H 19 Halogenation of fluorinated 1,3,5-triketones [Text] / D. V. Sevenard, O. Kazakova, D. L. Chizhov, D. S. Yachevskii, E. Lork, J. Poveleit, V. N. Charushin, G. -V. Roeschenthaler // Helvetica Chimica Acta. - 2007. - Vol. 90, № 2. - P369-384. - Библиогр. : с. 384 (17 назв.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The behavior of linear and cyclic fluorinated 1,3,5-triketones and their metal derivatives towards common halogenating agents was examined, and optimal reaction conditions for the straightforward synthesis of mono-, di-, and tetrahalogenated products were found (Schemes 1-3). An aromatization through a double HBr elimination from an ,-dibrominated cyclohexanone was shown to be a promising synthetic route to 1,1-(2-hydroxy-1,3-phenylene)bis[2,2,2-trifluoroethanones] (= 2,6-bis(trifluoroacetyl)phenols; Scheme 4). Additionally, the 1,3,5-triketones prepared add readily H2O or alcohols to produce novel bridged 2,6-dihydroxypyran-4-ones (Scheme 2). The structure of the obtained compounds 6a and 7a was confirmed by X-ray structure analysis. \\\\expert2\\nbo\\Helvetica Chimica Acta\\2007. V. 90. P. 369.pdf |
R 59 Ring-chain transformations of dihydroisoxazolo[4,5-b]quinoxaline [Electronic resource] / A. M. Boguslavskii, M. G. Ponizovskii, M. I. Kodess, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2005. - Vol. 41, № 9. - P1377-1380. - Библиогр. : с. 1380 (18 назв.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Ring-chain transformation of 3-hydroxyiminomethyl-1-methylquinoxalinium iodide into 9-methyl-9,9a-dihydroisoxazolo[4,5- b]quinoxaline was studied. The isoxazole ring in the latter was cleaved by the action of alcohols. \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2005, 41 (9), 1377.pdf |
E 43 Electrochemical sensor based on metal-containing receptors for urea measurements [Text] : доклад, тезисы доклада / A. Kozitsina [и др.] // International Congress on Analytical Sciences "ICAS - 2006",M., June 25-30 2006 : book of abstracts. - М., 2006. - Vol. 1. - P291 : табл. - Bibliogr. : p. 291 (1 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ |
C 98 Cyclization of N-alkylazinium cations with bifunctional nucleophiles. 16. σ-adducts of quinoxalinium salts with amines, alcohols, and enolates and their role in cyclizations with β-dicarbonyl compounds [Electronic resource] / V. N. Charushin, M. G. Ponizovskii, O. N. Chupakhin, E. O. Sidorov, I. M. Sosonkin // Chemistry of Heterocyclic Compounds. - 1985. - Vol. 21, № 5. - С. 564-572. - Bibliogr. : p. 571-572 (16 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ACETYLACETONE -- 1H NMR SPECTROSCOPY -- N-METHYLQUINOXALINIUM CATION Аннотация: In the reaction of N-methylquinoxalinium iodide with acetylacetone at −30 °C, the formation of 3-acetyl-2,4-dimethyl-3a,4,9,9a-tetrahydrofuro[2,3-b]quinoxaline has been recorded by 1H NMR spectroscopy, this being a regioisomer of the 3-acetyl-2,9-dimethyl-3a,4,9,9a-tetrahydro[2,3-b]quinoxaline formed in this reaction at temperatures above −10 °C. σ-Adducts of the N-methylquinoxalinium cation with alcohols, amines, and β-diketones have also been identified, and their role in cyclizations leading to the annelation of a furan ring is discussed. \\\\expert2\\nbo\\Chemistry of Heterocyclic Compounds\\1985, v.21, N 5, p. 564.pdf |
I-55 Imidazoline ring cleavage in 1,3,6,10-tetraazatetracyclo-[7.3.1.02,7.06,13]trideca-4, 11-dienes, leading to the formation of diquinoxalino[1,2-a∶2′,3′-d]pyrrole derivatives [Electronic resource] / V. N. Charushin, G. M. Petrova, G. G. Aleksandrov, L. G. Egorova, A. I. Chernyshev, E. O. Sidorov, N. A. Klyuev, O. N. Chupakhin // Chemistry of Heterocyclic Compounds. - 1987. - Vol. 23, № 4. - С. 426-435. - Bibliogr. : p. 435 (9 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): CARBON ATOM -- ALCOHOLS -- THIOLS Аннотация: Dibenzo[d,k]-1,3,6,10-tetraazatetracyclo[7.3.1.02,7.06,13]trideca-4,11-dienes undergo addition reactions at the C(2) carbon atom with alcohols and thiols, accompanied by cleavage of the C-N bond of the imidazoline ring, to generate diquinoxalino[1,2-a∶2′,3′-d]pyrrole derivatives. \\\\expert2\\nbo\\Chemistry of Heterocyclic Compounds\\1987, v.23, N 4, p. 426.pdf |
Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity / A. V. Korotina, S. G. Tolshchina, R. I. Ishmetova [et al.] // Beilstein Journal of Organic Chemistry. - 2022. - Vol. 18. - P243-250 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A series of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines has been synthesized through oxidation reaction of the corresponding 3,6-disubstituted 1,2,4,5-tetrazines bearing amidine fragments. It is shown that the heterocyclic systems obtained can be modified easily at C(3) position in the reactions with aliphatic alcohols and amines. Also, the reactivity of [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines towards CH-active compounds has been studied. The obtained triazolo[1,5-b]annulated 1,2,4,5-tetrazines proved to be active in micromolar concentrations in vitro against filamentous anthropophilic and zooanthropophilic dermatophyte fungi (Trichophyton, Microsporum and Epidermofiton), which cause skin and its appendages (hair, nails) diseases. |