The study of the effect of novel native immune modulator profetal (alphafetoprotein) as an active substance on the course of traumatic inflammation and reparative processes has been performed with experimental-biological model of penetrating wound of the eye in 36 Wistar rats. Histological and morphometric methods were used in this work. Profetal was applied alone and in combination with conventional therapy including glucocorticoids, antibiotics and non-steroid anti-inflammatory preparations. It was determined that the use of profetal both as monotherapeutic variant and in combined treatment suppressed the development of wound scarring and induced the processes of tissue defect recovery via reparative regeneration.