S 70 Solvent-free synthesis of pillar[6]arenes [Electronic resource] / S. Santra, D. S. Kopchuk, I. S. Kovalev, G. V. Zyryanov, A. Majee, V. N. Charushin, O. N. Chupakhin // Green Chemistry. - 2016. - Vol. 18. - С. 423-426. - Bibliogr. : p. 5 (16 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): PILLAR[6]ARENES -- SOLVENT-FREE PROCEDURE Аннотация: An efficient solvent-free procedure for the synthesis of pillar[6]arenes has been developed. The procedure involves the solid-state condensation of finely milled 1,4-dialkoxybenzene and paraformaldehyde by grinding in the presence of a catalytic amt. of H2SO4. The use of org. solvents for the extn. of products has also been avoided. Operational simplicity, compatibility with various 1,4-dialkoxybenzenes, non-chromatog. purifn. technique, high yields and mild reaction conditions are the notable advantages of this procedure. A large scale reaction demonstrated the practical applicability of this methodol. \\\\expert2\\nbo\\Green Chemistry\\2015. Accepted Manuscript. P. 1-5. pdf.pdf |
Synthesis of 2-imidazolines by co-grinding of n-tosylaziridines and nitriles / A. De, A. Majee, S. Santra [et al.] // Mendeleev Communications. - 2020. - Vol. 30, № 2. - P188-189 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): 2-IMIDAZOLINES -- AZIRIDINES -- GRINDING -- HETEROCYCLIZATION -- NITRILES -- SOLVENT-FREE REACTIONS Аннотация: Solvent-free solid-state co-grinding of N-tosylaziridines and nitriles in the presence of perchloric acid as the catalyst affords 2-imidazolines in good yields. |
Iron(III)-catalyzed multicomponent synthesis of highly substituted pyrroles under ball-milling conditions / A. Mukherjee, S. Al-Ghezi Basim, G. V. Zyryanov, O. N. Chupakhin // Современные синтетические методологии для создания лекарственных препаратов и функциональных материалов" (MOSM 2021): V международная конференция: сборник тезисов. - Екатеринбург, 2021. - C. PR-186 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Nowadays, green chemistry plays an important role for environment. In this context, development of solvent-free ball milling or a grinding approach has attracted considerable interest in organic synthesis.1 Hence, carrying out a reaction under solvent-free conditions and at room temperature is an effective approach to eliminate the use of volatile organic compounds and to obtain the greenness in the process. On the other hands, pyrroles are the small aromatic, nitrogen-containing heterocyclic compounds present in many natural products.2 Pyrrole molecules show important biological relevance such as porphyrins, bile pigments, and coenzymes and are known to exhibit various applications as organic materials.3 In this work, we have presented a highly robust one-pot, four-component cascade cyclization reaction of α-keto aldehydes, anilines, activated alkynes, and aromatic nucleophiles to synthesize a diverse range of pharmaceutically important penta-substituted pyrroles. The reaction proceeded smoothly under ball-milling conditions in presence of iron catalyst. |