Нарушения в технологии кормления и содержания высокопродуктивные животных сопровождаются увеличением метаболической нагрузки на их организм и негативно сказываются на функциональном состоянии печени. Несмотря на значительный интерес к иммунологической роли печени, особенности иммунного профиля коров при патологиях гепатобилиарной системы остаются недостаточно изученными. Цель исследования - выявить особенности иммунного профиля коров при патологиях печени. Исследования проводили на коровах 2-3 лактации голштинской породы. Ретроспективно сформировали 2 группы: 1 - животные без признаков нарушений функции печени (п=20); 2 - животные с признаками нарушения функции печени (п=20). Установлено, что у животных с патологией печени относительное содержания сегментоядерных нейтрофилов и Т-лимфоцитов выше, относительное содержание лимфоцитов и фагоцитарная активность ниже, чем у здоровых коров. Повышение иммунорегуляторного индекса отражало смещение иммунного баланса в сторону клеточных реакций. Результаты исследования указывают на функциональное истощение врожденного иммунитета и усиление клеточного иммунного ответа у коров с хроническим воспалением. Эти изменения могут снижать эффективность вакцинопрофиViolations in the technology of feeding and keeping highly productive animals are accompanied by an increase in the metabolic load on their body and negatively affect the functional state of the liver. Despite significant interest in the immunological role of the liver, the features of the immune profile of cows with pathologies of the hepatobiliary system remain insufficiently studied. The aim of the study was to identify the features of the immune profile of cows with liver pathologies. The studies were conducted on cows of the 2nd-3rd lactation of the Holstein breed. Retrospectively, 2 groups were formed: 1 - animals without signs of liver dysfunction (n = 20); 2 -animals with signs of liver dysfunction (n = 20). It was found that in animals with liver pathology, the relative content of segmented neutrophils and T-lymphocytes is higher, the relative content of lymphocytes and phagocytic activity is lower
лактики инфекционных заболеваний животных.
Violations in the technology of feeding and keeping highly productive animals are accompanied by an increase in the metabolic load on their body and negatively affect the functional state of the liver. Despite significant interest in the immunological role of the liver, the features of the immune profile of cows with pathologies of the hepatobiliary system remain insufficiently studied. The aim of the study was to identify the features of the immune profile of cows with liver pathologies. The studies were conducted on cows of the 2nd-3rd lactation of the Holstein breed. Retrospectively, 2 groups were formed: 1 - animals without signs of liver dysfunction (n = 20); 2 -animals with signs of liver dysfunction (n = 20). It was found that in animals with liver pathology, the relative content of segmented neutrophils and T-lymphocytes is higher, the relative content of lymphocytes and phagocytic activity is lower than in healthy cows. An increase in the immunoregulatory index reflected a shift in the immune balance towards cellular reactions. The results of the study indicate functional depletion of innate immunity and increased cellular immune response in cows with chronic inflammation. These changes may reduce the effectiveness of vaccination against infectious diseases in animals.
