T 44 The elaboration of New Elementorganic Hydrogels for Pharmaceutical Compositions of Local and External Application: the 3rd China-Russia international symposium on pharmacology [Text] : доклад, тезисы доклада / L. P. Larionov, T. G. Khonina, P. V. Sorokin, E. V. Shadrina, A. A. Boyko, N. A. Zabokritskii, G. B. Philippova, O. N. Chupakhin // Pharmacology. - Harbin : Harbin medical university, 2008. - P4-5 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): HYDROGELS -- GLYCEROLATES |
С 38 Синтез, токсичность и трансдермальная проницаемость глицератов кремния и гидрогелей на их основе [] = Synthesis, toxicity, and percutaneous activity of silicon glycerolates and related hydrogels / Т. Г. Хонина, О. Н. Чупахин, Л. П. Ларионов, Т. Г. Бояковская, А. Л. Суворов, Е. В. Шадрина // Химико-фармацевтический журнал. - 2008. - № 11. - С. 5-9 : рис., табл., граф. - Библиогр.: с. 9 (12 назв.) . - ISSN 0023-1134 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): КРЕМНИЙ -- ГЛИЦЕРАТЫ КРЕМНИЯ -- ГИДРОГЕЛИ -- ГЕЛЕОБРАЗОВАНИЕ -- ПРОВОДНИКИ ТРАНСКУТАННЫЕ -- СИНТЕЗ -- ТОКСИЧНОСТЬ -- ПРОНИЦАЕМОСТЬ ТРАНСДЕРМАЛЬНАЯ |
S 85 Stnthesis, toxicity, and percutaneous activity of silicon glycerolates and related hydrogels [Electronic resource] / T. G. Khonina, O. N. Chupakhin, L. P. Larionov, T. G. Boyakovskaya, A. L. Suvorov, E. V. Shadrina // Pharmaceutical Chemistry Journal. - 2008. - Vol. 42, № 11. - P609-613 : il. - Bibliogr. : p. 612 (12 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): SILICON -- SILICON GLYCEROLATES -- HYDROGELS -- SYNTHESIS -- TOXICITY -- PERCUTANEOUS ACTIVITY \\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2008, 42 (11), 609.pdf |
B 83 Boyakovskaya, T. G. Siliconorganic glicerohydrogels as a new base for creation of medical and curative-cosmetic oinments [Text] / T. G. Boyakovskaya, L. P. Larionov, T. G. Khonina // China-Russia. International Confernce on Pharmacology, Harbin, July 1-4 2005. - Harbin, China, 2005. - P50-51 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ |
M 45 Mechanism of structural networking in hydrogels based on silicon and titanium glycerolates / T. G. Khonina, A. P. Safronov, E. V. Shadrina, M. V. Ivanenko, A. I. Suvorova, O. N. Chupakhin // Journal of Colloid and Intrface Science. - 2012. - Vol. 365, № 1. - С. 81-89 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): HOFMEISTER SERIES -- TITANIUM–GLYCEROL HYDROGELS -- SCHULTZE–HARDY RULE Аннотация: Formation of organic/inorganic hydrogels based on silicon– and titanium–glycerol precursors synthesized by transesterification of alkoxy derivatives in excess of glycerol was investigated. The precursors in excess of glycerol and obtained gels were studied by chemical and physical methods including gelation kinetics, IR spectroscopy, XRD, dynamic and electrophoretic light scattering, mechanical deformation, which disclosed the basic difference in the gelation mechanism and structure of network in the hydrogels. Due to this difference, the gelation time of silicon– and titanium–glycerol precursors depended on pH or electrolyte addition in an opposite way. In the wide pH range, silicon–glycerol hydrogel was a polymeric single-phase system formed by the polymeric network homogeneously swollen in liquid water/glycerol medium. Flory–Rehner theory applied to the elastic modulus of these gels gave 40–180 monomer base units in the subchains of the network depending on water content in the gel. The mechanism of networking was three-dimensional polycondensation promoted by the electrically charged functional groups attached to the flexible polymeric chains. Electrolyte solutions provided the gelation according to Hofmeister series. Titanium–glycerol hydrogels were heterogeneous colloid systems at pH > 1.5 and single-phase polymeric gels at lower pH. Electrolyte solutions provided the gelation according to Schultze–Hardy rule \\\\Expert2\\nbo\\Journal of Colloid and Interface Science\\2012, v.365, p.81.pdf |
S 98 Synthesis of pharmacologically active hydrogels [Electronic resource] / M. V. Ivanenko, T. G. Khonina, O. N. Chupakhin, L. P. Larionov // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2012. - Vol.61, №11. - С. 2163-2171. - Bibliogr. : p. 2171 (30 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): SILICON POLYOLATES -- TITANIUM POLYOLATES -- WOUND-HEALING Аннотация: The target synthesis of new biologically active hydrogels based on combined silicon and titanium polyolates was carried out. The optimum conditions for hydrogel formation and their composition were determined. The type of hydrogels and mechanisms of gelation depend on the nature of polyols: gels based on combined silicon and titanium polyethylene glycolates are polymeric and formed via the polycondensation mechanism, whereas gels based on combined silicon and titanium glycerolates are colloidal and formed via the coagulation—condensation mechanism. The combined hydrogels based on silicon dimethyl glycerolates and titanium tetraglycerolate exhibit enhanced transcutaneous, wound healing, and regenerating activity \\\\expert2\\NBO\\Russian Chemical Bulletin\\2012, 61 (11), 2163-2171.pdf |
