R 32 Reduction of (2S,4S)-4-amino-5-oxoproline derivatives using borane complexes [Text] : доклад, тезисы доклада / A. Yu. Vigorov, I. A. Nizova, L. Sh. Sadretdinova, G. L. Levit, I. N. Ganebnuikh, M. A. Ezhikova, M. I. Kodess // Fifth International Conference on Organic Chemistry for young Scientists (InterYCOS-2009) "Universities Contribution in the Organic Chemistry Progress", devoted to the 175 th anniversary of D.I.Mendeleevs birthday and 80th anniversary of the Chemistry department of St. Petersburg State University foundation, Saint-Petersburg, 22-25 june 2009 : abstr. - СПб., 2009. - P39 (1-07). - Bibliogr. : p. 40 (7 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ |
N 52 New insights in to the treatment of myocardial infarction / P. Sarapultsev, O. N. Chupakhin, A. Sarapultsev, M. Rantsev, S. Medvedeva, I. Danilova // International journal of experimental pathology. - 2012. - Vol. 93, № 1. - С. 18-23. - Bibliogr. : p. 23 (18 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): INFLAMMATION -- L-17 COMPOUND -- MYOCARDIAL INFARCTION Аннотация: This study investigated the effects of the L-17 compound of the group of substituted 5R1, 6H2-1,3,4-thiadiazine-2-amines on the inflammatory cellular infiltration and myocardial remodelling which occurs after acute myocardial infarction (MI) in rats. The study is based upon recent clinical and experimental work which demonstrated the role of local and systemic inflammatory reactions in postinfarction remodelling. Acute MI in rats was induced by left coronary artery coagulation. Animals were sacrificed on day one, five and seven after MI induction. The myocardiumal samples were taken from all parts of the heart and examined by histology. This included areas of infarction, infraction and areas that were peri-infarctiom and left ventricular areas distant from the damaged tissues. Serum activity of creatine phosphokinase (CPK), aspartate aminotransferase (AST), isoenzymes 1 and 2 and lactate dehydrogenase (LDH1-2) were investigated on the same three days, before and in the process of MI development was investigated (at days 1, 5 and 7). The L-17 compound to not only decreased the area of initial infarction but also changed the pattern of inflammatory reaction in the affected myocardium fundamentally. Laboratory studies of effects of L-17 compound on the development and course of experimental MI showed that administration decreased blood AST and CPK levels significantly and provided useful the data about the correlation between the activity of these enzymes and the dimensions of the significantly necrotic area. In this model of experimental MI the use of the L-17 compound induced led to the replacement of the exudative destructive inflammation that is seen under standard conditions with a more cellular productive pattern of inflammation, with associated reduction in initial necrosis area and the, decrease in myocardial ischaemia and reperfusion injury may account for the accelerated repair process |
I-60 Influence of a biologically active compound from substituted thiadiazines on transaminase activity in myocardial homogenate in experimental myocardial infarction [Electronic resource] / O. N. Chupakhin, A. Sarapultsev, M. Chereshneva, I. Gette, L. P. Sidorova, I. Danilova, P. Sarapultsev // International Journal of Pharmacy and Pharmaceutical Sciences. - 2015. - Vol. 7, № 6. - С. 147-151. - Bibliogr. : p. 151 (21 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ENZYMES -- MYOCARDIAL INFARCTION -- L-17 COMPOUND Аннотация: Objective: Earlier works have reported on the effectiveness of the compounds of the group of substituted 5R1, 6R2, 3,4-thiadiasine-2-amines for treating experimental myocardial infarction, conditioned by the immune-modifying action of the compound. The purpose of this study was to evaluate the action of the L17 compound of the group of substituted 5R1, 6R2, 3,4-thiadiasine-2-amines on the extent of injury and the possible recurrence of experimental myocardial infarction by the dynamic assessment of transaminase activity in blood and myocardial homogenate (tissue). Methods: Modelling of myocardial infarction in rats was performed in accordance with the author’s modification of the standard ligation model. Tissue enzyme activity of LDH and CK-MB was evaluated at days 1, 7, and 14. Results: According to the results, the decrease in LDH 1-2 activity in tissue (after experimental myocardial infarction) corresponded to the increase in enzyme activity in blood on the first day of the experiment. However, on the seventh day of the experiment, the decrease of LDH 1-2 activities in the tissue of animals treated with L17 compound corresponded with the decrease of LDH activity in blood, while in non-treated animals the relation between the enzyme levels in blood and tissue was typical for the onset of MI. Conclusions: The evaluation of enzyme levels in myocardial tissue confirms previouslyreported data that the administration of a thiadiazine compounds prevents the recurrence and decreases the size of experimental myocardial infarction. \\\\expert2\\nbo\\International Journal of Pharmacy and Pharmaceutical Sciences\\52015. V. 7, N 6. P. 147-151.pdf |