In the frames of examination of hepato-biopsies samples, taken from patients with chronic hepatitis, there was conducted analysis of essential anatomic criteria of HCV infection. There was also detected its interaction with signs of histological activity and liver fibrosis. In the course of chronic active hepatitis C, there was identified unfavorable prognostic value of hepatic steatosis in biopsy samples, mobilization of sinusoidal cells, signs of lymphocyte hyperplasia, correlating with high histological activity, severe fibrosis and cirrhosis.