С 38 Синтез фторсодержащих аналогов эллиптицина и других гетероциклов на омнове 2-нитро- и 2-амино-4.5-дифторанилинов [] = Synthesis of fluorine-containing analogs of ellipticine and other heterocycles from 2-nitro- and 2-amino-4,5-difluoroanilines / В. Н. Яровенко, А. В. Полушина, К. С. Левченко, И. В. Заварзин, М. М. Краюшкин, С. К. Котовская, В. Н. Чарушин> // Журнал органической химии. - 2007. - Т. 43, Вып. 9. - С. 1391-1396 : рис., табл. - Библиогр. : с. 1396 (12 назв.) . - ISSN 0514-7492 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
F 70 Fluorinated lithium 1,3-diketonates as reagents to modify podands and crown-ethers [Electronic resource] / N. S. Boltacheva, O. V. Fedorova, I. G. Ovchinnikova, O. N. Kazheva, A. N. Chekhlov, O. A. Dyachenko, G. L. Rusinov, V. I. Filyakova, V. N. Charushin> // Journal of Fluorine Chemistry. - 2007. - Vol. 128, № 7. - P762-768 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Fluorinated enaminoketones, a new type of ligands, bearing two independent coordination centers (polyether's and fluorinated enaminoketones fragments) have been obtained. The crystal structure of the Cu(II) complex of 1,5-bis-[2-(4`,4`,4`-trifluoro-1`-methyl-3`oxo-but-1`-enylamino)-phenoxy]-3-oxapentane (10) has been elucidated by X-ray crystallography. The results obtained show that the complex 10 consists of two crystallographically independent molecules C26H24CuF6N2O5 (A and B), and the metal atom in the complex 10 has four-coordinated arrangement, as a polyhedron with a distorted square with two nitrogen and two oxygen atoms located in corners. \\\\expert2\\nbo\\Journal of Fluorine Chemistry\\2007, v.128. p.762.pdf |
S 98 Synthesis and antiviral activity of fluorinated 3-phenyl-1,2,4-benzotriazines [Electronic resource] / S. K. Kotovskaya, G. A. Zhumabaeva, N. M. Perova, Z. M. Baskakova, V. N. Charushin, O. N. Chupakhin, E. F. Belanov, N. I. Bormotov, S. M. Balakhnin, O. A. Serova> // Pharmaceutical Chemistry Journal. - 2007. - Vol. 41, № 2. - P62-68. - Библиогр. : с. 68 (18 назв.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: New synthetic approaches to fluorinated 3-phenyl-1,2,4-benzotriazines for biological testing have been elaborated. 1-(3,4-Difluorophenyl)-3,5-diphenylformazan (IVa) was synthesized via dinitriding of 3,4-difluoroaniline, followed by azo-addition of the resulting azobenzenediazonium chloride with acetaldehyde phenylhydrazone. 6,7-Difluoro-3-phenyl-1,2,4-benzotriazine (Va) was obtained via intramolecular cyclization of formazan IVa in the presence of BF3/AcOH complex. Monofluoro-substituted 6-R-7-fluoro-3-phenyl-1,2,4-benzotriazine derivatives (Vb-Vq) were prepared by substituting fluorine atom with alkoxides in 3,4-difluoronitrobenzene. Conditions for nucleophilic substitution of the second fluorine atom in benzotriazines V have been established. Fluorinated 3-phenyl-1,2,4-benzotriazines have been tested for antiviral and cytotoxic activity on Vero cell cultures and proved to be active against severe diseases caused by smallpox and some other pathogenic viruses. ?? \\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2007, 41 (2), 62.pdf |
A 10 A new approach to fluorinated 4(1H)-quinazolinones [Electronic resource] / A. A. Layeva, E. V. Nosova, G. N. Lipunova, T. V. Trashakhova, V. N. Charushin> // Journal of Fluorine Chemistry. - 2007. - Vol. 128, № 7. - P748-754 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A new approach for the synthesis of fluorinated 1H-quinazolin-4-ones and 4-substituted quinazolines has been developed. 6-Fluoro-1H-quinazolin-4-ones were obtained by intramolecular cyclization of fluorine-containing S-ethyl N-benzoylisothioureas. Nucleophilic substitution reactions at positions 2 and 7, as well as alkylation at 1-position of quinazolinones were investigated. In addition, the synthesis of fluorine-containing 4-aminoquinazolines was carried out. \\\\Expert2\\nbo\\Journal of Fluorine Chemistry\\2007, v.128. p.748.pdf |
F 70 Fluorine-containing heterocycles. XV. Reactions of polyfluorobenzoyl isothiocyanates with amino azines and amino azoles [Electronic resource] / E. V. Nosova, G. N. Lipunova, A. A. Laeva, V. N. Charushin> // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2006. - Vol. 42, № 10. - P1544-1550. - Библиогр. : с. 1550 (9 назв.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Reactions of tetra-and pentafluorobenzoyl isothiocyanates with aminoazoles and aminoazines led to the formation of fluorinated 1,3-benzothiazin-4-ones which reacted with cyclic amines in different ways. Replacement of the N=C=S fragment was observed in some reactions of polyfluorobenzoyl isothiocyanates with nucleophiles. \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2006, 42 (10), 1544.pdf |
