Synthesis and Antibacterial and Antifungal Activity of 3-(Azol-1-Yl)-6-R-1,2,4,5-Tetrazine

Synthesis and Antibacterial and Antifungal Activity of 3-(Azol-1-Yl)-6-R-1,2,4,5-Tetrazines / R. I. Ishmetova, I. A. Belyaninova, N. K. Ignatenko [et al.] // Pharmaceutical Chemistry Journal. – 2020. – Vol. 53, No. 10. – P. 899-904.

Документ доступен в ЦНБ УрО РАН: 

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Год: 

2020

Связанные персоналии: 

Нет

Рубрики: 

  • Химические науки

Вид издания: 

  • статья из журнала

Коллекции:
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Аннотация

Аннотация

Nucleophilic substitution and 1,3-dipolar cycloaddition reactions were used to synthesize 3,6-disubstituted derivatives of simm-tetrazine containing azolyl, aminoalkyl, and oxyalkyl fragments. The antibacterial activity of the resulting compounds was studied using the obligate pathogen Neisseria gonorrhoeae and opportunistic pathogenic microorganisms, while antifungal activity was assessed using anthropo- and zooanthropophilic dermatophytes.