The study of the effect of novel native immune modulator profetal (alpha fetoprotein as an active substance) on the course of traumatic inflammation and reparative processes has been made with experimental biological model of eye penetrating wound in 91 Wistar male rats. Histological and morphometric methods were used in this work. Profetal was applied both single and in combination with conventional therapy, including glucocorticoids, antibiotics, and non steroid anti inflammatory preparations. It was determined that the use of profetal both as monotherapeutic variant and in combined treatment suppressed the development of wound scarring and induced the processes of tissue defect recovery via reparative regeneration.