5(6)-Fluoro-6(5)-R-benzofuroxans: synthesis and NMR 1H, 13C and 19F studies [Text] / S. K. Kotovskaya, S. A. Romanova, V. N. Charushin, M. I. Kodess, O. N. Chupakhin> // Journal of Fluorine Chemistry. - 2004. - Vol. 125, № 3. - P421-428 : ил. - Библиогр.: с. 428 (14 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): 5,6-DIFLUOROBENZOFUROXAN -- NUCLEOPHILIC SUBSTITUTION -- X-RAY CRYSTALLOGRAPHY Аннотация: 5(6)-Fluoro-6(5)-substituted benzofuroxans were obtained by the reactions of 5,6-difluorobenzofuroxan with a number of nucleophiles, such as alkylamines, cycloalkylimines, sodium azide and sodium alkoxides. The features of tautomerism in the series of asymmetrical 5(6)-fluorobenzofuroxans in acetone solutions have been studied by 1H, 13C and 19F NMR.???? \\\\Expert2\\nbo\\Journal of Fluorine Chemistry\\2004, v.125, p.421.pdf |
F 98 Fused fluoroquinolones: synthesis and 1H and 19F NMR studies [Text] / V. N. Charushin, E. V. Nosova, G. N. Lipunova, M. I. Kodess> // Journal of Fluorine Chemistry. - 2001. - Vol. 110, № 1. - P25-30. - Bibliogr. : p. 30 (19 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: New derivatives of fused fluoroquinolones bearing five aromatic rings have been obtained. The 19F NMR spectra of these pentacyclic fluoroquinolones demonstrate unusual through space 1H–19F and 19F–19F spin–spin interactions with coupling constants 6J(F, H)=2.0–3.0 Hz, 7J(F, F)=3.5–4.0 Hz and 9J(F, H)=3.0–3.5 Hz. Relative reactivities of fluorine atoms in pentacyclic fluoroquinolones in the amino-defluorination reactions are also different relative to bi- and tricyclic fluoroquinolones \\\\Expert2\\nbo\\Journal of Fluorine Chemistry\\2001.v.110. p. 25.pdf |
C 47 Charushin, V. N. Nucleophilic substitutions in 6,7-difluoroquinoxalines [Text] / V. N. Charushin, G. A. Mokrushina, A. V. Tkachev> // Journal of Fluorine Chemistry. - 2001. - Vol. 107, № 1. - P71-80. - Bibliogr. : p. 80 (16 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The reactions of 6,7-difluoroquinoxalines with a number of nucleophiles, such as cycloalkylimines, hydrazine, sodium hydroxide and alkoxides have been shown to result in substitution of either one or two fluoro atoms depending on the nature of nucleophiles \\\\Expert2\\nbo\\Journal of Fluorine Chemistry\\2001.v.107. p. 71.pdf |
P 99 Pyrido[2,3-b]- and pyrimido[4,5-b]quinoxalines: the first fluorine-containing derivatives [Electronic resource] / V. N. Charushin, S. K. Kotovskaya, N. M. Perova, O. N. Chupakhin> // Mendeleev Communications. - 2001. - Vol. 11, № 2. - P54-55 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Fluorinated derivatives of pyrido[2,3-b]- and pyrimido[4,5-b]quinoxalines 5–8 have been prepared through the condensation of 2-amino-3-cyano- and 2-amino-3-aminocarbonyl-substituted 6-fluoro-7-R-quinoxalines 1–4 with dimethyl acetylenedicarboxylate and triethyl orthoformate, respectively?????? \\\\expert2\\nbo\\Mendeleev Communications\\2001, v.11, N 2. p.54.pdf |
C 52 Chizhov, D. L. Convenient Rout to Regioisomeric Fluorinated Keto-Phosphonic Acids [Text] : доклад, тезисы доклада / D. L. Chizhov, V. N. Charushin, G. -V. Roeschenthaler> // 18th ISFC international Symposium on Fluorine Chemistry. Bremen, 30th Jul.-4 Aug. 2006 г. : Final Program. Abstracts. - Bremen, 2006. - P260 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): KETO-PHOSPHONIC -- HYDROLYSIS |
H 19 Halogenation of Fluorinated 1,3-Dicarbonyl and 1,3,5-Tricarbonyl Compounds [Text] : доклад, тезисы доклада / D. V. Sevenard [и др.]> // 18th ISFC international Symposium on Fluorine Chemistry. Bremen, 30th Jul.-4 Aug. 2006 г. : Final Program. Abstracts. - Bremen, 2006. - P271 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): HALOGEN -- HALOGENATION AGENTS |
R 30 Reaction of Polyhaloalkyl-Substituted Chromones, Pyrones, and Furanones with Salicylaldehydes as a Direct Route to Fused 2H-Chromenes [Text] : доклад, тезисы доклада / V. Ya. Sosnovskikh, V. Yu. Korotaev, D. L. Chizhov, I. B. Kutyashev, D. S. Yachevskii, V. N. Charushin> // 18th ISFC international Symposium on Fluorine Chemistry. Bremen, 30th Jul.-4 Aug. 2006 г. : Final Program. Abstracts. - Bremen, 2006. - P307 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): GAMMA-RYRONES -- BETA-FURANONES |
