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1.
Инвентарный номер: нет.
   

   
    σH-Adducts of 1-alkyl-1,4-diazinium salts as the sources of biradicals in the synthesis of tetraazaphenanthrenes / E. V. Verbitskiy, P. A. Slepukhin, M. A. Ezhikova, M. I. Kodess, Yu. N. Shvachko, D. V. Starichenko, G. L. Rusinov, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2011. - Vol.60, №5. - С. 975-980
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PH-ADDUCTS -- BIRADICALS -- TETRAAZAPHENANTHRENES
Аннотация: O- and C-Adducts of 5-(het)aryl-2,3-dicyano-1-ethylpyrazinium salts are latent sources of biradicals capable of forming tetraazaphenanthrene derivatives via dimerization. The mechanisms of the reactions were examined using ESR spectroscopy. The stereochemistry of the resulting heterocyclic systems was studied by NMR spectroscopy. The crystallographic data on their three-dimensional structures were obtained

\\\\Expert2\\nbo\\Russian Chemical Bulletin\\2011, 60 (5), 975-980.pdf
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2.
Инвентарный номер: нет.
   
   T 82

   
    Transformations of C-adducts of 1,4-diazinium salts with dicarbonyl compounds into polycyclic systems [Electronic resource] / E. V. Verbitskiy, P. A. Slepukhin, G. L. Rusinov, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2008. - Vol. 57, № 3. - P652-656
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: C-Adducts of 5-(het)aryl-2,3-dicyano-1-pyrazinium salts containing a residue of a 1,3-dicarbonyl compound at position 6 can be involved in the cyclization with hydrazine hydrate giving rise to pyrazino[2,3-c]pyridazines along with the expected pyrazole derivatives. The reactions of the same ?H-adducts with hydroxylamine unexpectedly afforded triazacyclopenta[a]indene derivatives. The crystallographic data on the three-dimensional structures of new polycyclic compounds were obtained

\\\\Expert2\\nbo\\Russian Chemical Bulletin\\2008, 57 (3), 652.pdf
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3.
Инвентарный номер: нет.
   
   T 44

   
    The portable detector of nitro-explosives in vapor phase with new sensing elements on a base of pyrimidine scaffold / A. A. Baranova, K. O. Khokhlov, R. D. Chuvashov, E. V. Verbitskiy, E. M. Cheprakova, G. L. Rusinov, V. N. Charushin // Journal of Physics: Conference Series. - 2017. - Vol. 830. - P012159[1-6]
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Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PORTABLE DETECTOR -- NITROEXPLOSIVE -- VAPOR PHASE -- SENSING ELEMENT -- PYRIMIDINE SCAFFOLD -- C(5) MONO(HETEROARYL) -- C(4) MONO(HETEROARYL) -- DI(HETEROARYL) SUBSTITUTED -- PYRIMIDINES -- PYRIMIDINE RING -- VOLATILE INTERFERENT -- NITROSCAN -- TEMPERATURE 293 K TO 298 K
Аннотация: In this paper, the new sensors based on the C(4) or/and C(5) mono(heteroaryl) and di(heteroaryl) substituted pyrimidines are described. The effect of different substituents in pyrimidine ring on the detection limits and selectivity for prepared sensors are explained. The results of detection towards various nitro-explosives and volatile interferents at room temperature with use of the portable detector “Nitroscan” are shown.

\\\\Expert2\\NBO\\Journal of Physics Conference series\\2017 v.830 p.012159.pdf
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4.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis, X-ray crystal structure and antimycobacterial activity of enantiomerically pure 1-ethyl-2,3-dicyano-5-(het)aryl-6-hetaryl-1,6-dihydropyrazines / E. V. Verbitskiy, M. S. Toropova, M. I. Kodess, M. A. Ezhikova, M. I. Isenov, M. G. Pervova, M. A. Kravchenko, I. D. Medvinskiy, S. N. Skornyakov, G. L. Rusinov, V. N. Charushin // ARKIVOC. - 2014. - Pt. V. - С. 247-270
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
X-RAY CRYSTAL -- ANTIMYCOBACTERIAL ACTIVITY -- SYNTHESIS

