F 70 Fluoro-containing Heterocycles. IV. Synthesis of Benzimidazole Derivatives [Electronic resource] / S. K. Kotovskaya, N. M. Perova, Z. M. Baskakova, S. A. Romanova, V. N. Charushin, O. N. Chupakhin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2001. - Vol. 37, № 4. - P564-569 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: 2-Mercapto-5,6-difluorobenzimidazole reacts with aliphatic and alicyclic ketones in acetic acid in the presence of catalytic amount of sulfuric acid to afford fluorinated derivatives of 2,3-disubstituted benz[4,5]imidazo[2,1-b][1,3]thiazoles. Reaction with aromatic -haloketones occurs in another way: to furnish 2-phenylacylthio-5,6-difluorobenzimidazoles that in the system acetic anhydride-pyridine undergo cyclization into the corresponding fluorinated derivatives of benz[4,5]imidazo[2,1-b][1,3]thiazoles \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2001, 37 (4), 564.pdf |
S 98 Synthesis of dihydrothiazoles and thiazoles based on monothiooxamides [Text] / V. N. Yarovenko, A. V. Polushina, I. V. Zavarzin, M. M. Krayushkin, S. K. Kotovskaya, V. N. Charushin // Journal of Sulfur Chemistry. - 2009. - Vol. 30, № 3-4. - P327-337 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Dihydrothiazoles and thiazoles were synthesized by the reaction of monothiooxamides containing allylamine and propargylamine fragments with halogens in ionic liquids \\\\expert2\\nbo\\Journal of Sulfur Chemistry\\2009. V. 30, N 3-46. P. 327-337.pdf |
F 70 Fluorinated derivatives of benz[4,5]imidazo[2,1-b][1,3]thiazoles are inhibitors of measles viruses [Электронный ресурс] / A. G. Pokrovskii, E. A. Il"ichyova, S. K. Kotovskaya, S. A. Romanova, V. N. Charushin, O. N. Chupakhin // Doklady Akademii Nauk . - 2004. - Vol.398, №3. - P412-414 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ANTIVIRAL ACTIVITY -- CYTOTOXICITY -- FLUORINATED BENZIMIDAZOLES Аннотация: The results of in vitro anti-virus activity investigation for the new benzimidazoles (their synthesis is reported previously) are presented. The activity of the most active compound was studied in dependence of its introduction to the culture (before virus adsorption, simultaneously with virus, directly after virus adsorption, after 6 hours and after 1 day). Preliminary treatment of cells didn't protect them from further infecting; therewith the compound introduction simultaneously with virus or after infection caused no considerable effect on its anti-virus activity. The latter is attributed to blocking of late stages of measles virus reproduction - synthesis or arrangement of virus proteins |
F 70 Fluorinated derivatives of Benz[4,5]imidazo[1,2-b][1,3] thiazole - Inhibitors of reproduction of measles virus [Электронный ресурс] / A. G. Pokrovskii, E. A. Il"ichyova, S. K. Kotovskaya, S. A. Romanova, V. N. Charushin, O. N. Chupakhin // Doklady Biochemistry and Biophysics . - 2004. - Vol.398, №1-6. - P285-287 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): RIBAVIRIN -- ANTIVIRAL AGENTS -- THIAZOLES |