GADD45 genes are involved in the stress response by cell cycle control, DNA repair and apoptosis. We have studied the influence of D-GADD45 overexpression in the nervous system of Drosophila melanogaster on the lifespan and fecundity, and the effect of various doses of ionizing radiation on these parameters. Flies were divided into four groups, specifically, a control group, a group exposed to 60 cGy dose at preimaginal stages, a group exposed to 30 Gy dose since imago and a group exposed to both doses in succession. It is shown that D-GADD45 overexpression in the nervous system significantly increases Drosophila lifespan and fecundity, however is not sufficient for the enhancement of ionizing irradiation resistance.