\\\\expert2\\nbo\\ARKIVOC\\2014, p.247-270.pdf
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5.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis, spectral and electrochemical properties of pyrimidine-containing dyes as photosensitizers for dye-sensitized solar cells [Electronic resource] / E. V. Verbitskiy [и др.] // Dyes and Pigments. - 2014. - Vol.100. - С. 201-214. - Bibliogr. : p. 213-214 (37 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ORGANIC DYES -- PYRIMIDINE -- MICROWAVE-ASSISTED
Аннотация: Six novel donor–π–acceptor organic dyes bearing a pyrimidine as the anchoring group have been obtained in good yields by combination of the microwave-assisted Suzuki cross-coupling and nucleophilic aromatic substitution of hydrogen reactions. Their absorption, photoluminescence and electrochemical properties were fully investigated in detail. The infrared spectra of dyes adsorbed on TiO2 indicate the formation of coordinate bonds between the pyrimidine ring of dyes and the Lewis acid sites (exposed Tin+ cations) of the TiO2 surface. This work demonstrates that the pyrimidine rings of dye sensitizers that form a coordinate bond with the Lewis acid site of a TiO2 surface are promising candidates as the electron-withdrawing anchoring group. The data from quantum calculations show that all of the dyes are potentially good photosensitizers for dye-sensitized solar cells

\\\\expert2\\NBO\\Dyes and Pigments\\2014, v. 100, p.201-214.pdf
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6.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis, Photophysical and Redox Properties of the D-pi-A Type Pyrimidine Dyes Bearing the 9-Phenyl-9H-Carbazole Moiety [Electronic resource] / E. V. Verbitskiy [и др.] // Journal of Fluorescence. - 2015. - Vol. 25, № 3. - С. 763-775. - Bibliogr. : p. 774-775 (51 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINES -- CARBAZOLE -- DYE-SENSITIZED SOLAR CELLS
Аннотация: Novel donor-pi-acceptor dyes bearing the pyrimidine unit as an electron-withdrawing group have been synthesized by using combination of two processes, based on the microwave-assisted Suzuki cross-coupling reaction and nucleophilic aromatic substitution of hydrogen. Spectral properties of the obtained dyes in six aprotic solvents of various polarities have been studied by ultraviolet-visible and fluorescence spectroscopy. In contrast to the absorption spectra, fluorescence emission spectra displayed a strong dependence from their solvent polarities. The nature of the observed long wavelength maxima has been elucidated by means of quantum chemical calculations. The electrochemical properties of these dyes have been investigated by using cyclic voltammetry, while their photovoltaic performance was evaluated by a device fabrication study. The experimental and calculation data show that all of the dyes can be regarded as potentially good photosensitizers for dye-sensitized solar cells.

\\\\expert2\\nbo\\Journal of Fluorescence\\2015, v.25, p.763-775.pdf
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7.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis, crystal structures, and properties of 5-(het)aryl-3-cyano-1-ethyl-2(1H)-pyr / E. V. Verbitskiy, M. V. Berezin, P. A. Slepukhin, O. N. Zabelina, G. L. Rusinov, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2011. - Vol.60, №5. - С. 906-913
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
SYNTHESIS -- PYRAZINONES -- CRYSTAL STRUCTURES
Аннотация: A simple method for the synthesis of 5-(het)aryl-3-cyano-1-ethyl-2(1H)-pyrazinones was proposed. The method is based on the hydrolysis of the corresponding 2,3-dicyanopyrazinium salts. The spectral properties of pyrazinones were studied and their crystallographic investigation was carried out. The possibility of introduction of 5-(het)aryl-3-cyano-1-ethyl-2(1H)-pyrazinones into the [2+4] cycloaddition under the microwave activation conditions was sho

\\\\Expert2\\nbo\\Russian Chemical Bulletin\\2011, 60 (5), 906-913.pdf
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8.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis, antimycobacterial and antifungal evaluation of some new 1-ethyl-5-(hetero)aryl-6-styryl-1,6-dihydropyrazine-2,3-dicarbonitriles [Electronic resource] / E. V. Verbitskiy, P. A. Slepukhin, M. A. Kravchenko, S. N. Skornyakov, N. P. Evstigneeva, N. V. Kungurov, N. V. Zil'berberg, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // Bioorganic and Medicinal Chemistry Letters. - 2015. - Vol. 25, № 3. - С. 524-528. - Bibliogr. : p. 528 (16 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRAZINES -- ANTITUBERCULOSIS ACTIVITY -- PETASIS REACTION
Аннотация: The Petasis reaction of 6-hydroxy adducts of 1-alkyl-2,3-dicyano-5-arylpyrazinium salts with trans-styrylboronic acids proved to proceed smoothly at room temperature to give the corresponding 5-(hetero)aryl-6-styryl substituted 1,6-dihydropyrazine derivatives. Also it has been found that C(6) unsubstituted 1,6-dihydro- or 1,4,5,6-tetrahydropyrazine derivatives can be easy prepared in high yields from the corresponding pyrazinium salts by reduction with triethylsilane. All synthesized compounds were screened in vitro for their antifungal activities against seven pathogenic fungal strains and antimycobacterial activities against Mycobacterium tuberculosis H(37)Rv, avium, terrae and multi-drug-resistant strains isolated from tuberculosis patients in the Ural region (Russia)

