α-Fetoprotein influence on the conversion of naϊve T-helpers into memory T-cell effector subpopulations

α-Fetoprotein influence on the conversion of naϊve T-helpers into memory T-cell effector subpopulations / S. A. Zamorina, V. P. Timganova, M. S. Bochkova [et al.] // Doklady Biological Sciences. - 2018. - Vol. 482, № 1. - P. 210-213.

Документ доступен в ЦНБ УрО РАН:

Нет

Год:

2018

Связанные персоналии:

Нет

Вид издания:

статья из журнала

Коллекции:

Нет

h1

Публичные страницы

Сканированный текст не найден

Аннотация

The effect of native α-fetoprotein (AFP) on the conversion of naive T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (ТЕМ) and terminally differentiated (TEMRA) memory T-cells was studied. AFP was found to prevent the conversion of naive T-helpers into effector subpopulations of memory T cells (ТЕМ and TEMRA) while reducing the total production of IL-4 and IFN-γ by the studied cell populations. The data reveal a new role of AFP in the immune tolerance formation during pregnancy.