The principal problem of mining at the Verkhnekamskoye potash deposit is maintaining integrity of the waterproof stratum which protects mines against flooding. Seismic monitoring is one of the techniques routinely used in the mines to understand the response of the rock mass to the extraction of ore. This guides the measures aimed to reduce deformation of waterproof stratum (e. g. backfilling). Microseismic activity depends on parameters of miming, as well as physical and mechanical properties of the productive layers. The highest level of microseismic activity is observed in the areas where three ore layers are mined out. The Vk layer composed of the most brittle and weak ore rock - camallite - shows higher seismicity as compared to the other layers. The dry backfill has a greater effect to the reduction of radiated seismic energy than the hydraulic backfill. The seismic activity does not spatially correlate with the current mining operations. The seismicity generally appears several years after the mining. The time lag between mining and seismic activity varies for different mines and working layers. On average it is 15-20 years.