\\\\expert2\\nbo\\Bioorganic and Medicinal Chemistry Letters\\2015, v. 25, p. 524.pdf
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9.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis, and structure-activity relationship for C(4) and/or C(5) thienyl substituted pyrimidines, as a new family of antimycobacterial compounds [Electronic resource] / E. V. Verbitskiy, E. M. Cherprakova, P. A. Slepukhin, M. A. Kravchenko, S. N. Skornyakov, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // European Journal of Medicinal Chemisrty. - 2015. - Vol. 96. - С. 225-234. - Bibliogr. : p. 234 (36 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ

\\\\expert2\\nbo\\European Journal of Medicinal Chemistry\\2015, v.96, p.225-234.pdf
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10.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis of novel purin-6-yl conjugates with heterocyclic amines linked via 6-aminohexanoyl fragment [Electronic resource] / E. V. Verbitskiy, E. M. Cheprakova, P. A. Slepukhin, M. A. Kravchenko, S. N. Skornyakov, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // Mendeleev Communications. - 2015. - Vol. 25. - С. 412-414. - Bibliogr. : p. 414 (30 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
2-AMINOPURINE -- PURIN-6-YL -- HETEROCYCLIC AMINES
Аннотация: Novel conjugates of purine and 2-aminopurine linked with heterocyclic amines, including chiral derivatives of 3,4-dihydro- 2H-[1,4]benzoxazine, 3,4-dihydro-2H-[1,4]benzothiazine and 1,2,3,4-tetrahydroquinoline, by 6-aminohexanoyl fragment at the 6-position of purine moiety were obtained. For this purpose, replacement of the chlorine atom in 2-amino-6-chloropurine or 6-chloropurine by direct nucleophilic substitution reaction with 6-aminohexanamides or the coupling of 6-(purin-6-ylamino)-6- hexanoic acid with nitrogen heterocycles were used.

\\\\expert2\\nbo\\Mendeleev Communications\\2015, v.25, p. 412.pdf
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11.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis of new C(4) and/or C(5) thienyl substituted pyrimidines as potential antimycobacterial agents. / E. V. Verbitskiy, E. M. Cheprakova, M. A. Kravchenko, S. N. Skornyakov, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // 19h European Symposium on Organic Chemistry (ESOC-2015), 12th-16th July, Lisboa, Portugal, 2015. : book of abstr. . - Lisboa, 2015. - С. 450
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Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINES -- ANTIMYCOBACTERIAL AGENTS -- SYNTHESIS

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12.
Инвентарный номер: нет.
   

   
    Synthesis of heteroannulated indolopyrazines through domino N-H palladium-catalyzed/metal-free oxidative C-H bond activation / Y. A. Kvashnin, E. V. Verbitskiy, E. F. Zhilina [et al.] // ACS Omega. - 2020. - Vol. 5, № 25. - P15681-15690
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: A convenient approach to [1,2,5]oxadiazolo[3′,4′:5,6]pyrazino[2,3-b]indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald–Hartwig and subsequent annulation by intramolecular oxidative cyclodehydrogenation. The photophysical properties for new polycycles have been measured.

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13.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis of 6-thienyl-substituted 2-amino-3-cyanopyridines [Electronic resource] / E. V. Verbitskiy, E. M. Cheprakova, M. G. Pervova, G. G. Danagulyan, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2015. - С. 689-694. - Bibliogr. : p. 694 (25 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINES -- TRANSFORMATIONS OF HETEROCYCLE -- PYRIDINES
Аннотация: An efficient method for the synthesis of 6-thienyl-substituted 2-amino-3-cyanopyridines by the ring transformation in the corresponding pyrimidines was developed. Further modification of the pyridines obtained under conditions of a room temperature aerobic Suzuki reaction in the presence of trans-bis(dicyclohexylamine) palladium(II) acetate as a catalyst was studied.

