The phospholipid composition and generalized parameters of lipid metabolism in CBA mice liver were studied in a month after the end exposure. The mice were treated during 1 month with different nature factors: the chronic low intensity γ-irradiation at low doze (1.44-1.60 cGy), lead and sodium nitrate (0.1g/kg). High-sensitivity of parameters studied was shown. The phospholipid composition and lipid metabolism parameters were changed most of all in case of low intensity y- irradiation and sodium nitrate separate actions. Some normalization in the phospholipid compo¬sition of mice liver was found in case of combined effect of irradiation and lead nitrate or sodium nitrate, but analysis of generalized parameters indicated the harmful effect preservation.