N 89 Novel fluorine-containing enaminoketones modifed by podandes and crown ethers [Text] : доклад, тезисы доклада / V. I. Filyakova, N. S. Boltacheva, O. V. Fedorova, I. G. Ovchinnikova, G. L. Rusinov, V. N. Charushin, O. N. Kazheva, A. N. Chekhlov, O. A. Dyachenko> // 18th ISFC international Symposium on Fluorine Chemistry. Bremen, 30th Jul.-4 Aug. 2006 г. : Final Program. Abstracts. - Bremen, 2006. - P328 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ENAMINOKETONE -- LITHIUM |
S 98 Synthesis of fluorineted heterocycles on the basis of regioisomeric enaminoketones [Text] : доклад, тезисы доклада / V. I. Filyakova, O. P. Krasnykh, N. S. Boltacheva, O. A. Kuznetsova, V. N. Charushin> // 15th European symposium on fluorine chemistry, Prague, Czech Republic, July 15-20, 2007 : abstr. - 2007. - P201 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): FLUORINETED HETEROCYCLES -- REGIOISOMERIC ENAMINOKETONES |
N 52 New podandes and crown ethers nodified with the fragments of fluorinated pyrazolines [Text] : доклад, тезисы доклада / V. I. Filyakova, E. B. Letova, N. S. Boltacheva, P. A. Slepukhin, V. N. Charushin> // 15th European symposium on fluorine chemistry, Prague, Czech Republic, July 15-20, 2007 : abstr. - 2007. - P202 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): FLUORINATED PYRAZOLINES |
F 52 Filyakova, V. I. Unusual transformation of trifluoroacetylacetone [Text] : доклад, тезисы доклада / V. I. Filyakova, P. A. Slepukhin, V. N. Charushin> // 15th European symposium on fluorine chemistry, Prague, Czech Republic, July 15-20, 2007 : abstr. - 2007. - P203 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): TRIFLUOROACETYLACETONE |
F 70 Fluorine-containing heterocycles. XVII. (Tetrafluorobrnzoyl)thioureas in the synthesis of fluorine-containing azaheterocycles [Electronic resource] / G. N. Lipunova, E. V. Nosova, A. A. Laeva, T. V. Trashakhova, P. A. Slepukhin, V. N. Charushin> // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2008. - Vol. 44, № 5. - P741-749 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Proceeding from (tetrafluorobenzoyl)thioureas fluorine-containing derivatives were synthesized of 1-aryl-2-ethylthioquinazolin-4-one, [1,3]benzothiazin-4-one, and also of thiazolidine and 1H-1,2,4-triazole \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2008, 44 (5), 741.pdf |
F 70 Fluorine-containing Heterocycles. XI. 5(6)-Fluoro-6(5)-X-benzofuroxans: Synthesis, Tautomerism, and Transformations [Electronic resource] / O. N. Chupakhin, S. K. Kotovskaya, S. A. Romanova, V. N. Charushin> // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2004. - Vol. 40, № 8. - P1167-1174 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Features of 5(6)-fluoro-6(5)-X-benzofuroxans tautomerism were investigated. By 1H, 13C, and 19F NMR spectroscopy the direction of Boulton-Katritzky rearrangement in nitration, nitrosation, and azo coupling of fluorine-containing furoxanes was determined \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2004, 40 (8), 1167.pdf |
F 70 Fluorine-Containing Heterocycles. VII. Nucleophilic Substitution in 6,7-Difluoroquinoxalines [Electronic resource] / S. K. Kotovskaya, S. A. Romanova, V. N. Charushin, O. N. Chupakhin> // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2002. - Vol. 38, № 7. - P1046-1052 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: For the purpose of biological screening, a number of new quinoxalines have been synthesized via fluorine replacement in 2,3-disubstituted 6,7-difluoroquinoxaline 1,4-dioxides and their deoxygenated derivatives by reactions with dialkylamines, sodium azide, and sodium methoxide \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2002, 38 (7), 1046.pdf |
F 70 Fluorine-containing heterocycles. XVI. Reactions of tetrafluorobenzoyl isothiocyanate with hydrazines and their derivatives [Electronic resource] / E. V. Nosova, G. N. Lipunova, A. A. Laeva, L. P. Sidorova, V. N. Charushin> // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2007. - Vol. 43, № 1. - P68-76 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Fluorinated derivatives of 4H-1,3-benzothiazin-4-one, [1,2,4]triazolo[4,3-a]pyrimidine, [1,2,4]triazolo[3,4-b][1,3]benzazoles, and 1,5-dihydro-1,2,4-triazole-5-thione were synthesized by addition of hydrazines and their derivatives to tetrafluorobenzoyl isothiocyanate, followed by cyclization of intermediate thiosemicarbazides \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2007, 43 (1), 68.pdf |