Shchegol'kov, E. V. Sadchikova, Ya. V. Burgart, V. I. Saloutin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2008. - Vol. 57, № 3. - P612-618 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Alkyl 3-fluoroalkyl-3-oxopropionates react with antipyrinyldiazonium chloride to form 2-antipyrinylhydrazono-3-fluoroalkyl-3-oxopropionates. The use in these reactions of hetaryldiazonium salts, containing NH group in the ? position, leads to alkyl 7-fluoroalkyl-7-hydroxy-4,7- dihydroazolo[5,1-c]triazine-6-carboxylates. 3-Amino-1H-1,2,4-triazole, 3-amino-4-ethoxycar- bonyl-1H-pyrazole, and 5-amino-4-ethoxycarbonyl-1H-imidazole were used as the heterocyclic component \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2008, 57 (3), 612.pdf |
B 43 Benzimidazo[l,2-a]pyrazolo[l,5-c]quinazoline: a novel heterocyclic system [Electronic resource] / G. N. Lipunova, G. A. Mokrushina, E. B. Granovskaya, O. M. Chasovskikh, V. N. Charushin // Mendeleev Communications. - 1996. - Vol. 6, № 1. - P15-17 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Heating of ethyl 3-[beta-(benzimidazol-2-yl)hydrazine]-2-(polyfluorobenzoyl)acrylates in acetonitrile with potassium fluoride or triethylbenzyl ammonium chloride leads to derivatives of novel heterocyclic systems of benzimidazo[l,2-a]pyrazolo- [1,5-c]quinazoline \\\\expert2\\nbo\\Mendeleev Communications\\1996, v.6, N 1. p.15.pdf |