Z 99 [4+2]Cycloadition reactions of substituted 1,2,4,5-tetrazines with alkenes [Text] : доклад, тезисы доклада / R. I. Ishmetova, G. L. Rusinov, N. I. Latosh, N. K. Ignatenko> // International Memorial I.Postovsky Conference on Organic Chemisty, Ekaterinburg, March 17-20, 1998 : program and abstracts. - Ekaterinburg, 1998. - P69 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
L 36 Latosh, N. I. Nucleophilic Substitution Reactions in the Series of (3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazines [Text] : доклад, тезисы доклада / N. I. Latosh, G. L. Rusinov, E. G. Polovinko> // International Memorial I.Postovsky Conference on Organic Chemisty, Ekaterinburg, March 17-20, 1998 : program and abstracts. - Ekaterinburg, 1998. - P90 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
M 78 Modeling of 1,2,4,5-tetrazine complexes with organic amines [Electronic resource] / M. A. Grishina, V. A. Potemkin, E. V. Bartashevich, A. N. Sinyaev, G. L. Rusinov, N. I. Latosh, I. N. Ganebnuikh, O. V. Koryakova, R. I. Ishmetova> // Journal of Structural Chemistry. - 2006. - Vol. 47, № 6. - P1155-1160 Рубрики: ХИМИЧЕСКИЕ НАУКИ \\\\Expert2\\nbo\\Journal of Structural Chemistry\\2006, V. 47, N 6, p.1155.pdf |
S 98 Synthesis and tuberculostatic activity of some substituted amino acid methyl esters with sym-tetrazine moieties [Electronic resource] / G. L. Rusinov, N. I. Latosh, R. I. Ishmetova, M. A. Kravchenko, I. N. Ganebnuikh, V. A. Sokolov, O. N. Chupakhin> // Pharmaceutical Chemistry Journal. - 2005. - Vol. 39, № 1. - P8-10 Рубрики: ХИМИЧЕСКИЕ НАУКИ \\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2005, 39 (1), 8.pdf |
Z 99 [4+2]-Cycloaddition of 3,6-bis(3,5-dimethyl-4-R-pyrazol-1-yl)-1,2,4,5-tetrazines with alkenes [Electronic resource] / G. L. Rusinov, R. I. Ishmetova, N. I. Latosh, I. N. Ganebnuikh, O. N. Chupakhin, V. A. Potemkin> // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2000. - Vol. 49, № 2. - P355-362 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A number of 1,4-dihydropyridazines and pyridazines were prepared by the Diels-Alder reaction with an inverse electron demand from cyclic heterodiene systems, 3,6-bis(3,5-dimethyl-4-R-pyrazol-1-yl)-1,2,4,5-tetrazines, and some enamines as well as from 4-vinylpyridine, butyl vinyl ether, phenylacetylene, and acrylamide. The reaction of 3,6-bis(3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazine with styrene afforded 4,5-dihydropyridazine, which was readily oxidized by atmospheric oxygen to form the corresponding pyridazine. Electron-withdrawing substituents (Br or Cl) in the pyrazole rings accelerate [4+2]-cycloaddition. When heated, 1,4-dihydropyridazines, which were synthesized from tetrazines and enamines, eliminated amine to give pyridazines. The reactivities of tetrazines were evaluated by quantum-chemical methods. \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2000, 49 (2), 355.pdf |
S 98 Synthesis of 1,2,4,5-tetrazines, symmetrically and unsymmetrically 3,6-disubstituted by N-nucleophiles [Electronic resource] / G. L. Rusinov, N. I. Latosh, I. N. Ganebnuikh, R. I. Ishmetova, N. K. Ignatenko, O. N. Chupakhin> // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2006. - Vol. 42, № 5. - P757-765 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: 6-R-3-(3,5-Dimethylpyrazol-1-yl)-1,2,4,5-tetrazines with aliphatic, cycloaliphatic, and aromatic amines, and also with NH-heterocycles undergo a nucleophilic substitution of the dimethylpyrazole moiety yielding symmetrically and unsymmetrically substituted 1,2,4,5-tetrazines. In the 3,6-diimidazolyl-and 3,6-dibenzotriazolyl derivatives reactions of nucleophilic substitution of the heterocyclic moiety also occur. In some cases an ipsosubstitution of amino, hydrazino, and azido groups is observed. \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2006, 42 (5), 757.pdf |
R 44 Replacement of dimethylpyrazolyl group in 1,2,4,5-tetrazines by aliphatic alcohols and water [Electronic resource] / R. I. Ishmetova, N. I. Latosh, I. N. Ganebnuikh, N. K. Ignatenko, S. G. Tolshchina, G. L. Rusinov> // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2009. - Vol. 45, № 7. - P1102-1107 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Reactions of 3,6-bis(4-R-3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazines and 3-amino-6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazines with aliphatic alcohols and water in the presence of a base involved replacement of the dimethylpyrazolyl group and resulted in the formation of mono- and dialkoxy-1,2,4,5-tetrazines and 6-substituted 3-hydroxy-1,2,4,5-tetrazines. Dissociation constants of the latter were determined by potentiometric titration. \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2009, 45 (7), 1102.pdf |
C 45 Changes in the vibrational characteristics of substituted 1,2,4,5-tetrazines after complexation with 1,2,3-benzotriazole: A theoretical study [Electronic resource] / N. N. Ivshina, E. V. Bartashevich, V. A. Potemkin, M. A. Grishina, R. I. Ishmetova, G. L. Rusinov, N. I. Latosh, P. A. Slepukhin, V. N. Charushin> // Journal of Structural Chemistry. - 2009. - Vol. 50, № 6. - P1053-1058 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The complexation of 3,6-substituted 1,2,4,5-tetrazines with benzotriazole was studied theoretically based on the vibrational spectra. For model complexes, the energy was minimized by the geometrical parameters, and the spectral characteristics were calculated by the PM3 method. The shift of the bond vibration frequencies of the atoms involved in complexation after the formation of different various intermolecular contacts was determined. This made it possible to determine the type of intermolecular interaction and suggest the structures of the complexes \\\\Expert2\\nbo\\Journal of Structural Chemistry\\2009, V. 50, N 6, p.1053.pdf |