S 70 Sol-gel synthesis of titanum dioxide by hydrolysis of titanium glycerolates and peroxides [Electronic resource] / V. A. Osipova, G. S. Zakharova, E. Andreikov, Yu. G. Yatluk, I. Puzyrev // Glass Physics and Chemistry. - 2013. - Vol.39, №4. - С. 398-402. - Bibliogr. : p. 402 (11 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): PHOTOCATALYSIS -- SOL-GEL -- TITANIUM DIOXIDE Аннотация: The sol-gel synthesis of titanium dioxide from titanium glycerolate (TG) and titanyl sulfate was studied. The effect of hydrothermal treatment in an autoclave at 130 C and refluxing TG with the peroxo titanium acid gel on the product properties, i.e.; morphology of the nanoparticles and their aggregates, as well as their ability to adsorption and photocatalytic degradation of methylene blue in aqueous solutions was discussed |
N 52 New hybrid chitosan-silicone-containing glycerohydrogels [Electronic resource] / E. Yu. Larchenko, E. V. Shadrina, T. G. Khonina, O. N. Chupakhin // Mendeleev Communications. - 2014. - Vol.24, №4. - С. 201-202. - Bibliogr. : p. 202 (20 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): CHITOSAN -- GLYCEROHYDROGELS -- SOL-GEL METHOD Аннотация: New biologically active hybrid chitosan-silicone-containing glycerohydrogels based on chitosan and silicon glycerolates were synthesized by a sol-gel method; the effect of silicon glycerolates and chitosan concentrations on the process of gel formation was evaluated. |
N 52 New hybrid chitosan–silicone-containing glycerohydrogels [Electronic resource] / E. Yu. Larchenko, E. V. Shadrina, T. G. Khonina, O. N. Chupakhin // Mendeleev Communications. - 2014. - Vol.24. - С. 201-202 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): CHITOSAN -- GLYCEROHYDROGELS -- SILICON GLYCEROLATES Аннотация: New biologically active hybrid chitosan–silicone-containing glycerohydrogels based on chitosan and silicon glycerolates were synthesized by a sol–gel method; the effect of silicon glycerolates and chitosan concentrations on the process of gel formation was evaluated. \\\\expert2\\nbo\\Mendeleev Communications\\2014, v.24, p. 201-202.pdf |
S 98 Synthesis and antimicrobial activity of silicon-titanium-zinc- and silicon-titanium-boron-containing glycerohydrogels / T. G. Khonina, E. Yu. Nikitina, E. V. Shadrina [et al.] // Russian chemical bulletin. - 2021. - Vol. 70, № 5. - P967-974 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Novel pharmacologically active silicon—titanium—zinc- and silicon—titanium—boron-containing glycerohydrogels were synthesized by the sol—gel method using silicon, titanium, zinc, and boron glycerolates as biocompatible precursors. The compositions and structural features of the hydrogels were studied by transmission electron microscopy, scanning electron microscopy, IR spectroscopy, atomic emission spectrometry, and elemental analysis methods. The disperse phase and liquid water—glycerol medium of the hydrogels were isolated by cold exhaustive extraction with ethanol and characterized. The 3D polymeric network of the gels is formed by the products of hydrolysis and subsequent (co)condensation of silicon-/silicon—boron-containing precursors. Titanium and zinc glycerolates undergo no hydrolytic transformations under gelation conditions and exist in the cells of the 3D polymeric network in the form of amorphous nanoparticles that are not linked to the network by covalent bonds. Models of the structures were proposed. The gels are characterized by antimicrobial activity, which is more pronounced for the silicon—titanium—boron-containing gel, and they can be considered as promising drugs for topical treatment prepared by the simple, environmentally friendly, and cost-effective method. |
Bioactive silicon-iron-containing glycerohydrogel synthesized by the sol-gel method in the presence of chitosan / T. G. Khonina, D. S. Tishin, L. P. Larionov [et al.] // Russian chemical bulletin. - 2022. - Vol. 71, № 11. - P2342-2351 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A novel biologically active nanocomposite glycerohydrogel based on two biocompatible precursors, silicon and iron glycerolates, was synthesized by the sol—gel method in the presence of chitosan (Ch). The composition and structural features of the gel were characterized by advanced analytical methods including transmission electron microscopy, X-ray diffraction, and atomic emission spectroscopy. It was shown that iron(iii) monoglycerolate undergoes partial hydrolysis under the gelation conditions and exists as a separate nanoscale phase along with the hydrolysis products in cells of the 3D Si-containing polymeric gel network. This network is formed as a result of incomplete hydrolysis of silicon glycerolates in excess glycerol followed by homo- and heterofunctional condensation of silanol groups with the formation of Si-O-Si units containing residual glyceroxy groups at the silicon atom. Chitosan forms numerous intermolecular bonds with the 3D gel network, accelerates the process of gelation, makes the gel morphostructure more ordered, and increases the stability of the gel. The Si-Fe-Ch-containing glycerohydrogel is nontoxic and possesses hemostatic and wound-healing activity, being a promising topical medication for medical and veterinary practice. |
Individual iron(III) glycerolate: synthesis and characterisation / T. G. Khonina, E. Y. Nikitina, D. S. Tishin [et al.] // RSC Advances. - 2022. - Vol. 12, № 7. - P4042-4046 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Iron(II) and iron(III) salts of strong acids form iron glycerolates on heating at 180 °C with glycerol in the presence of an equivalent amount of alkali. Individual iron(III) glycerolate was obtained for the first time. When Fe3O4 magnetic nanoparticles were heated with glycerol, an iron(III) glycerolate shell was formed on their surface. |