Sepsis is a still-urgent problem of the day. This pathology has been tightly bounded with life-threatening multiple organ dysfunction and a required intensive care by the newest sepsis criteria (“Sepsis-3”, 2016). Experts on the consensus highlighted that no gold standard diagnostic test existed as well as a consistent pathogenetic sepsis image. Sepsis pathogenesis is traditionally regarded as numerous dysregulated proinflammatory mechanisms and secondary changes in many organs, mediated by cause-effect relationships with the mechanisms on the system level by vicious circle type. The Common Pathological Process model is the theoretic basis and simultaneously the fundamental image of any pathology. The inflammation is the integral pathological process. A development of human critical state both of septic (sepsis and septic shock) and aseptic origin could not be though described from the “classical” conception of inflammatory process. A necessity to design the principal model and the methodology of verification of Systemic Inflammation (SI) as the common pathological process that differs from the classical inflammation according to many fundamental characteristics has arisen. We estimated the systemic inflammation from the common pathological process position, but not as a syndrome or another clinical definition, with an integral Sl-scale. The both of differentiated and integral detection of systemic inflammatory response levels as well as a number of particular pathological components of SI complex-process were included into assessment. 207 patients with sepsis were studied. The Systemic Inflammation was registered only in patients under high risk of lethal outcome and development of shock. Septic shock can be considered as an absolute clinic manifestation of SI (3 tables, bibliography: 12 refs).