New approach to biologically active indolo[2,3-b]quinoxaline derivatives through intramolecular oxidative cyclodehydrogenation

New approach to biologically active indolo[2,3-b]quinoxaline derivatives through intramolecular oxidative cyclodehydrogenation / G. Sadykhov, D. V. Belyaev, M. G. Pervova [et al.] // ChemistrySelect. - 2022. - Vol. 7, № 18. - P. e202200497.

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Год:

2022

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Аннотация

A convenient synthetic protocol to antiviral agent B-220 and a series of similar indolo[2,3-b]quinoxaline derivatives has been developed. This synthetic approach is based on Buchwald-Hartwig cross-coupling and subsequent annulation by intramolecular oxidative cyclodehydrogenation. For the first time, 6H-indolo[2,3-b]quinoxaline amine derivatives were evaluated for antimycobacterial activity. The moderate bacteriostatic effect against Mycobacterium tuberculosis H37Rv was found. A plausible mechanism of antibacterial action was elucidated by the molecular docking.