Compression of molecules is a means to control their conformations and modify their ionization potentials and electron affinity by violation of atomic orbitals and their inter- and intra-molecular potentials. Compression induced modification of the vibrational frequencies increases the difference of zero point energies of isotopic molecules, which results to increasing isotope effects. By compression of single crystals the reaction trajectories of hydrogen atom transfer were identified. Compression is a means for the key, Life supporting enzymes, ATP synthase and DNA polymerase, to function as the molecular devices, overcoming high energy repulsive barrier and urging ATP and DNA synthesis. By using nuclear magnetic ions of magnesium, calcium, and zinc, catalyzing enzymatic ATP and DNA synthesis, the new radical pair mechanism is discovered. It is induced by compression of enzymatic sites and strongly, by 3–5 times, suppresses DNA synthesis and even more strongly, by 30–50 times, increases mortality of cancer cells. In this case compression of enzymatic sites dehydrates metal ions, stimulating electron transfer and switching on radical pair mechanism, responsible for the magnetic control of gene chemistry and magneto-biology.