A series of 6-fluoroaryl substituted [l,2,4]triazolo[l,5-a]pyrimidines have been synthesized by using the microwave-assisted Suzuki cross-coupling reaction from readily available 6-bromo-[l,2,4]triazolo[l,5-a]pyrimidine. The antimicrobial activity of new compounds has been evaluated in vitro against Mycobacterium tuberculosis H37RV and gram-negative (Neisseria gonorrhoeae ATCC 49226) bacteria.