А 61 Амбидентные свойства 4-замещенных тиосемикарбазидов в конденсациях с фторуксусными кислотами [] = Ambident properties of 4-substituted thiosemicarbazides in condensations with fluoroacetic acids / Е. Б. Васильева, В. И. Филякова, В. Н. Чарушин, Л. П. Сидорова, И. Е. Филатов // Журнал органической химии. - 2005. - Т. 41, N 10. - 1553-1556: рис. - Библиогр. : с. 1556 (14 назв.) . - ISSN 0514-7492 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Взаимодействие 4-замещенных тиосемикарбазидов с ди- и трифторуксусными кислотами ведет к образованию 4,5-дигидро-3-фторалкил-4-арил(гетерил)-1,2,4-триазол-5(1H)-тионов,в то время как в результате конденсации 4,4-дизамещенных тиосемикарбазидов с трифторуксусной кислотой образуются 5-фторалкил-2-гетерил-1,3,4-тиадиазолы |
S 98 Synthesis of trifluoroalkyl- and fluoroaryl-substituted 4,5-dihydro-1H-1,2,4-triazole-5-thiones [Electronic resource] / E. B. Vasil'eva, D. V. Sevenard, O. G. Khomutov, O. A. Kuznetsova, N. S. Karpenko, V. I. Filyakova // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2004. - Vol. 40, № 6. - P874-878. - Библиогр. : с. 878 (8 назв.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Reactions of 4-(4-fluorophenyl)-, 4-(4-trifluoromethoxyphenyl)-, 4-(3,4-difluorophenyl)-, 4-(4-trifluoromethylphenyl)-, 4-piperidino-, and 4-(3-pyridyl)thiosemicarbazides with esters gave the corresponding 3,4-disubstituted 4,5-dihydro-1H-1,2,4-triazole-5-thiones and their S-alkyl derivatives. Analogous reactions with methyl 2,2,3,3,4,4,5,5-octafluoropentanoate and 2,2,3,3,4,4,5,5-octafluoropentanenitrile afforded, respectively, the acylation and addition products. \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2004, 40 (6), 874.pdf |
F 70 Fluorine-containing heterocycles. XVI. Reactions of tetrafluorobenzoyl isothiocyanate with hydrazines and their derivatives [Electronic resource] / E. V. Nosova, G. N. Lipunova, A. A. Laeva, L. P. Sidorova, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2007. - Vol. 43, № 1. - P68-76 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Fluorinated derivatives of 4H-1,3-benzothiazin-4-one, [1,2,4]triazolo[4,3-a]pyrimidine, [1,2,4]triazolo[3,4-b][1,3]benzazoles, and 1,5-dihydro-1,2,4-triazole-5-thione were synthesized by addition of hydrazines and their derivatives to tetrafluorobenzoyl isothiocyanate, followed by cyclization of intermediate thiosemicarbazides \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2007, 43 (1), 68.pdf |
A 46 Ambident Properties of 4-Substituted Thiosemicarbazides in Condensations with Fluoroacetic Acids [Electronic resource] / E. B. Vasil'eva, V. I. Filyakova, L. P. Sidorova, I. E. Filatov, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2005. - Vol. 41, № 10. - P1522-1525 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: 4-Substituted thiosemicarbazides react with di- and trifluoroacetic acids to give the corresponding 3-fluoroalkyl-4,5-dihydro-1,2,4-triazole-5(1H)-thiones. Condensation of 4,4-disubstituted thiosemicarbazides with trifluoroacetic acid leads to formation of 2-amino-5-trifluoromethyl-1,3,4-thiadiazoles \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2005, 41 (10), 1522.pdf |
S 98 Synthesis of New 1,3,4-Thiadiazines Capable of Inhibiting Nonenzymatic Glycosylation of Proteins [Electronic resource] / L. P. Sidorova, T. A. Tseitler, N. M. Perova, V. V. Emel’yanov, E. A. Savateeva, N. E. Maksimova, N. N. Mochul’skaya, V. A. Chereshnev, O. N. Chupakhin // Pharmaceutical Chemistry Journal. - 2015. - Vol. 49, № 8. - С. 501-505. - Bibliogr. : p. 505 (12 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): 1,3,4-THIADIAZINE -- CYCLOCONDENSATION -- NONENZYMATIC GLYCOSYLATION OF PROTEINS -- THIOSEMICARBAZIDES Аннотация: A series of new 1,3,4-thiadiazines with cycloalkylamino (cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino) groups were synthesized via cyclocondensation of α-haloacetophenones with thiosemicarbazides containing 4-cycloalkyl groups. Five of the synthesized compounds showed the capability to inhibit nonenzymatic glycosylation of proteins in vitro in a model system. The obtained test results allowed compounds containing cyclopropylamino residues (LT-1a and LT-1d) to be recommended for further in vivo testing \\\\expert2\\nbo\\Pharmaceutical Chemistry Journal\\2015, 49 (8), 501-505.pdf |