H 86 Hristov, P. K. Lipid peroxidation induced by ultrasonication in Ehrlich ascitic tumor cells [] / P. K. Hristov, L. A. Petrov, E. M. Russanov // Cancer Letters. - 1997. - Vol.121, N1. - С. 7-10 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The mechanism of sonodynamic action in tumor cells is poorly investigated. It is known that ultrasound generates free radicals in phosphatidylcholine liposomes used as a membrane model. The participation of lipid peroxidation products in the mechanisms of physiological suppression of cell multiplication has been investigated for some tumor cells |
R 95 Rusinov, G. L. A convenient sonochemical synthesis of vicinally substituted 3-hydroxylaminopyridines [Electronic resource] / G. L. Rusinov, I. E. Filatov, K. I. Pashkevich // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 1993. - Vol. 42, № 2. - P325-327 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A method of synthesis of vicinally substituted N-(3-pyridyl)hydroxylamines by reducing the corresponding nitropyridines with Zn/NH4Cl/EtOH under ultrasonication is proposed. Ultrasound irradiation increases the yields of these hydroxylamines and facilitates their isolation. \\\\Expert2\\nbo\\Russian Chemical Bulletin\\1993, 42 (2), 325.pdf |
Design, synthesis, biological evaluation and molecular docking studies of 1,4-disubstituted 1,2,3-triazoles: peg-400:h2o mediated click reaction of fluorescent organic probes under ultrasonic irradiation / C. K. R. Reddivari, S. R. Devineni, R. R. Yellalavenkata [et al.] // Polycyclic aromatic compounds. - 2021. - Vol. 42, № 7. - P3953-3974 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ULTRASONICATION -- 123-TRIAZOLE -- ANTIOXIDANT ACTIVITY Аннотация: The perpetual demand of medicinally significant scaffolds has prompted the synthetic chemists to identify simple and efficient routes for flawless synthesis. A PEG-400:H2O mediated highly versatile, efficacious and selective “Click reaction” of fluorescent organic Probes under ultrasonic irradiation is reported. 1,2,3-Triazole ring has also been revealed to play a crucial role in bioorthogonal methodologies, fragment-based drug design, and biomolecular mimetics. This methodology provides a rapid and efficient approach for the synthesis of 1,4-Disubstituted 1,2,3-triazoles under Copper (I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition (CuAAC) conditions in good to excellent yields in less time. This synthetic protocol has been proven to endorse easy work-up under benign reaction conditions. The green solvent system employed has been efficaciously reused several times without any loss of its activity in an aqueous medium. All the title compounds were characterized by using elemental analysis, 1HNMR, 13CNMR, FTIR, and mass spectral data. The newly synthesized compounds were biologically evaluated for their antioxidant activity. The antioxidant activity results demonstrate that all compounds showed good to excellent antioxidant activity, particularly the compounds 5d, 8 b, 8c and 8d exhibited promising radical scavenging activity. Further, photophysical properties of the compounds were accomplished using spectrofluorimeter. By this method, compounds 5c, 5e, 5f, 8a, 8 b, 8c and 8d exhibited fluorescence in the visible region. Molecular docking studies suggested the antioxidant activity of synthesized compounds due to the inhibition of neuronal nitric oxide synthase (HnNOS). https://doi.org/10.1080/10406638.2021.1878246 |
Azolyl pyrimidines-synthesis and antimicrobial activity / N. H. Basha, T. Rekha, V. Padmavathi [et al.] // AIP conference proceedings. - 2022. - Vol. 2390. - Ст. 020006 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): CHEMICAL COMPOUNDS -- PHARMACEUTICALS -- ANTIMICROBIALS Аннотация: Amide unit is a privileged structural motif and is a constituent of proteins, natural products and pharmaceuticals. Amongst different heterocyclic scaffolds, azoles and pyrimidines are the prominent entities in pharmaceutical arena. The biopotency of these heterocycles have triggered to synthesize a variety of heteroaromatics – azoles linked with pyridines by amino acetamide group. The target molecules-azolylaminoacetamidopyrimidines were prepared by the reaction of methyl azolylglycinate with pyrimidinyl-2-amine in the presence of DMAP and triethylamine in dichloromethane under ultrasonication. The lead molecules were evaluated for antimicrobial activity. Nitro substituted 2-((4-(4-chlorofuran-2-yl)thiazole-2-yl)amino)-N-(4,6-diphenylpyrimidin-2-yl)acetamide (9c) displayed excellent antibacterial activity against B. subtilis greater than the standard drug Chloramphenicol. However, 9c and nitro substituted 2-((4-(4-chlorofuran-2-yl)-1H-imidazol-2-yl)amino)-N-(4,6-diphenylpyrimidin-2-yl)acetamide (10c) showed antifungal activity on A. niger greater than the standard drug Ketoconazole. |
Bis(azolyl)sulfonamidoacetamides: Synthesis and bioassay / P. S. Sankar, K. N. Babu, V. N. Padmavathi [et al.] // AIP conference proceedings. - 2022. - Vol. 2390. - Ст. 020021 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ANTIMICROBIALS -- BIOASSAYS -- ANTIFUNGAL Аннотация: Azole derivatives are valuable precursors in pharmacological arena. In fact, oxazole, thiazole and imidazole containing scaffolds display a variety of biological activities such as antitumor,1 antibacterial,2 antiviral,3 antioxidant,4,5 anti-inflammatory6 and antifungal7 activities. Azoles are also prominant molecules in various biochemical and synthetic transformations. Based on the importance of these heteroaromatics and also our interest to link the heterocycle molecules with a variety of functional groups we have synthesized a new class of bis(azolyl)sulfonamide acetamides from azolylsulfonylamines and azolylchloroacetamides in the presence of DMAP under ultrasonication and studied their antimicrobial activity. The compounds chloro substituted bis(thiazoles) (6c) and chloro substituted imidazolyl thiazoles (7c) displayed excellent antibacterial activity against B. subtilis greater than the standard drug, Chloramphenicol. Whereas 7c also showed excellent antifungal activity on A. niger higher than the standard drug, Ketoconazole. |