\\\\expert2\\nbo\\Russian Chemical Bulletin\\2015, 64 (3), 689-694.pdf
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14.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis and evaluation of antitubercular activity of fluorinated 5-aryl-4-(hetero)aryl substituted pyrimidines [Электронный ресурс] / E. V. Verbitskiy, S. A. Baskakova, M. A. Kravchenko, S. N. Skornyakov, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // Bioorganic and Medicinal Chemistry. - 2016. - Vol. 24, № 16. - С. 3771-3780
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINE -- ANTIMYCOBACTERIAL ACTIVITY -- TUBERCULOSIS
Аннотация: Various 5-(fluoroaryl)-4-(hetero)aryl substituted pyrimidines have been synthesized based on the Suzuki cross-coupling and nucleophilic aromatic substitution of hydrogen (S-N(H)) reactions starting from commercially available 5-bromopyrimidine and their antitubercular activity against Mycobacterium tuberculosis H(37)Rv has been explored. The outcome of the study disclose that, some of the compounds have showed promising activity in micromolar concentration against Mycobacterium tuberculosis H(37)Rv, Mycobacterium avium, Mycobacterium terrae, and multidrug-resistant strains isolated from tuberculosis patients in Ural region (Russia). The data concerning the 'structure-activity' relationship for fluorinated compounds have been discussed

\\\\expert2\\NBO\\Bioorganic and Medicinal Chemistry\\2016, V.24, N 16, p.3771-3780.pdf
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15.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis and characterization of new complexes derived from 4-thienyl substituted pyrimidines [Electronic resource] / E. M. Cherprakova, E. V. Verbitskiy, M. A. Kiskin, G. G. Aleksandrov, P. A. Slepukhin, A. A. Sidorov, D. V. Starichenko, Yu. N. Shvachko, I. L. Eremenko, G. L. Rusinov, V. N. Charushin // Polyhedron. - 2015. - Vol. 100. - С. 89-99. - Bibliogr. : p. 98-99 (42 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINE -- CYCLOPALLADATION -- MAGNETIC-PROPERTIES
Аннотация: The behavior of 4-thienyl substituted pyrimidine ligands (L1-3) has been studied for the series of their reactions with various salts of 3d metals (Co, Zn, Ni, Cu) and platinoids (Pt, Pd). In particular, mononuclear Co(OTf)(2)(L1-3)(2)(H2O)(2)(MeCN)(2) (1), binuclear Co-2(Piv)(2)(L1-3)(4) (2a,b), Cu-2(Piv)(2)(L1-3)(2) (5a,b), heterometallic polynuclear Li2Co2(Piv)(6)(L1-3)(2) (4) and chelate [(L-1)Pd(OAc)](2) (6) complexes have been obtained. The structures of all complexes have been established by X-ray diffraction. Also magnetic properties of coordination compounds 1, 2, 4 and 5 have been studied in details. In particular, mononuclear Co(II) complexes I and 4 proved to exhibit paramagnetism with large positive zero-field splitting parameters. Dinuclear Co(II) complexes 2a,b show weak antiferromagnetic interactions. Dinuclear Cu(II) complexes 5a,b demonstrate strong antiferromagnetic superexchange interactions via four carboxylate bridges. The systems 2a,b and 5a,b are isolated as exchange coupled dimers

\\\\expert2\\nbo\\Polyhedron\\2015, v.100, p.89-99.pdf
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16.
Инвентарный номер: нет.
   

   
    Synthesis and characterization of linear 1,4-diazine-triphenylamine–based selective chemosensors for recognition of nitroaromatic compounds and aliphatic amines / E. V. Verbitskiy, Y. A. Kvashnin, E. F. Zhilina [et al.] // Dyes and pigments. - 2020. - Vol. 178. - P108344
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ALIPHATIC AMINES -- FLUORESCENCE QUENCHING -- NITROAROMATIC COMPOUNDS -- PYRAZINE -- QUINOXALINE -- SOLVATOCHROMISM
Аннотация: Novel 1,4-diazine-based dyes of the D–π–A type, possessing triphenylamine as an electron-donating group, have been developed. Fluorescence studies have demonstrated that emission of these fluorophores is sensitive towards different nitroaromatic compounds and aliphatic amines, both in solutions and in a vapor phase. Moreover, these compounds can be considered as “naked-eye” fluorescent probes for solution polarity because they possess pronounced solvatochromic properties. Therefore, these compounds have to be regarded as potential multifunctional chemosensors for monitoring hazardous organic substances.

