Microwave-assisted synthesis and evaluation of antibacterial activity of novel 6-fluoroaryl-[1,2,4]triazolo[1,5-a]pyrimidines

Microwave-assisted synthesis and evaluation of antibacterial activity of novel 6-fluoroaryl-[1,2,4]triazolo[1,5-a]pyrimidines. [Текст] / E. V. Verbitskiy [и др.] // ARKIVOC. - 2016. - Vol. V. - С. 268-278. - Bibliogr. : p. 276-278 (28 ref.).

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Год:

2016

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Аннотация

A series of 6-fluoroaryl substituted [l,2,4]triazolo[l,5-a]pyrimidines have been synthesized by using the microwave-assisted Suzuki cross-coupling reaction from readily available 6-bromo-[l,2,4]triazolo[l,5-a]pyrimidine. The antimicrobial activity of new compounds has been evaluated in vitro against Mycobacterium tuberculosis H37RV and gram-negative (Neisseria gonorrhoeae ATCC 49226) bacteria.