Interaction of the lithosphere and the biosphere with a view of socioeconomic activity by a human being has the most complete effect in the process of mineral resource utilization. It is typical of mining and metal production complexes (MMC) of the Ural, which are basic for the regional economy. A research methodology related to anthropogenic transformation of environment caused by MMCs, including techniques, principles of construction, forms, means and approaches to the scientific knowledge has been developed.