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17.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis and biological evaluation of novel 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines as potential anti-bacterial agents / E. V. Verbitskiy [et al.] // Bioorganic and Medicinal Chemistry Letters. - 2017. - Vol. 27, № 13. - P3003-3006
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINE -- NITROFURAN -- ANTIGONORRHEAL -- ANTIMYCOBACTERIAL -- NUCLEOPHILIC AROMATIC SUBSTITUTION OF HYDROGEN
Аннотация: A facile two-step synthetic approach to fluorinated and non-fluorinated 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines from readily available 5-bromo-4-(furan-2-yl)pyrimidine has been developed. All synthesized compounds were screened in vitro for their antibacterial activities against twelve various bacterial strains. It is demonstrated that some of these compounds exhibited significant antibacterial activities against strains Neisseria gonorrhoeae and Staphylococcus aureus, comparable and even higher with that commercial drug Spectinomycin.

\\\\Expert2\\NBO\\Bioorganic and Medicinal Chemistry Letters\\2017 v.27 p.3003-3006.pdf
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18.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis and antituberculosis activity of novel 5-styryl-4-(hetero)aryl-pyrimidines via combination of the Pd-catalyzed Suzuki cross-coupling and SNH reactions [Electronic resource] / M. A. Kravchenko, E. V. Verbitskiy, I. D. Medvinskiy, G. L. Rusinov, V. N. Charushin // Bioorganic and Medicinal Chemistry Letters. - 2014. - Vol. 24, №14. - С. 3118-3120
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINE -- ANTIMICOBACTERIAL -- TUBERCULOSIS
Аннотация: Combination of the Suzuki cross-coupling and nucleophilic aromatic substitution of hydrogen (SNH) reactions proved to be a convenient method for the synthesis of 5-styryl-4-(hetero)aryl substituted pyrimidines from commercially available 5-bromopyrimidine. All intermediate 5-bromo-4-(hetero)aryl substituted pyrimidines and also the targeted 5-styryl-4-(hetero)arylpyrimidines were found to be active in micromolar concentrations in vitro against Mycobacterium tuberculosis H37Rv, avium, terrae, and multi-drug-resistant strain isolated from tuberculosis patients in Ural region (Russia). It has been found that some of these compounds possess a low toxicity and have a bacteriostatic effect, comparable and even higher with that of first-line antituberculosis drugs

\\\\expert2\\nbo\\Bioorganic and Medicinal Chemistry Letters\\2014, v. 24, p. 3118.pdf
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19.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis and Antitubercular Evaluation on Novel 1-Ethyl-5-(hetero)aryl- 1,6-dihydropyrazine-2,3-dicarbonitriles and 3-Cyano-1-ethyl-5-(hetero) aryl-2(1H)-pyrazinones / M. A. Kravchenko, E. V. Verbitskiy, S. N. Skornyakov, P. A. Slepukhin, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // Anti-Infective Agents. - 2016. - Vol. 14, № 2. - С. 139-144
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRAZINES -- ANTITUBERCULOSIS ACTIVITY -- 2(1H)-PYRAZINONE
Аннотация: A simple method based on hydrolysis of 2,3-dicyanopyrazinium salts has been used for the synthesis of the corresponding 5-(hetero)aryl-3-cyano-1-ethyl-2(1H)-pyrazinones. Also, the series of novel 1-ethyl-5-(hetero)aryl-1,6-dihydropyrazine-2,3-dicarbonitriles have been obtained through reduction of the same pyrazinium salts with triethylsilane. The obtained compounds proved to be active in micromolar concentrations in vitro against Mycobacterium tuberculosis H37Rv, Mycobacterium avium, Mycobacterium terrae, as well as against rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis. The data for acute in vivo toxicity in mice have been obtained for these compounds which appear to be promising antitubercular agents

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20.
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   S 98

   
    Synthesis and antimycobacterial activity of enantiomerically pure 1-ethyl-2,3-dicyano-5-(het)aryl-6-hetaryl-1,6-dihydropyrazines / E. V. Verbitskiy, M. A. Kravchenko, I. D. Medvinskiy, G. L. Rusinov, V. N. Charushin // Уральский научный форум "Современные проблемы органической химии". XVII Молодежная школа-конф. по органической химии, Екатернинбург, 8-12 июня 2014 г. : сб. тез. - Екатеринбург, 2014. - С. 48
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
SYNTHESIS -- ANTIMICOBACTERIAL ACTIVITY

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